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• 2020

  A comprehensive germline variant and expression analyses of ACE2, TMPRSS2 and SARS-CoV-2 activator FURIN genes from the Middle East: Combating SARS-CoV-2 with precision medicine

  Al-Mulla, F., Mohammad, A., Al Madhoun, A., Haddad, D., Ali, H., Eaaswarkhanth, M., John, S. E., Nizam, R., Channanath, A., Abu-Farha, M., Ahmad, R., Abubaker, J. & Thanaraj, A. T., 16 May 2020, In : BioRxiv. BIORXIV/2020/099176, p. 1 to 28 28 p.

  Research output: Contribution to journal › Article

  Open Access

  • SARS Virus
  • Middle East
  • Precision Medicine
  • Peptide Hydrolases
  • Genes

• Adaptive fitness advantage in ancestors: a major health risk to a present-day Arab population

  Eaaswarkhanth, M., Campelo dos Santos, A. L., Gokcumen, O., Al-Mulla, F. & Thanaraj, A. T., 20 Apr 2020.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

• Adipose tissue gene expression of CXCL10 and CXCL11 modulates inflammatory markers in obesity: implications for metabolic inflammation and insulin resistance

  Kochumon, S., Madhoun, A. A., Al-Rashed, F., Azim, R., Al-Ozairi, E., Al-Mulla, F. & Ahmad, R., 2020, In : Therapeutic Advances in Endocrinology and Metabolism. 11, p. 2042018820930902

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adipose Tissue
  • Insulin Resistance
  • Obesity
  • Gene Expression
  • Inflammation

• Adopting identification standards in the medical device supply chain

  Abdulsalam, Y., Alhuwail, D. & Schneller, E. S., 1 Jan 2020, In : International Journal of Information Systems and Supply Chain Management. 13, 1, p. 1-14 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Medical Devices
  • Biomedical equipment
  • Supply chains
  • Supply Chain
  • Product Safety

• Adult Diabetes and Prediabetes Prevalence in Kuwait: Data from the Cross-Sectional Kuwait Diabetes Epidemiology Program

  Alkandari, A., Alarouj, M., Elkum, N., Sharma, P., Sriraman, D., Abu-Farha, M., Al-Mulla, F., Tuomilehto, J. & Bennakhi, A., 2020, In : Journal of Clinical Medicine. 9:3420, doi:10.3390/jcm9113420

  Research output: Contribution to journal › Article › peer-review

  • Kuwait
  • Prediabetic State
  • Epidemiology
  • Glucose
  • Fasting

• Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy

  Al Shawaf, E., Al-Ozairi, E., Al-Asfar, F., Mohammad, A., Al-Beloushi, S., Devarajan, S., Al-Mulla, F., Abubaker, J. & Arefanian, H., 2020, In : Journal of Diabetes Research. 2020, doi.org/10.1155/2020/2091341, p. 2091341 2091341.

  Research output: Contribution to journal › Article › peer-review

  • Gastrectomy
  • Morbid Obesity
  • Cardiovascular Diseases
  • Type 2 Diabetes Mellitus
  • Bariatric Surgery

• Combination therapy with pioglitazone/exenatide improves beta-cell function and produces superior glycaemic control compared with basal/bolus insulin in poorly controlled type 2 diabetes: A 3-year follow-up of the Qatar study

  Abdul-Ghani, M., Migahid, O., Megahed, A., DeFronzo, R. A., Al-Ozairi, E. & Jayyousiv, A., 2020, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

  Research output: Contribution to journal › Article › peer-review

• Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells

  Al Madhoun, A., Marafie, S. K., Haddad, D., Melhem, M., Abu-Farha, M., Ali, H., Sindhu, S., Atari, M. & Al-Mulla, F., 3 Sep 2020, In : International Journal of Molecular Sciences. 21, 17

  Research output: Contribution to journal › Article › peer-review

  • Wharton Jelly
  • Stem cells
  • stem cells
  • Proteomics
  • markers

• Continuous Glucose Monitoring of Glycemic Variability During Fasting Post-Sleeve Gastrectomy

  Al-Ozairi, E., El Samad, A., Al Kandari, J., Taghadom, E., Adam, S., le Roux, C. & Syed, A. A., 1 Oct 2020, In : Obesity Surgery. 30, 10, p. 3721-3729 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents

  Hammad, M. M., Abu-Farha, M., Al-Taiar, A., Alam-Eldin, N., Al-Sabah, R., Shaban, L., Al-Mulla, F., Abubaker, J. & Rahman, A., 14 Apr 2020, In : Scientific Reports. 10, 1, p. 6330 6330.

