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2020

Identification of HLA‐C*16:46 allele in a Kuwaiti individual

Jacob, S., 1 Jan 2020, In : HLA. 95, 1, p. 71-72 2 p.

Research output: Contribution to journal › Article

2019

1871-P: Mir 103/107 Regulates Lipid Metabolism by Inhibiting Betatrophin/ANGPTL8

ABU-FARHA, MOHAMED., CHERIAN, PREETHI. THOMAS., AL KHAIRI, IRINA., AL-MULLA, FAHD. & ABUBAKER, JEHAD., 2019, American Diabetes Association Inc.

Research output: Other contribution

268-LB: Investigating the Role of MPO and ANGPTL6 in Obesity and Diabetes and Their Potential Role in Wound Healing

QADDOUMI, MOHAMMAD. G., ABU-FARHA, MOHAMED., CHERIAN, PREETHI. THOMAS., AL KHAIRI, IRINA., CHANNANATH, ARSHAD. MOHAMED., ALANBAEI, MUATH., ABUBAKER, JEHAD. & AL-MULLA, FAHD., 2019, American Diabetes Association Inc.

Research output: Other contribution

312-LB: Irisin, Meteorin-Like Protein, and Bone Remodeling Markers in T2D and Obesity

ABU-FARHA, MOHAMED., CHERIAN, PREETHI. THOMAS., AL KHAIRI, IRINA., JAMAL, MOHAMMAD., AL-SABAH, SULEIMAN., Ali, H., DSOUZA, CAROL., ALOTAIBI, FATEMAH. KULAIB., AL-ALI, WALEED. & AL-KHALEDI, GHANIM. MOHAMMAD., 2019, American Diabetes Association Inc.

Research output: Other contribution

A420 The Effect of Sleeve Gastrectomy on The Uncoupling Proteins in Animal Rat Model

Jamal, M., Abu-Farha, M., Al-Khaledi, G., Al-Sabah, S., Ali, H., Al-Otaibi, F., Dsouza, C., Al-Ali, W. & Al-Mulla, F., 2019, In : Surgery for Obesity and Related Diseases. 15, 10, p. S171

Research output: Contribution to journal › Article

Acsl1 regulates tnfα-induced gm-csf production by breast cancer mda-mb-231 cells

Ahmad, R., Thomas, R., Al-Rashed, F., Akhter, N. & Al-Mulla, F., Oct 2019, In : Biomolecules. 9, 10, 555.

Research output: Contribution to journal › Article

Open Access
Granulocyte-Macrophage Colony-Stimulating Factor
Breast Neoplasms
Tumor Necrosis Factor-alpha
Phosphorylation
p38 Mitogen-Activated Protein Kinases
5 Citations (Scopus)

Acute effects of air pollution on mortality: A 17-year analysis in Kuwait

Achilleos, S., Al Ozairi, E., Alahmad, B., Garshick, E., Neophytou, A. M., Bouhamra, W., Yassin, M. F. & Koutrakis, P., 1 May 2019, In : Environment International. 126, p. 476-483 8 p.

Research output: Contribution to journal › Article

Open Access
visibility
atmospheric pollution
air quality
mortality
dust storm
2 Citations (Scopus)

Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance

Kchumon, S., Salem Alrashed, F., Abu-Farha, M., Sriraman, D., Tuomilehto, J. & Ahmad, R., 1 Feb 2019, In : Diabetes/Metabolism Research and Reviews. 35, 2, p. e3087 e3087.

Research output: Contribution to journal › Article

Open Access
Chemokine CCL19
Insulin Resistance
Adipose Tissue
Adiponectin
Interleukin-12

Angiopoietin-like proteins in multiple sclerosis

Al-Temaimi, R., Cherian, P., Abu-Farha, M. & Alroughani, R., 15 May 2019, In : Journal of Neuroimmunology. 330, p. 31-34 4 p.

Research output: Contribution to journal › Article

Angiopoietins
Multiple Sclerosis
Proteins
Therapeutics
Lipid Metabolism

ANGPTL4 a predictive marker for diabetic nephropathy.

Alshawaf, E., Abu-Farha, M., Sriraman, D., ALSAIRAFI, ZAHRA., Al Khairi, I., Cherian, P., Mohamed Ali Yaseen, H., Mathur, A., Al-Mulla, F., AlAttar, A. & Abubaker, J., 1 Jan 2019, In : Journal of Diabetes Research. 2019, p. 4943191 4943191.

