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• 2021

  ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19

  Al-Mulla, F., Mohammad, A., Al Madhoun, A., Haddad, D., Ali, H., Eaaswarkhanth, M., John, S. E., Nizam, R., Channanath, A., Abu-Farha, M., Ahmad, R., Abubaker, J. & Thanaraj, T. A., Feb 2021, In: Heliyon. 7, 2, e06133.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals

  Alanbaei, M., Abu-Farha, M., Hebbar, P., Melhem, M., Chandy, B. S., Anoop, E., Cherian, P., Al-Khairi, I., Alkayal, F., Al-Mulla, F., Abubaker, J. & Thanaraj, T. A., 17 May 2021, In: Genes. 12, 5, 755.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Anthropometric cut-points for discriminating diabetes and metabolic syndrome among Arabs and Asians: The Kuwait Diabetes Epidemiology Program

  Oguoma, V. M., Coffee, N. T., Alsharrah, S., Abu-Farha, M., Al-Refaei, F. H., Alkandari, A., Al-Mulla, F. & Daniel, M., 2021, (Accepted/In press) In: British Journal of Nutrition.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches

  Hasan, A., Al-Ozairi, E., Al-Baqsumi, Z., Ahmad, R. & Al-Mulla, F., 2021, In: ImmunoTargets and Therapy. 10, p. 63-85 23 p.

  Research output: Contribution to journal › Review article › peer-review

• Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells

  Al-Rashed, F., Ahmad, Z., Snider, A. J., Thomas, R., Kochumon, S., Melhem, M., Sindhu, S., Obeid, L. M., Al-Mulla, F., Hannun, Y. A. & Ahmad, R., 15 Apr 2021, In: Scientific Reports. 11, 1, p. 8259 1 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Clinical characteristics and outcomes of COVID-19 patients with diabetes mellitus in Kuwait

  Alshukry, A., Bu Abbas, M., Ali, Y., Alahmad, B., Al-Shammari, A. A., Alhamar, G., Abu-Farha, M., AbuBaker, J., Devarajan, S., Dashti, A. A., Al-Mulla, F. & Ali, H., Apr 2021, In: Heliyon. 7, 4, p. e06706 e06706.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in Kuwait

  Dashti, M., Alsaleh, H., Eaaswarkhanth, M., John, S. E., Nizam, R., Melhem, M., Hebbar, P., Sharma, P., Al-Mulla, F. & Thanaraj, A. T., 11 Feb 2021, In: Frontiers in Genetics. 12, 626260, p. 626260 12 p., 626260.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Early insight into antibody-dependent enhancement after SARS-CoV-2 mRNA vaccination

  Hasan, A., Al-Mulla, M. R., Abubaker, J. & Al-Mulla, F., 20 Sep 2021, (E-pub ahead of print) In: Human Vaccines and Immunotherapeutics. p. 1-5 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Editorial: Diabetes in the Middle East

  Abu-Farha, M., Tuomilehto, J. & Abubaker, J., 2021, In: Frontiers in Endocrinology. 12, p. 638653

  Research output: Contribution to journal › Article › peer-review

• Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals

  Al-Rashed, F., Sindhu, S., Al Madhoun, A., Ahmad, Z., AlMekhled, D., Azim, R., Al-Kandari, S., Wahid, M. A-A., Al-Mulla, F. & Ahmad, R., 6 Jul 2021, In: Scientific Reports. 11, 1, p. 13883

  Research output: Contribution to journal › Article › peer-review

• Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

  Imperial College London, 9 Mar 2021, In: eLife. 10, e60060.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Higher BDNF Levels in the Circulation is Associated with Angiogenesis, Inflammatory and Metabolic Biomarkers in Children

  Hasan, A., Kochumon, S., Ali, S. & Mandani, F., Apr 2021.

  Research output: Contribution to conference › Poster › peer-review

• Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data

  Khan, A., Zia, T., Suleman, M., Khan, T., Ali, S. S., Abbasi, A. A., Mohammad, A. & Wei, D. Q., 23 Mar 2021, (E-pub ahead of print) In: Journal of Cellular Physiology.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Identification of Maturity-Onset-Diabetes of the Young (MODY) mutations in a country where diabetes is endemic

  Al-Kandari, H., Al-Abdulrazzaq, D., Davidsson, L., Nizam, R., Jacob, S., Melhem, M., John, S. E. & Al-Mulla, F., Dec 2021, In: Scientific Reports. 11, 1, 16060.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Immunogenomics guided design of immunomodulatory multi-epitope subunit vaccine against the SARS-CoV-2 new variants, and its validation through in silico cloning and immune simulation