  Research output: Contribution to journal › Article › peer-review

  • oxidized low density lipoprotein
  • C-Reactive Protein
  • Obesity
  • Metabolic Diseases
  • Overweight

• Correlation profile of suppression of tumorigenicity 2 and/or interleukin-33 with biomarkers in the adipose tissue of individuals with different metabolic states

  Hasan, A., Kochumon, S., Al Ozairi, E., Tuomilehto, J., Al-Mulla, F. & Ahmad, R., 20 Oct 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.

  Research output: Contribution to journal › Article › peer-review

• Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?

  Eaaswarkhanth, M., Al Madhoun, A. & Al-Mulla, F., Jul 2020, In : International Journal of Infectious Diseases. 96, p. 459-460 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus
  • Mortality
  • Proteins
  • Mutation
  • Pandemics
  18 Citations (Scopus)

• Effect of sleeve gastrectomy on the expression of meteorin-like (METRNL) and Irisin (FNDC5) in muscle and brown adipose tissue and its impact on uncoupling proteins in diet-induced obesity rats

  Jamal, M. H., Abu-Farha, M., Al-Khaledi, G., Al-Sabah, S., Ali, H., Cherian, P., Al-Khairi, I., AlOtaibi, F., Al-Ali, W., Bosso, M., Dsouza, C., Abubaker, J. & Al-Mulla, F., 31 Jul 2020, In : Surgery for Obesity and Related Diseases.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Uncoupling Proteins
  • Brown Adipose Tissue
  • Gastrectomy
  • Obesity
  • Diet
  1 Citation (Scopus)

• Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance

  Kochumon, S., Al Madhoun, A., Al-Rashed, F., Thomas, R., Sindhu, S., Al-Ozairi, E., Al-Mulla, F. & Ahmad, R., 1 Dec 2020, In : Scientific Reports. 10, 1, 16364.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese Patients

  Sindhu, S., Kochumon, S., Thomas, R., Bennakhi, A., Al-Mulla, F. & Ahmad, R., 16 Mar 2020, In : Cells. 9, 3

  Research output: Contribution to journal › Article › peer-review

  • Interferon Regulatory Factors
  • Type 2 Diabetes Mellitus
  • Inflammation
  • Overweight
  • C-Reactive Protein

• Erratum: Protocol for a randomised controlled trial to investigate the effect of home- And gym-based resistance exercise training on glycaemic control, body composition and muscle strength (Trials (2020) 21: 557 DOI: 10.1186/s13063-020-04480-2)

  Al Ozairi, E., Alsaeed, D., Taliping, D., Jalali, M., El Samad, A., Mashankar, A., Taghadom, E., Guess, N., Gill, J. M. R., Sattar, N., Gray, C., Welsh, P. & Gray, S. R., 15 Jul 2020, In : Trials. 21, 1, 650.

  Research output: Contribution to journal › Comment/debate

  Open Access

• Evaluating the accessibility of higher education institution websites in the State of Kuwait: empirical evidence

  AlMeraj, Z., Boujarwah, F., Alhuwail, D. & Qadri, R., 2020, (Accepted/In press) In : Universal Access in the Information Society.

  Research output: Contribution to journal › Article › peer-review

  • Websites
  • Education
  • HTML
  • Landing
  • Managers

• Fasting Blood Glucose and COVID-19 Severity: Nonlinearity Matters

  Alahmad, B., Abdullah, A. S., Bennakhi, A., Al-Mulla, F. & Ali, H., Oct 2020, In : Diabetes Care. 43, 11

  Research output: Contribution to journal › Article › peer-review

• Fetuin-a expression profile in mouse and human adipose tissue

  Khadir, A., Kavalakatt, S., Madhu, D. & Tiss, A., 12 Mar 2020, In : Lipids in Health and Disease. 19, 1, 38.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Fetuins
  • alpha-2-HS-Glycoprotein
  • Tissue
  • Adipose Tissue
  • Intra-Abdominal Fat

• Fine-scale population structure reveals high genetic heterogeneity of the Kuwaiti population in the Arabian Peninsula

  Eaaswarkhanth, M., Pathak, A., Ongaro, L., Montinaro, F., Hebbar, P., Alsmadi, O., Metspalu, M., Al-Mulla, F. & Thanaraj, A. T., 23 Nov 2020, In : BioRxiv. BIORXIV/2020/393892, p. 1-18 18 p.