Research output: Contribution to journal › Article

Open Access
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Creatinine
Fasting
Biomarkers
4 Citations (Scopus)

A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations

Hebbar, P., Abubaker, J. A., Abu-Farha, M., Tuomilehto, J., Al-Mulla, F. & Thanaraj, A. T., 1 Jan 2019, In : Frontiers in Endocrinology. 10, JAN, p. 8 1 p.

Research output: Contribution to journal › Article

Association between Adipose Tissue Interleukin-33 and Immunometabolic Markers in Individuals with Varying Degrees of Glycemia

Hasan, A., Kochumon, S., Al Ozairi, E., Tuomilehto, J. & Ahmad, R., Apr 2019, In : Disease Markers. 2019, 7901062, p. 7901062 7901062.

Research output: Contribution to journal › Article

Open Access
Adipose Tissue
Tissue
Medical problems
Type 2 Diabetes Mellitus
Prediabetic State

Audit of glycemic control in patients with type 1 diabetes referred to a pediatric clinic in a specialized center in Kuwait,

Mahmoud Yousef Alabdulrazzaq, D., Al-Taiar, A., Shaltout, A., Davidsson, L. & Mohammad Abdullah Al-kandari, H., 1 Oct 2019, In : Diabetes Research and Clinical Practice. 156, 107827.

Research output: Contribution to journal › Article

Kuwait
Type 1 Diabetes Mellitus
Pediatrics
Subcutaneous Infusions
Hemoglobins

Bariatric surgery modulates urinary levels of MicroRNAs involved in the regulation of renal function

Alkandari, A., Ashrafian, H., Sathyapalan, T., Darzi, A., Holmes, E., Athanasiou, T., Atkin, S. L. & Gooderham, N. J., 1 Jan 2019, In : Frontiers in Endocrinology. 10, MAY, p. 319 319.

Research output: Contribution to journal › Article

Open Access
Bariatric Surgery
MicroRNAs
Kidney
Urine
Transfection

Can structured education for women with gestational diabetes enhance knowledge and self-confidence in managing diabetes? A tertiary centre experience report.

Gray, T., Prince, L., Venkarataman, H., Mahadasu, S., Meneni, D. & Aldibbiat, A. M., Mar 2019.

Research output: Contribution to conference › Poster

Can weekly ‘foot alerts’ using a bespoke mobile app improve patient diabetic foot care knowledge and practices in Kuwait?

Aldibbiat, A. M., Messenger, G., Al Ozairi, E., Hussain, I., Masoetsa, R. & Assi, M., 2019.

Research output: Contribution to conference › Abstract

Mobile Applications
Kuwait
Diabetic Foot
Foot
Podiatry

Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children (vol 9, 689, 2018)

Nizam, R., Al-Ozairi, E., Goodson, J. M., Melhem, M., Davidsson, L., Alkhandari, H., Al Madhoun, A., Shamsah, S., Qaddoumi, M. & Alghanim, G., 2019, In : Frontiers in Genetics. 10

Research output: Contribution to journal › Article

Corrigendum: Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children: Caveolin-1 variant is associated with the metabolic syndrome in Kuwaiti children (Frontiers in Genetics ( 2018) 9 (689) DOI: 10.3389/fgene.2018.00689)

Nizam, R., Al-Ozairi, E., Goodson, J. M., Melhem, M., Davidsson, L., Alkhandari, H., Al Madhoun, A., Shamsah, S., Qaddoumi, M., Alghanim, G., Alhasawi, N., Abu-Farha, M., Abubaker, J., Shi, P., Hartman, M-L., Tavares, M., Bitar, M., Ali, H., Arefanian, H., Devarajan, S. & 4 others, Al-Refaei, F., Alsmadi, O., Tuomilehto, J. & Al-Mulla, F., 1 Jan 2019, In : Frontiers in Genetics. 10, MAR, p. 221 1 p., 221.

Research output: Contribution to journal › Comment/debate

Caveolin 1
Manuscripts
Names
Genes
corrigendum

Dasman Diabetes Biobank Kuwait – Operations Overview

Sriraman, D., Lopez, V., Mathur, A., Chandy, B. S., Shyamsundar, A., Jose, R. M., Vijayan, V., Abu-Farha, M. & Al-Mulla, F., 2019.