  Khan, A., Khan, S., Saleem, S., Nizam-Uddin, N., Mohammad, A., Khan, T., Ahmad, S., Arshad, M., Ali, S. S., Suleman, M. & Wei, D. Q., Jun 2021, In: Computers in Biology and Medicine. 133, p. 104420 104420.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment

  Arefanian, H., Al-Khairi, I., Khalaf, N. A., Cherian, P., Kavalakatt, S., Madhu, D., Mathur, A., Qaddoumi, M. G., Al-Mulla, F., Abubaker, J. & Abu-Farha, M., Dec 2021, In: Lipids in Health and Disease. 20, 1, p. 117 117.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Interleukin-6 to Transforming Growth Factor-β Ratio is Associated with Obesity and Systemic Inflammation in Children

  Hasan, A., Kochumon, S., Ali, S. & Mandani, F., 9 Jun 2021.

  Research output: Contribution to conference › Poster › peer-review

• IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis

  Yan, S., Kumari, M., Xiao, H., Jacobs, C., Kochumon, S., Jedrychowski, M., Chouchani, E., Ahmad, R. & Rosen, E. D., 1 Apr 2021, In: Journal of Clinical Investigation. 131, 7, e144888.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells

  Al Madhoun, A., Haddad, D., Al Tarrah, M., Jacob, S., Al-Ali, W., Nizam, R., Miranda, L., Al-Rashed, F., Sindhu, S., Ahmad, R., Bitar, M. S. & Al-Mulla, F., 4 Jun 2021, In: Scientific Reports. 11, 1, p. 11893

  Research output: Contribution to journal › Article › peer-review

• Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population

  Dashti, M., Alsaleh, H., Rodriguez-Flores, J. L., Eaaswarkhanth, M., Al-Mulla, F. & Thanaraj, T. A., 13 Jan 2021, In: Scientific Reports. 11, 1, p. 1091 1091.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Molecular simulation-based investigation of highly potent natural products to abrogate formation of the nsp10–nsp16 complex of sars-cov-2

  Mohammad, A., Alshawaf, E., Marafie, S. K., Abu-Farha, M., Al-Mulla, F. & Abubaker, J., Apr 2021, In: Biomolecules. 11, 4, 573.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Neutral sphingomyelinase-2 and cardiometabolic diseases

  Sindhu, S., Leung, Y. H., Arefanian, H., Madiraju, S. R. M., Al-Mulla, F., Ahmad, R. & Prentki, M., 2021, (Accepted/In press) In: Obesity Reviews.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• New Mammalian Glycerol-3-Phosphate Phosphatase: Role in β-Cell, Liver and Adipocyte Metabolism

  Possik, E., Al-Mass, A., Peyot, M-L., Ahmad, R., Al-Mulla, F., Madiraju, S. R. M. & Prentki, M., 13 Jul 2021, In: Frontiers in Endocrinology. 12, p. 706607

  Research output: Contribution to journal › Review article › peer-review

• Obesity and Prediabetes are Jointly Associated with Lipid Abnormalities Among Adolescents: A Cross-Sectional Study

  Almari, M., Mohammad, A., Abubaker, J. & Ziyab, A. H., 2021, In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 14, p. 345-353 9 p.

  Research output: Contribution to journal › Article › peer-review

• Outcomes of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists in kidney transplant recipients with diabetes

  Mahmoud, T., Yagan, J., Hasan, A., Gheith, O., Mustafa, M., Rida, S., Elserwy, N., Shaker, M., Khaled, M., Nair, P. & Alotaibi, T., 2021, (Accepted/In press).

  Research output: Contribution to conference › Abstract › peer-review

• Pharmaku: A web-based tool aimed at improving outreach and clinical utility of pharmacogenomics

  John, S. E., Channanath, A. M., Hebbar, P., Nizam, R., Thanaraj, T. A. & Al-Mulla, F., Mar 2021, In: Journal of Personalized Medicine. 11, 3, 210.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Preliminary Structural Data Revealed That the SARS-CoV-2 B.1.617 Variant's RBD Binds to ACE2 Receptor Stronger Than the Wild Type to Enhance the Infectivity