  Research output: Contribution to journal › Article

  Open Access

• Fructose tolerance test in obese people with and without type 2 diabetes

  Al-Ozairi, E., Rivard, C. J., Sanchez Lozada, L. G., Lanaspa, M. A., Bjornstad, P., Al Salem, D., Alhubail, A., Megahed, A., Kuwabara, M., Johnson, R. J. & Asad, R. A., 1 Mar 2020, In : Journal of Diabetes. 12, 3, p. 197-204 8 p.

  Research output: Contribution to journal › Article › peer-review

• FTO Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population

  Hebbar, P., Abu-Farha, M., Mohammad, A., Alkayal, F., Melhem, M., Abubaker, J., Al-Mulla, F. & Thanaraj, T. A., 31 Jan 2020, In : Frontiers in Genetics. 10, p. 1411 1411.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Body Water
  • Ghrelin
  • Apolipoproteins
  • Fats
  • Body Weight
  1 Citation (Scopus)

• Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population

  Hebbar, P., Abu-Farha, M., Alkayal, F., Nizam, R., Elkum, N., Melhem, M., John, S. E., Channanath, A., Abubaker, J., Bennakhi, A., Al-Ozairi, E., Tuomilehto, J., Pitkaniemi, J., Alsmadi, O., Al-Mulla, F. & Thanaraj, T. A., 13 Jan 2020, In : Scientific Reports. 10, 1, p. 152 152.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study
  • Fasting
  • Glucose
  • Genome
  • Population
  1 Citation (Scopus)

• Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population

  Hebbar, P., Abubaker, J. A., Abu-Farha, M., Alsmadi, O., Elkum, N., Alkayal, F., John, S. E., Channanath, A., Iqbal, R., Pitkaniemi, J., Tuomilehto, J., Sladek, R., Al-Mulla, F. & Thanaraj, T. A., 9 Sep 2020, In : Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  • Genome
  • Population
  • Genome-Wide Association Study
  • Inbreeding
  • Consanguinity

• Genome-wide Selection Scan in an Arabian Peninsula Population Identifies a TNKS haplotype Linked to Metabolic Traits and Hypertension.

  Eaaswarkhanth, M., Campelo dos Santos, A. L., Gokcumen, O., Al-Mulla, F. & Thanaraj, A. T., 17 Mar 2020, In : Genome Biology and Evolution. 12, 3, p. 77-87 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hypertension
  • genome
  • Haplotypes
  • haplotypes
  • Genome
  1 Citation (Scopus)

  1 Downloads (Pure)

• Higher BDNF Levels in the Circulation is Associated with Angiogenesis, Inflammatory and Metabolic Biomarkers in Children

  Hasan, A., Kochumon, S., Ali, S. & Mandani, F., 2020, (Accepted/In press).

  Research output: Contribution to conference › Poster › peer-review

• Higher binding affinity of Furin to SARS-CoV-2 spike (S) protein D614G could be associated with higher SARS-CoV-2 infectivity

  Mohammad, A., Alshawaf, E., Marafie, S. K., Abu-Farha, M., Abubaker, J. & Al-Mulla, F., 16 Oct 2020, In : International Journal of Infectious Diseases.

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus
  • Furin
  • Mutation
  • Protein Stability
  • Molecular Dynamics Simulation

• Identification and management of Lynch syndrome in the Middle East and North African countries: outcome of a survey in 12 countries

  2020, (Accepted/In press) In : Familial Cancer.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Identification of HLA‐C*16:46 allele in a Kuwaiti individual

  Jacob, S., 1 Jan 2020, In : HLA. 95, 1, p. 71-72 2 p.