Research output: Contribution to conference › Poster

1 Citation (Scopus)

Diabetes impairs angiogenesis and induces endothelial cell senescence by up-regulating thrombospondin-CD47-dependent signaling

Sami Bitar, M., 4 Feb 2019, In : International Journal of Molecular Sciences. 20, 3, 673.

Research output: Contribution to journal › Article

Open Access
Thrombospondins
angiogenesis
Cell Aging
Endothelial cells
Medical problems

Dynamic oligomerization of hRAGE's transmembrane and cytoplasmic domains within SDS micelles

Zamoon, J., Madhu, D. & Ahmed, I., 1 Jun 2019, In : International Journal of Biological Macromolecules. 130, p. 10-18 9 p.

Research output: Contribution to journal › Article

Oligomerization
Micelles
Detergents
Oligomers
Escherichia coli
1 Citation (Scopus)

Early immune mechanisms of neonatal porcine islet xenograft rejection

Mok, D., Black, M., Arefanian, H., Tredget, E. & Rayat, G. R., 1 Nov 2019, In : Xenotransplantation. 26, 6, e12546.

Research output: Contribution to journal › Article

Heterografts
Swine
Transplants
Heterologous Transplantation
Autoimmunity

Experiences of people with type 1 diabetes fasting Ramadan following structured education: A qualitative study

Alsaeed, D., Al Kandari, J. & Al Ozairi, E., Jul 2019, In : Diabetes Research and Clinical Practice. 153, p. 157-165 9 p.

Research output: Contribution to journal › Article

Open Access
Type 1 Diabetes Mellitus
Fasting
Education
Eating
Interviews

Genomic Revolution-Driven Cancer Research

Meganathan, R. P. & Eaaswarkhanth, M., 2019, Essentials of Bioinformatics, Volume II: In Silico Life Sciences: Medicine. Shaik, N. A., Hakeem, K. R., Banaganapalli, B. & Elango, R. (eds.). 1 ed. Vol. II. p. 39 60 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Glucose-Mediated Glucose Disposal at Baseline Insulin Is Impaired in IFG

Alatrach, M., Agyin, C., Mehta, R., Adams, J., DeFronzo, R. A. & Abdulghani, M., 1 Jan 2019, In : The Journal of clinical endocrinology and metabolism. 104, 1, p. 163-171 9 p.

Research output: Contribution to journal › Article

Fasting
Insulin
Glucose
Clamping devices
Glucose Clamp Technique

Glycemic control in Kuwaiti diabetes patients treated with glucose-lowering medication

Abdullah, A., Alkandari, A., Longenecker, J. C., Sriraman, D., Alkhatib, A., AlWotayan, R., Al Duwairi, Q. & Tuomilehto, J., 2019, In : Primary Care Diabetes. 6 p., https://doi.org/10.1016/j.pcd.2019.12.001.

Research output: Contribution to journal › Working Manuscript - presubmission to Journal

Kuwait
Fasting
Glucose
Guidelines
National Institutes of Health (U.S.)
1 Citation (Scopus)

Higher Levels of ANGPTL5 in the Circulation of Subjects With Obesity and Type 2 Diabetes Are Associated With Insulin Resistance

Alghanim, G., Qaddoumi, M. G., Alhasawi, N., Cherian, P., Al-Khairi, I., Nizam, R., Alkayal, F., Alanbaei, M., Tuomilehto, J., Abubaker, J., Abu-Farha, M. & Al-Mulla, F., 1 Jan 2019, In : Frontiers in Endocrinology. 10, p. 495 1 p., 495.

Research output: Contribution to journal › Article

Type 2 Diabetes Mellitus
Insulin Resistance
Obesity
Triglycerides
Angiopoietins

How can we support people with Type 1 diabetes during Ramadan? Insight following a structured education workshop and telemonitoring service in Kuwait

Alsaeed, D., Al Kandari, J., Taghadom, E., El Samad, A., Murad, S., Megahed, A., Al Ibrahim, S. & Al Ozairi, E., 2019.

Research output: Contribution to conference › Abstract

Incidence of type 2 diabetes in Kuwaiti children and adolescents: Results from the Childhood-Onset Diabetes electronic Registry (CODeR

Mohammad Abdullah Al-kandari, H., Mahmoud Yousef Alabdulrazzaq, D., Davidsson, L., Sharma, P., Al-Tararwa, A., Mandani, F., Al-Shawaf, F., Al-Hussaini, F., Qabazard, M., Haddad, D., Al-Mahdi, M., Al-Jasser, F., Al-Anzi, A., Al-Sanea, H., Al-Basari, I., Al-Adsani, A., Shaltout, A. & AbdulRasoul, M., 2019, In : Frontiers in Endocrinology. 10, 836

Research output: Contribution to journal › Article

Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation

Sindhu, S., Thomas, R., Kochumon, S., Wilson, A., Abu-Farha, M., Bennakhi, A., Al-Mulla, F. & Ahmad, R., 11 Nov 2019, In : cells. 8, 11

Research output: Contribution to journal › Article

Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin.

