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2017

Decreased level of plasma fibroblast growth factor (FGF) acidic in people with Obstructive Sleep Apnea.

Abu-Farha, M., Cherian, P., Al Khairi, I., Sriraman, D., Mathur, A., Alhubail, A., Tuomilehto, J., Abubaker, J. & Al-Terki, A., 2017.

Research output: Contribution to conferencePoster

Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation

Núñez-Toldrà, R., Martínez-Sarrà, E., Gil-Recio, C., Carrasco, M. Á., Al Madhoun, A., Montori, S. & Atari, M., 21 Apr 2017, In : BMC Cell Biology. 18, 1, 21.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Determinants of the increase in ketone concentration during SGLT2 inhibition in NGT, IFG and T2DM patients

Al Jobori, H., Daniele, G., Adams, J., Cersosimo, E., Triplitt, C., DeFronzo, R. A. & Abdulghani, M., 1 Jun 2017, In : Diabetes, Obesity and Metabolism. 19, 6, p. 809-813 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
3 Citations (Scopus)

Efficacy of exenatide plus pioglitazone vs basal/bolus insulin in T2DM patients with very high HbA1c

Abdulghani, M., Migahid, O., Megahed, A., DeFronzo, R. A., Zirie, M. & Jayyousi, A., 1 Jul 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2162-2170 9 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes

Al-Jobori, H., Daniele, G., Cersosimo, E., Triplitt, C., Mehta, R., Norton, L., DeFronzo, R. A. & Abdulghani, M., 1 Jul 2017, In : Diabetes. 66, 7, p. 1999-2006 8 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study

Channanath, A., Elkum, N., Mahmoud Yousef Alabdulrazzaq, D., Tuomilehto, J., Shaltout, A. & Thanaraj, A. T., 1 Apr 2017, In : PloS one. 12, 4, e0175728.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Exome sequencing for the differential diagnosis of ciliary chondrodysplasias: Example of a WDR35 mutation case and review of the literature

Antony, D., Nampoory, N., Bacchelli, C., Melhem, M., Wu, K., James, C. T., Beales, P. L., Hubank, M., Thomas, D., Mashankar, A., Behbehani, K., Schmidts, M. & Alsmadi, O., 1 Dec 2017, In : European Journal of Medical Genetics. 60, 12, p. 658-666 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: A birth cohort study

H M Ziyab, A., Ewart, S., Lockett, G. A., Zhang, H., Arshad, H., Holloway, J. W. & Karmaus, W., 1 Sep 2017, In : Clinical and Experimental Allergy. 47, 9, p. 1185-1192 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Fasting Betatrophin, 1-year post Laparoscopic Sleeve Gastrectomy, a correlation to beta cell function & T2DM remission

Alshawaf, E., Al Ozairi, E., Al-Asfar, F. & Arefanian, H., 4 Dec 2017.

Research output: Contribution to conferencePoster

Functional foods and lifestyle approaches for diabetes prevention and management

Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A. & Tuomilehto, J., 1 Dec 2017, In : Nutrients. 9, 12, 1310.

Research output: Contribution to journalReview article

Open Access
52 Citations (Scopus)
Open Access
5 Citations (Scopus)

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10

Zhang, W., Sartori, M. A., Makhnevych, T., Federowicz, K. E., Dong, X., Liu, L., Nim, S., Dong, A., Yang, J., Li, Y., Haddad, D., Ernst, A., Heerding, D., Tong, Y., Moffat, J. & Sidhu, S. S., 10 Nov 2017, In : Journal of Molecular Biology. 429, 22, p. 3546-3560 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Genetic association of ITPR3 SNP rs999943 with Type 2 Diabetes and related metabolic traits

Mahmoud Kamkar, M., Nizam, R. & Hasan, S., 16 Nov 2017, International Diabetes Federation 2017 Congress.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Genetic Risk Prediction using Family Health History Approach

Mahmoud Kamkar, M., Sriraman, D. & Thomas, D., 2017.