  Khan., A., Wei, D. Q., Kousar, K., Abubaker, J., Ahmad, S., Ali, J., Al-Mulla, F., Ali, S. S., Nizam-Uddin, N., Mohammad Sayaf, A. & Mohammad, A., 23 Jun 2021, (E-pub ahead of print) In: ChemBioChem.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Prevalence, Risk Factors, and Comorbidities of Obstructive Sleep Apnea Risk Among a Working Population in Kuwait: A Cross-Sectional Study

  Al-Qattan, H., Al-Omairah, H., Al-Hashash, K., Al-Mutairi, F., Al-Mutairat, M., Al-Ajmi, M., Mohammad, A., Alterki, A. & Ziyab, A. H., 6 Apr 2021, In: Frontiers in Neurology. 12, p. 620799 620799.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Prevalence of overweight and obesity, and associations with socio-demographic factors in Kuwait

  Oguoma, V. M., Coffee, N. T., Alsharrah, S., Abu-Farha, M., Al-Refaei, F. H., Al-Mulla, F. & Daniel, M., 7 Apr 2021, In: BMC Public Health. 21, 1, p. 667

  Research output: Contribution to journal › Article › peer-review

• Prevalence of prediabetes and undiagnosed diabetes among kuwaiti adults: A cross-sectional study

  Mohammad, A., Ziyab, A. H. & Mohammad, T., 2021, In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 14, p. 2167-2176 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Profiling of Insulin-Like Growth Factor Binding Proteins (IGFBPs) in Obesity and Their Association With Ox-LDL and Hs-CRP in Adolescents

  Rahman, A., Hammad, M. M., Al Khairi, I., Cherian, P., Al-Sabah, R., Al-Mulla, F., Abu-Farha, M. & Abubaker, J., 28 Jul 2021, In: Frontiers in Endocrinology. 12, 727004.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Relevance between COVID-19 and host genetics of immune response

  Taher, I., Almaeen, A., Ghazy, A., Abu-Farha, M., Mohamed Channanath, A., Elsa John, S., Hebbar, P., Arefanian, H., Abubaker, J., Al-Mulla, F. & Alphonse Thanaraj, T., 17 Jul 2021, (E-pub ahead of print) In: Saudi Journal of Biological Sciences.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

• Remdesivir md simulations suggest a more favourable binding to sars-cov-2 rna dependent rna polymerase mutant p323l than wild-type

  Mohammad, A., Al-Mulla, F., Wei, D. Q. & Abubaker, J., Jul 2021, In: Biomolecules. 11, 7, 919.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Risk of mortality among inpatients with COVID-19 and type 2 diabetes: National data from Kuwait

  Al-Ozairi, E., Brown, R., Hamdan, Y., Alabdullah, L., Voase, N., Al Kandari, J., Alsaeed, D., Al Ozairi, A., Hasan, A., Al-Mulla, F., Katikireddi, S. V., Gray, S. R., Gill, J. M. R., Celis-Morales, C. A., Sattar, N. & Welsh, P., 10 Jul 2021, (E-pub ahead of print) In: Endocrinology, Diabetes and Metabolism. p. e00287

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Salivary Microbiome Diversity in Kuwaiti Adolescents with Varied Body Mass Index—A Pilot Study

  Alqaderi, H., Ramakodi, M. P., Nizam, R., Jacob, S., Sriraman, D., Eaaswarkhanth, M. & Al-Mulla, F., 4 Jun 2021, In: Microorganisms. 9, 6, p. 1-13 13 p., 1222.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains

  Haddad, D., John, S. E., Mohammad, A., Hammad, M. M., Hebbar, P., Channanath, A., Nizam, R., Al-Qabandi, S., Madhoun, A. A., Alshukry, A., Ali, H., Thanaraj, T. A. & Al-Mulla, F., May 2021, In: PloS one. 16, 5 May, e0251368.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Serum IRAP, a Novel Direct Biomarker of Prediabetes and Type 2 Diabetes?

  Trocmé, C., Gonnet, N., Di Tommaso, M., Samouda, H., Cracowski, J. L., Cracowski, C., Lambert-Porcheron, S., Laville, M., Nobécourt, E., Gaddhab, C., Le Lay, A., Bohn, T., Poitou, C., Clément, K., Al-Mulla, F., Bitar, M. S. & Bottari, S. P., 16 Feb 2021, In: Frontiers in Molecular Biosciences. 7, 596141.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis

  Al-Roub, A., Akhter, N., Al-Sayyar, A., Wilson, A., Thomas, R., Kochumon, S., Al-Rashed, F., Al-Mulla, F., Sindhu, S. & Ahmad, R., 19 Jul 2021, In: International Journal of Molecular Sciences. 22, 14

