Motasem Melhem, BSc

Senior Research Assistant

  • P.O Box 1180, Dasman

    Kuwait

  • 143 Citations
  • 6 h-Index
20112020

Research output per year

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Research Output

2020

Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population

Hebbar, P., Abu-Farha, M., Alkayal, F., Nizam, R., Elkum, N., Melhem, M., John, S. E., Channanath, A., Abubaker, J., Bennakhi, A., Al-Ozairi, E., Tuomilehto, J., Pitkaniemi, J., Alsmadi, O., Al-Mulla, F. & Thanaraj, T. A., 13 Jan 2020, In : Scientific Reports. 10, 1, p. 152 152.

Research output: Contribution to journalArticle

Open Access

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

Al-Rashed, F., Ahmad, Z., Thomas, R., Melhem, M., Snider, A., Obeid, L., Al-Mulla, F., Hannun, Y. & Ahmad, R., 2020, In : BioRxiv.

Research output: Contribution to journalArticle

Corrigendum: Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children: Caveolin-1 variant is associated with the metabolic syndrome in Kuwaiti children (Frontiers in Genetics ( 2018) 9 (689) DOI: 10.3389/fgene.2018.00689)

Nizam, R., Al-Ozairi, E., Goodson, J. M., Melhem, M., Davidsson, L., Alkhandari, H., Al Madhoun, A., Shamsah, S., Qaddoumi, M., Alghanim, G., Alhasawi, N., Abu-Farha, M., Abubaker, J., Shi, P., Hartman, M-L., Tavares, M., Bitar, M., Ali, H., Arefanian, H., Devarajan, S. & 4 others, Al-Refaei, F., Alsmadi, O., Tuomilehto, J. & Al-Mulla, F., 1 Jan 2019, In : Frontiers in Genetics. 10, MAR, p. 221 1 p., 221.

Research output: Contribution to journalComment/debate

Open Access
2 Citations (Scopus)

Mitochondrial DNA D-loop sequencing reveals obesity variants in an Arab population

Eaaswarkhanth, M., Melhem, M., Sharma, P., Nizam, R., Al Madhoun, A., Chaubey, G., Alsmadi, O. & Al-Mulla, F., 24 May 2019, In : Application of Clinical Genetics. 2019, 12, p. 63 70 p.

Research output: Contribution to journalArticle

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6 Downloads (Pure)

Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population

Hebbar, P., Nizam, R., Melhem, M., Alkayal, F., Elkum, N., John, S. E., Tuomilehto, J., Alsmadi, O. & Thanaraj, A. T., 1 Jan 2018, In : Journal of Lipid Research. 59, 10, p. 1951-1966 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals

Mezzavilla, M., Tomei, S., Alkayal, F., Melhem, M., Mahmoud Kamkar, M., Al-Arouj, M., Bennakhi, A., Alsmadi, O. & Elkum, N., 30 Jan 2018, In : Journal of Translational Medicine. 16, 1, 20.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2017

Exome sequencing for the differential diagnosis of ciliary chondrodysplasias: Example of a WDR35 mutation case and review of the literature

Antony, D., Nampoory, N., Bacchelli, C., Melhem, M., Wu, K., James, C. T., Beales, P. L., Hubank, M., Thomas, D., Mashankar, A., Behbehani, K., Schmidts, M. & Alsmadi, O., 1 Dec 2017, In : European Journal of Medical Genetics. 60, 12, p. 658-666 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia

Melhem, M., Abu-Farha, M., Antony, D., Al Madhoun, A., Bacchelli, C., Alkayal, F., Al khairi, I., John, S. E., Alomari, M., Beales, P. L. & Alsmadi, O., 1 Mar 2017, In : European Journal of Haematology. 98, 3, p. 218-227 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesity-related traits and mediates by interacting with Apo-A1

Hebbar, P., Alkayal, F., Nizam, R., Melhem, M., Elkum, N., John, S. E., Abu-Farha, M., Alsmadi, O. & Thanaraj, A. T., 1 Jun 2017, In : Obesity. 25, 6, p. 1098-1108 11 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2016

ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits

Abu-Farha, M., Melhem, M., Abubaker, J., Behbehani, K., Alsmadi, O. & Elkum, N., 11 Feb 2016, In : Lipids in Health and Disease. 15, 1, 195.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

GWA Study from Kuwait Highlights Junk DNA as a Potential Hotspot in Hypertension Research: 9th World Congress on Prevention of Diabetes and its Complications

Nizam, R., Hebbar, P., Antony, DI., Alkayal, F., John, S. E., Thomas, D., Melhem, M., Tuomilehto, J., Thanaraj, A. T. & Alsmadi, O., Dec 2016, WCPD9 Abstracts. Suppl 6) 27 ed. Endocrine Practice, Vol. 22.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hereditary angioedema in a Jordanian family with a novel missense mutation in the C1-inhibitor N-terminal domain

Jaradat, S. A., Caccia, S., Rawashdeh, R., Melhem, M., Al-Hawamdeh, A., Carzaniga, T. & Haddad, H., 1 Mar 2016, In : Molecular Immunology. 71, p. 123-130 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Unraveling Kuwait-specific metabolic gene regulatory and coding variants: a step towards building a national exome database

Nizam, R., Antony, DI., John, S. E., Hebbar, P., Melhem, M., Tuomilehto, J., Thanaraj, A. T. & Alsmadi, O., Dec 2016, WCPD9 Abstracts. Endocr Pract, Vol. 22 (suppl 6). p. 1-29

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2014

Leptin in association with common variants of MC3R mediates hypertension

Alsmadi, O., Melhem, M., Hebbar, P., Thareja, G., John, S. E., Alkayal, F., Behbehani, K. & Thanaraj, A. T., 1 Jan 2014, In : American Journal of Hypertension. 27, 7, p. 973-981 9 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

ND4L gene concurrent 10609T>C and 10663T>C mutations are associated with Leber's hereditary optic neuropathy in a large pedigree from Kuwait

Behbehani, R., Melhem, M., Alghanim, G., Behbehani, K. & Alsmadi, O., 1 Jan 2014, In : British Journal of Ophthalmology. 98, 6, p. 826-831 6 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Response to leptin and nitric oxide in blood pressure regulation in humans

Alsmadi, O., Melhem, M., Hebbar, P., Channanath, A., Thareja, G., John, S. E., Alkayal, F., Behbehani, K. & Thanaraj, A. T., 27 Jul 2014, In : American Journal of Hypertension. 27, 11, p. 1429-1430 2 p.

Research output: Contribution to journalLetter

Open Access
3 Citations (Scopus)

Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes

Elkum, N., Alkayal, F., Noronha, F., Mahmoud Kamkar, M., Melhem, M., Al-Arouj, M., Bennakhi, A., Behbehani, K., Alsmadi, O. & Abubaker, J., 18 Nov 2014, In : PloS one. 9, 11, e113102.

Research output: Contribution to journalArticle

Open Access
44 Citations (Scopus)
2013

Interaction of Osteopontin with IL-18 in Obese Individuals: Implications for Insulin Resistance

Ahmad, R., Al-Mass, A., Al-Ghawas, D., Alam-Eldin, N., Zghoul, N., Melhem, M., Hasan, A., Al-Ghimlas, F., Dermime, S. & Behbehani, K., 13 May 2013, In : PloS one. 8, 5, e63944.

Research output: Contribution to journalArticle

Open Access
30 Citations (Scopus)

Major histocompatibility complex class II deficiency in Kuwait: Clinical manifestations, immunological findings and molecular profile

Al-Herz, W., Alsmadi, O., Melhem, M., Recher, M., Frugoni, F. & Notarangelo, L. D., 1 Apr 2013, In : Journal of Clinical Immunology. 33, 3, p. 513-519 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2011

Genetic Association Studies in Arab Populations: Status and Future Insight

Mahmoud Kamkar, M., Alsmadi, O., Thanaraj, A. T., Melhem, M. & Alkayal, F., 14 Mar 2011.

Research output: Contribution to conferencePoster