Al Khairi, I., Cherian, P., Abu-Farha, M., Al Madhoun, A., Nizam, R., Melhem, M., Jamal, M. H., Al-Sabah, S., Mohamed Ali Yaseen, H., Tuomilehto, J., Al-Mulla, F. & Abubaker, J., Oct 2019, In : cells. 8, 10

Research output: Contribution to journal › Article

Intermittent Fasting Could Be Safely Achieved in People With Type 1 Diabetes Undergoing Structured Education and Advanced Glucose Monitoring

Aldibbiat, A. M., El-Samad, A., Al Kandari, J. & Al Ozairi, E., 5 Dec 2019, In : Frontiers in Endocrinology. 10, p. 1 9 p., 849.

Research output: Contribution to journal › Article

Open Access
Type 1 Diabetes Mellitus
Fasting
Hypoglycemia
Education
Glucose

Irisin, Meteorin-like protein and Bone remodeling markers in Obesity and T2D

Cherian, P., Al Khairi, I., Abubaker, J., Abu-Farha, M., Mohamed, G., Mohamed Ali Yaseen, H., DSOUZA, CAROL., Al-Otaibi, F., Al-Ali, W., AL-KHALEDI, GHANIM. MOHAMMAD. & Al-Mulla, F., 9 Jun 2019.

Research output: Contribution to conference › Poster

Bone Remodeling
Type 2 Diabetes Mellitus
Obesity
Proteins
Bone and Bones

Is There a Role for Informal Caregivers in the Management of Diabetic Foot Ulcers? A Narrative Review

Messenger, G., Taha, N., Sabau, S., AlHubail, A. & Aldibbiat, A. M., 1 Dec 2019, In : Diabetes Therapy. 10, 6, p. 2025-2033 9 p.

Research output: Contribution to journal › Review article

Open Access
Diabetic Foot
Caregivers
Amputation
Delivery of Health Care
Patient Participation
3 Citations (Scopus)

James Lind Alliance research priorities: what role do carbohydrates, fats and proteins have in the management of Type 2 diabetes, and are there risks and benefits associated with particular approaches?

Dyson, P., McArdle, P., Mellor, D. & Guess, N., 1 Mar 2019, In : Diabetic Medicine. 36, 3, p. 287-296 10 p.

Research output: Contribution to journal › Review article

Type 2 Diabetes Mellitus
Fats
Carbohydrates
Research
Food
2 Citations (Scopus)

Ketogenic diet attenuates cerebellar atrophy progression in a subject with a biallelic variant at the ATAD3A locus.

Al Madhoun, A., F, A., Melhem, M., Nizam, R., T, AL-D. & Al-Mulla, F., 1 Jan 2019, In : Application of Clinical Genetics. 12, p. 79-86 8 p.

Research output: Contribution to journal › Article

Open Access
Ketogenic Diet
Atrophy
Mitochondrial Dynamics
Exome
Mutation

Ketogenic diet attenuates cerebellar atrophy progression in a subject with a biallelic variant at the ATAD3A locus [Response to Letter].

Al Madhoun, A., F, A., Melhem, M., Nizam, R., T, AL-D. & Al-Mulla, F., 1 Jan 2019, In : Application of Clinical Genetics. 12, p. 163-165 3 p.

Research output: Contribution to journal › Article

Open Access

Leptin rs7799039 polymorphism is associated with multiple sclerosis risk in Kuwait

Jacob, S., Nov 2019, In : Multiple Sclerosis and Related Disorders. 36, 101409.

Research output: Contribution to journal › Article

Method for preventing cardio-metabolic disease

Hasan, A. & Al-Dhahi, W., 2019, (Submitted)

Research output: Patent

Method for preventing progression to type II diabetes

Hasan, A., 2019, (Submitted)

Research output: Patent

2 Citations (Scopus)

MIP-1α Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism

Ahmad, R., Akhter, N., Abu-AlRoub, A., Kchumon, S., Wilson, A., Thomas, R., Ali, S., Tuomilehto, J. & Sindhu, S., 1 Jan 2019, In : Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 52, 2, p. 212-224 13 p.

