Activity: Talk or presentation types › Invited talk
Background: With the increasing density of SNP markers, attention is rapidly shifting from traditional linkage and positional cloning methods for gene discovery to association methods for complex diseases. Due to the fact that complex traits presumably arise from multiple interacting genes located throughout the genome, it would be appropriate to search for sets of marker loci in different genes and to analyze these markers jointly rather than testing each marker in isolation. Thus, identification of the causal mutation(s) can be difficult, as there are potentially a large number of polymorphic sites within a gene, many of which may appear to be associated with a disease simply because they are in linkage disequilibrium with a causal mutation but have no functional significance on their own. Interest in SNPs and SNP-based association analyses are not likely to diminish soon. However, if progress in SNP-based initiatives is to be made, it is important to recognize and document the potential strengths and weaknesses of analysis methods making use of SNP applications.
27 Apr 2017 → 29 Apr 2017
Third ISPAD/ASPED/Lilly Diabetes Postgraduate Course: ISPAD