Research output: Contribution to conferencePoster

Genetic risk variants for metabolic traits in Arab populations

Hebbar, P., Elkum, N., Alkayal, F., John, S. E., Thanaraj, A. T. & Alsmadi, O., 20 Jan 2017, In : Scientific Reports. 7, 40988.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Genetic variants associated with warfarin dosage in Kuwaiti population

John, S. E., Antony, D., Eaaswarkhanth, M., Hebbar, P., Alkayal, F., Tuomilehto, J., Alsmadi, O. & Thanaraj, A. T., 1 Jun 2017, In : Pharmacogenomics. 18, 8

Research output: Contribution to journalArticle

3 Citations (Scopus)

Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance

Chen, H., Bai, J., Dong, F., Fang, H., Zhang, Y., Meng, W., Liu, B., Luo, Y., Liu, M., Bai, Y., Abdulghani, M., Li, R., Wu, J., Zeng, R., Zhou, Z., Dong, L. Q. & Liu, F., 1 Jun 2017, In : FASEB Journal. 31, 6, p. 2314-2326 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Higher level of Oxidized LDL circulation level in humans with Obstructive Sleep Apnea.

Al-Terki, A., Al Khairi, I., Sriraman, D., Shyamsundar, A., Warsam, S., Cherian, P., Abu-Farha, M., Tuomilehto, J. & Abubaker, J., 2017.

Research output: Contribution to conferencePoster

Identification of a rare germline NBN gene mutation by whole exome sequencing in a lung-cancer survivor from a large family with various types of cancer

Marafie, M. J., Dashti, M. & Al-Mulla, F., 1 Jul 2017, In : Familial Cancer. 16, 3, p. 389-394 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Impact of ethnicity and obesity on insulin resistance in two ethnic groups at very high risk of type 2 diabetes

Hassoun, S., Al-Atrash, M., Alkasim, M., Dabbous, Z., Mujahed, O., DeFronzo, R. A., Jayyousi, A., Zirie, M. & Abdulghani, M., 1 Jun 2017, In : Diabetes and Metabolism. 43, 3, p. 292-294 3 p.

Research output: Contribution to journalLetter

3 Citations (Scopus)

Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years

Shaltout, A. A., Wake, D., Thanaraj, A. T., Omar, D. M., Mahmoud Yousef Alabdulrazzaq, D., Channanath, A., Mohammad Abdullah Al-kandari, H., Abdulrasoul, M., Miller, S., Conway, N., Tuomilehto, J. & Davidsson, L., 1 Dec 2017, In : Pediatric Diabetes. 18, 8, p. 761-766 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
Open Access
11 Citations (Scopus)

Increased Angiopoietin Like protein (ANGPTL) 4 and 8 circulation levels in people with Obstructive Sleep Apnea

Abubaker, J., Sriraman, D., Cherian, P., Al Khairi, I., Alhubail, A., Al Shaar, N., Tuomilehto, J. & Al-Terki, A., 2017.

Research output: Contribution to conferencePoster

Open Access
16 Citations (Scopus)

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects

Eldor, R., Norton, L., Fourcaudot, M., Galindo, C., DeFronzo, R. A. & Abdulghani, M., 1 Dec 2017, In : PloS one. 12, 12, e0188208.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Inducible CTCF insulator delays the IgH 3' regulatory region-mediated activation of germline promoters and alters class switching

Braikia, F. Z., Oudinet, C., Haddad, D., Oruc, Z., Orlando, D., Dauba, A., Le Bert, M. L. & Khamlichi, A. A., 6 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. 6092-6097 6 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Infant and young child feeding patterns in Kuwait: Results of a cross-sectional survey

Carballo, M., Khatoon, N., Maclean, E. C., Al-Hamad, N., Mohammad, A., Al-Wotayan, R. & Abraham, S., 1 Aug 2017, In : Public Health Nutrition. 20, 12, p. 2201-2207 7 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Inhibition of renal sodium-glucose cotransport with empagliflozin lowers fasting plasma glucose and improves β-cell function in subjects with impaired fasting glucose

Abdulghani, M., Al Jobori, H., Daniele, G., Adams, J., Cersosimo, E., Triplitt, C. & DeFronzo, R. A., 1 Sep 2017, In : Diabetes. 66, 9, p. 2495-2502 8 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Insulin-associated weight gain in obese type 2 diabetes mellitus patients: What can be done?

Brown, A., Guess, N., Dornhorst, A., Taheri, S. & Frost, G., 1 Dec 2017, In : Diabetes, Obesity and Metabolism. 19, 12, p. 1655-1668 14 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Is it time to change the type 2 diabetes treatment paradigm? Yes! GLP-1 ras should replace metformin in the type 2 diabetes algorithm

Abdulghani, M. & DeFronzo, R. A., 1 Aug 2017, In : Diabetes care. 40, 8, p. 1121-1127 7 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Medical and pharmacy students’ attitudes towards physician-pharmacist collaboration in Kuwait

Katoue, M. G., Awad, A. I., Al-Jarallah, A., Al Ozairi, E. & Schwinghammer, T. L., 1 Jul 2017, In : Pharmacy Practice. 15, 3, 1029.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

National Dasman Diabetes Biobank - A Research Horizon

Sriraman, D., Lopez, V., Mathur, A., Chandy, B., Shyamsundar, A., Jose, R. M., Vijayan, V., Shiju, R., AlKandari, S., Marimuthu, V., Mahmoud Kamkar, M. & Tuomilehto, J., 2017.