Research output: Contribution to journal › Article

Open Access
Macrophage Inflammatory Proteins
Palmitates
NF-kappa B
Transcription Factor AP-1
Nonesterified Fatty Acids
1 Downloads (Pure)

Mitochondrial DNA D-loop sequencing reveals obesity variants in an Arab population

Eaaswarkhanth, M., Melhem, M., Sharma, P., Nizam, R., Al Madhoun, A., Chaubey, G., Alsmadi, O. & Al-Mulla, F., 24 May 2019, In : Application of Clinical Genetics. 2019, 12, p. 63 70 p.

Research output: Contribution to journal › Article

File
Kuwait
Mitochondrial DNA
Obesity
Population
Haplotypes

NFAT5 is directly correlated with IL-33 and ST2 in the adipose tissue of individuals with normal glycemia but not prediabetes

Hasan, A., Kochumon, S., Al Ozairi, E., Al-Mulla, F. & Ahmad, R., 2019.

Research output: Contribution to conference › Poster

4 Citations (Scopus)

Oxidative stress induces expression of the toll-like receptors (TLRs) 2 and 4 in the human peripheral blood mononuclear cells: Implications for metabolic inflammation

Akhter, N., Madhoun, A., Arefanian, H., Wilson, A., Kochumon, S., Thomas, R., Shenouda, S., Al-Mulla, F., Ahmad, R. & Sindhu, S., 1 Jan 2019, In : Cellular Physiology and Biochemistry. 53, 1, p. 1-18 18 p.

Research output: Contribution to journal › Article

Open Access
Toll-Like Receptor 2
Toll-Like Receptor 4
Blood Cells
Oxidative Stress
Inflammation
4 Citations (Scopus)

Oxidative Stress Induces Expression of the Toll-Like Receptors (TLRs) 2 and 4 in the Human Peripheral Blood Mononuclear Cells: Implications for Metabolic Inflammation.

Akhter, N., Al Madhoun, A., Arefanian, H., Wilson, A., Kochumon, S., Thomas, R., Shenouda, S., Al-Mulla, F., Ahmad, R. & Sindhu, S., 2019, In : Cellular Physiology and Biochemistry. 53, 1, p. 1-18 18 p.

Research output: Contribution to journal › Article

Toll-Like Receptor 2
Toll-Like Receptor 4
Blood Cells
Oxidative Stress
Inflammation

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Marafie, S., 10 Oct 2019.

Research output: Contribution to conference › Poster

1 Citation (Scopus)

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Marafie, S. K., AlShawaf, E., Abubaker, J. & Arefanian, H., 19 Aug 2019, In : Biological Research. 52, 1, p. 44 1 p.

Research output: Contribution to journal › Article

Palmitic Acid
Nonesterified Fatty Acids
palmitic acid
free fatty acids
receptors

Photo-Assisted Dietary Method Improves Estimates of Dietary Intake Among People with Sleeve Gastrectomy

Al Ozairi, E., AlAwadhi, M. M., Al Kandari, J., Taghadom, E., Abdullah, M. & Le Roux, C. W., 15 May 2019, In : Obesity Surgery. 29, 5, p. 1602-1606 5 p.

Research output: Contribution to journal › Article

Gastrectomy
Eating
Telemedicine
Weights and Measures
Carbohydrates
3 Citations (Scopus)

Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes

DeFronzo, R. A., Inzucchi, S., Abdulghani, M. & Nissen, S. E., 1 Mar 2019, In : Diabetes and Vascular Disease Research. 16, 2, p. 133-143 11 p.

Research output: Contribution to journal › Article

pioglitazone
Type 2 Diabetes Mellitus
Myocardial Infarction
Costs and Cost Analysis
Drug Costs

Pioglitazone prevents the increase in plasma ketone concentration associated with dapagliflozin in insulin-treated T2DM patients: Results from the Qatar Study

Abdulghani, M., Migahid, O., Megahed, A., Singh, R., Fawaz, M., DeFronzo, R. A. & Jayyousi, A., 1 Mar 2019, In : Diabetes, Obesity and Metabolism. 21, 3, p. 705-709 5 p.

Research output: Contribution to journal › Article

pioglitazone
Qatar
Ketones
Insulin
Hypoglycemia