  Research output: Contribution to journal › Article › peer-review

• Short sleep duration and its association with obesity and other metabolic risk factors in Kuwaiti urban adults

  Al-Rashed, F., Sindhu, S., Madhoun, A. A., Alghaith, A., Azim, R., Al-Mulla, F. & Ahmad, R., 2021, In: Nature and Science of Sleep. 13, p. 1225-1241 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Structural modelling of SARS-CoV-2 alpha variant (B.1.1.7) suggests enhanced furin binding and infectivity

  Mohammad, A., Abubaker, J. & Al-Mulla, F., 24 Jul 2021, (E-pub ahead of print) In: Virus Research. 303, p. 198522

  Research output: Contribution to journal › Article › peer-review

• Synergistic induction of TNF-α by palmitate and oxidative stress in human monocytic cells involves the NF-κB/p38 MAPK signaling

  Sindhu, S., Akther, N., Wilson, A., Al-Rashed, F., Al Madhoun, A., Arefanian, H., Al-Mulla, F. & Ahmad, R., 2021.

  Research output: Contribution to conference › Poster › peer-review

• The Impact of Coronavirus COVID-19 Pandemic on Food Purchasing, Eating Behavior, and Perception of Food Safety in Kuwait

  AlTarrah, D., AlShami, E., Al-Hamad, N., AlBesher, F. & Sriraman, D., 11 Aug 2021, In: Sustainability. 13, 8987, 13168987.

  Research output: Contribution to journal › Article › peer-review

• The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels

  AlTerki, A., Alshawaf, E., Al Khairi, I., Cherian, P., Sriraman, D., Hammad, M., Thanaraj, A. T., Ebrahim, M. A. K., Al-Mulla, F., Abu-Farha, M. & Abubaker, J., 4 Oct 2021, In: Disease Markers. 2021, 1219593.

  Research output: Contribution to journal › Article › peer-review

• TNF-α increases ip-10 expression in MCF-7 breast cancer cells via activation of the JNK/c-jun pathways

  Kochumon, S., Al-Sayyar, A., Jacob, T., Hasan, A., Al-Mulla, F., Sindhu, S. & Ahmad, R., 13 Sep 2021, In: Biomolecules. 11, 9, 1355.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• TNF-α stimulation under oxidative stress augments the expression of monocyte chemoattractant protein (MCP)-1 in THP-1 cells via the NF-κB/ERK1-2 mediated signaling

  Sindhu, S., Akhter, N., Wilson, A., Thomas, R., Al-Rashed, F., Abu-AlRoub, A., Arefanian, H., Al Madhoun, A., Al-Mulla, F. & Ahmad, R., 2021.

  Research output: Contribution to conference › Poster › peer-review

• Unraveling a fine-scale high genetic heterogeneity and recent continental connections of an Arabian Peninsula population

  Eaaswarkhanth, M., Pathak, A., Ongaro, L., Montinaro, F., Hebbar, P., Alsmadi, O., Metspalu, M., Al-Mulla, F. & Thanaraj, A. T., 22 Mar 2021, In: European Journal of Human Genetics. p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes

  Kavalakatt, S., Khadir, A., Madhu, D., Koistinen, H. A., Al-Mulla, F., Tuomilehto, J., Abubaker, J. & Tiss, A., 2 Aug 2021, In: Scientific Reports. 11, 1, p. 15666

  Research output: Contribution to journal › Article › peer-review

• Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

  Imperial College London, 11 Sep 2021, In: The Lancet. 398, 10304, p. 957-980 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)
• 2020

  A comprehensive germline variant and expression analyses of ACE2, TMPRSS2 and SARS-CoV-2 activator FURIN genes from the Middle East: Combating SARS-CoV-2 with precision medicine

  Al-Mulla, F., Mohammad, A., Al Madhoun, A., Haddad, D., Ali, H., Eaaswarkhanth, M., John, S. E., Nizam, R., Channanath, A., Abu-Farha, M., Ahmad, R., Abubaker, J. & Thanaraj, A. T., 16 May 2020, In: BioRxiv. BIORXIV/2020/099176, p. 1 to 28 28 p.

  Research output: Contribution to journal › Article

  Open Access

• Adaptive fitness advantage in ancestors: a major health risk to a present-day Arab population

  Eaaswarkhanth, M., Campelo dos Santos, A. L., Gokcumen, O., Al-Mulla, F. & Thanaraj, A. T., 20 Apr 2020.

  Research output: Contribution to conference › Poster › peer-review

  Open Access