  Research output: Contribution to journal › Article › peer-review

  • HLA-C Antigens
  • Alleles
  • Codon
  • Nucleotides

• Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

  23 Oct 2020, In : Science (New York, N.Y.). 370, 6515

  Research output: Contribution to journal › Article › peer-review

  Open Access
  18 Citations (Scopus)

• Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study

  Abdel-Halim, S. M., Al Madhoun, A., Nizam, R., Melhem, M., Cherian, P., Al-Khairi, I., Haddad, D., Abu-Farha, M., Abubaker, J., Bitar, M. S. & Al-Mulla, F., Sep 2020, In : Biology. 9, 9, p. 1-13 13 p., 244.

  Research output: Contribution to journal › Article › peer-review

  • noninsulin-dependent diabetes mellitus
  • cross-sectional studies
  • Medical problems
  • adenylate cyclase
  • obesity

• Increasing the Duration of Light Physical Activity Ameliorates Insulin Resistance Syndrome in Metabolically Healthy Obese Adults

  Al-Rashed, F., Alghaith, A., Azim, R., AlMekhled, D., Thomas, R., Sindhu, S. & Ahmad, R., 11 May 2020, In : Cells. 9, 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulin Resistance
  • Light
  • Exercise
  • Cytokines
  • Obesity

• Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes

  Qaddoumi, M. G., Alanbaei, M., Hammad, M. M., Al Khairi, I., Cherian, P., Channanath, A., Thanaraj, T. A., Al-Mulla, F., Abu-Farha, M. & Abubaker, J., 10 Apr 2020, In : Scientific Reports. 10, 1, p. 6170 6170.

  Research output: Contribution to journal › Article › peer-review

  • Angiopoietin-like Proteins
  • Peroxidase
  • Obesity
  • Type 2 Diabetes Mellitus
  • Biomarkers
  2 Citations (Scopus)

• Late bedtime and dental caries incidence in Kuwaiti children: A longitudinal multilevel analysis

  Alqaderi, H., Tavares, M., Al-Mulla, F., Al-Ozairi, E. & Goodson, J. M., 2020, (Accepted/In press) In : Community Dentistry and Oral Epidemiology.

  Research output: Contribution to journal › Article › peer-review

  • Multilevel Analysis
  • Dental Caries
  • Ghrelin
  • Leptin
  • Incidence
  1 Citation (Scopus)

• LPS induces GM-CSF production by breast cancer MDA-MB-231 cells via long-chain acyl-CoA synthetase 1

  Al-Rashed, F., Thomas, R., Al-Roub, A., Al-Mulla, F. & Ahmad, R., Oct 2020, In : Molecules. 25, 20, 4709.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Maturity-onset diabetes of the young (MODY): a time to act. a time to act

  Mohammad Abdullah Al-kandari, H., Mahmoud Yousef Alabdulrazzaq, D., Davidsson, L. & Al-Mulla, F., Jul 2020, In : The Lancet Diabetes and Endocrinology. 8, 7, p. 565-566 2 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort

  Hammad, M. M., Abu-Farha, M., Hebbar, P., Cherian, P., Al Khairi, I., Melhem, M., Alkayal, F., Alsmadi, O., Thanaraj, T. A., Al-Mulla, F. & Abubaker, J., Jul 2020, In : Frontiers in Endocrinology. 11, p. 437 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Melanocortin, Type 4
  • Nicotinamide Phosphoribosyltransferase
  • Ghrelin
  • Obesity
  • Hypertension
  1 Citation (Scopus)

• Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

  Alqaderi, D. H., Al Ozairi, E., Bin-Hasan, S., Tavares, M., Goodson, J. M., AlSumait, A., Abu-Farha, M., Abubaker, J., Sriraman, D., AlMuhana, N. & Al-Mulla, F., 5 Nov 2020, In : Biomarkers in Medicine. 12 p., ISSN 1752-0363.

  Research output: Contribution to journal › Article › peer-review

• Method For Preventing Progression To Metabolic Syndrome

  Al-Mulla, F., Nizam, R. & Al Madhoun, A., 4 Aug 2020, IPC No. US, Patent No. 10,731,219, B1, 19 Sep 2019

  Research output: Patent

  • Metabolic Syndrome
  • Caveolin 1
  • Pharmaceutical Preparations
  • Diet Therapy
  • Single Nucleotide Polymorphism

• MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

  Sindhu, S., Akhter, N., Wilson, A., Thomas, R., Arefanian, H., Al Madhoun, A., Al-Mulla, F. & Ahmad, R., 29 Jul 2020, In : Cells. 9, 8

  Research output: Contribution to journal › Article › peer-review

  • Macrophage Inflammatory Proteins
  • Palmitates
  • Oxidative Stress
  • Tumor Necrosis Factor-alpha
  • nuclear factor-jun

• Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

  Al-Rashed, F., Ahmad, Z., Thomas, R., Melhem, M., Snider, A., Obeid, L., Al-Mulla, F., Hannun, Y. & Ahmad, R., 1 Dec 2020, In : Scientific Reports. 10, 1, 16802.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sphingomyelin Phosphodiesterase
  • Monocytes
  • Macrophages
  • GW 4869
  • Ceramides

• Plasma Calprotectin Is Associated with Obesity and Systemic Inflammation in Children

  Hasan, A., Kochumon, S. & Mohammad Abdullah Al-kandari, H., Jun 2020.

  Research output: Contribution to conference › Poster › peer-review

• Positively selected TNKS haplotype: from evolutionary advantage to the health risk in an Arabian Peninsula population

  Eaaswarkhanth, M., Campelo dos Santos, A. L., Gokcumen, O., Al-Mulla, F. & Thanaraj, A. T., 6 Jun 2020.

  Research output: Contribution to conference › Poster › peer-review

  • haplotypes
  • hypertension
  • metabolic diseases
  • asthma
  • human population

• PR3 levels are impaired in plasma and PBMCs from Arabs with cardiovascular diseases

  Khadir, A., Madhu, D., Kavalakatt, S., Cherian, P., Alarouj, M., Bennakhi, A., Abubaker, J., Tiss, A. & Elkum, N., 2020, In : PloS one. 15, 1, e0227606.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloblastin
  • Arabs
  • mononuclear leukocytes
  • cardiovascular diseases
  • Blood

• Protocol for a randomised controlled trial to investigate the effect of home- And gym-based resistance exercise training on glycaemic control, body composition and muscle strength

  Al Ozairi, E., Alsaeed, D., Alsaeed, D., Taliping, D., Jalali, M., Jalali, M., El Samad, A., Mashankar, A., Taghadom, E., Taghadom, E., Guess, N., Gill, J. M. R., Sattar, N., Gray, C., Welsh, P. & Gray, S. R., 22 Jun 2020, In : Trials. 21, 1, 557.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Resistance Training
  • Muscle Strength
  • Body Composition
  • Randomized Controlled Trials
  • Exercise

• Rabson–Mendenhall Syndrome in a brother-sister pair in Kuwait: Diagnosis and 5 year follow up

  Al-Kandari, H., Al-Abdulrazzaq, D., Al-Jaser, F., Al-Mulla, F. & Davidsson, L., 2020, (Accepted/In press) In : Primary Care Diabetes.

  Research output: Contribution to journal › Article › peer-review

• Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway

  Al-Rashed, F., Sindhu, S., Arefanian, H., Al Madhoun, A., Kochumon, S., Thomas, R., Al-Kandari, S., Alghaith, A., Jacob, T., Al-Mulla, F. & Ahmad, R., 12 Aug 2020, In : Cells. 9, 8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hyperglycemia
  • Macrophages
  • Type 2 Diabetes Mellitus
  • Glucose
  • Interleukin-1
  1 Citation (Scopus)

• Repositioning of the global epicentre of non-optimal cholesterol

  Imperial College London, 4 Jun 2020, In : Nature. 582, 7810, p. 73-77 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • lipoprotein cholesterol
  • Southeastern Asia
  • Far East
  • Cholesterol
  • Income
  4 Citations (Scopus)

• RKIP & GSK3β: The interaction of two intracellular signaling network regulators and their role in cancer

  Bosso, M. & Al-Mulla, F., 5 Feb 2020, Prognostic and Therapeutic Applications of RKIP in Cancer. Elsevier, p. 147-173 27 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

• Role of Caveolin-1 in Diabetes and Its Complications

  Haddad, D., Al Madhoun, A., Nizam, R. & Al-Mulla, F., 28 Jan 2020, In : Oxidative Medicine and Cellular Longevity. 2020, p. 9761539 9761539 .

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Caveolin 1
  • Medical problems
  • Diabetes Complications
  • Signal transduction
  • Insulin
  4 Citations (Scopus)