Research output: Contribution to conferencePoster

National Diabetes Biobank – An overview.

Sriraman, D., Lopez, V., Mathur, A., Chandy, B. S., Shyamsundar, A., Jose, R. M., Vijayan, V., Mahmoud Kamkar, M. & Tuomilehto, J., 2017.

Research output: Contribution to conferencePoster

Next-generation sequencing in familial breast cancer patients from Lebanon

Jalkh, N., Chouery, E., Haidar, Z., Khater, C., Atallah, D., Mohamed Ali Yaseen, H., Marafie, M. J., Al-Mulla, M. R., Al-Mulla, F. & Megarbane, A., 15 Feb 2017, In : BMC Medical Genomics. 10, 1, p. 1-12 12 p., 8.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

NHS Diabetes Prevention Programme is vital but criteria need reviewing

Guess, N., 1 Jan 2017, In : BMJ (Online). 356, j993.

Research output: Contribution to journalLetter

Normal Reference Ranges for Pulmonary Artery Diameters in Preterm Infants

Abushaban, L., Vel, M. T., Rathinasamy, J. & Sharma, P., 1 Oct 2017, In : Pediatric Cardiology. 38, 7, p. 1377-1384 8 p.

Research output: Contribution to journalArticle

Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia

Melhem, M., Abu-Farha, M., Antony, D., Al Madhoun, A., Bacchelli, C., Alkayal, F., Al khairi, I., John, S. E., Alomari, M., Beales, P. L. & Alsmadi, O., 1 Mar 2017, In : European Journal of Haematology. 98, 3, p. 218-227 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis

Behbehani, R., Al-Hassan, A. A., Al-Salahat, A., Sriraman, D., Oakley, J. D. & Alroughani, R., 1 Feb 2017, In : PloS one. 12, 2, e0172120.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Pam3CSK4 induces MMP-9 expression in human monocytic THP-1 cells

Salem Alrashed, F., Kchumon, S., Usmani, S., Sindhu, S. & Ahmad, R., 1 Jun 2017, In : Cellular Physiology and Biochemistry. 41, 5, p. 1993-2003 11 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Pheochromocytoma in pregnancy: The art of balancing risks for an optimal outcome.

Alsharefi, A. & Aldibbiat, A. M., 2017.

Research output: Contribution to conferencePoster

Pioglitazone improves left ventricular diastolic function in subjects with diabetes

Clarke, G. D., Solis-Herrera, C., Molina-Wilkins, M., Martinez, S., Merovci, A., Cersosimo, E., Chilton, R. J., Iozzo, P., Gastaldelli, A., Abdulghani, M. & DeFronzo, R. A., 1 Nov 2017, In : Diabetes care. 40, 11, p. 1530-1536 7 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes

Shannon, C. E., Daniele, G., Galindo, C., Abdulghani, M., DeFronzo, R. A. & Norton, L., 1 Feb 2017, In : FEBS Journal. 284, 3, p. 451-465 15 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise

Abu-Farha, M., Cherian, P., Al khairi, I., Madhu, D., Tiss, A., Warsam, S., Alhubail, A., Sriraman, D., Al-Refaei, F. & Abubaker, J., 1 Mar 2017, In : PloS one. 12, 3, e0173024.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

PLXNA3 Variant rs5945430 is Associated with Severe Clinical Course in Male Multiple Sclerosis Patients

Qureshi, M., Hatem, M., Alroughani, R., Jacob, S. & Al-Temaimi, R. A., 1 Sep 2017, In : NeuroMolecular Medicine. 19, 2-3, p. 286-292 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
16 Citations (Scopus)

Prevalence of joint hypermobility in Kuwait

Al-Jarallah, K., Shehab, D., Al-Jaser, M. T., Al-Azemi, K. M., Wais, F. F., Al-Saleh, A. M., Al-Ajmi, A. S., Al-Omairah, H. A., Abraham, M. & Sharma, P., 1 Aug 2017, In : International Journal of Rheumatic Diseases. 20, 8, p. 935-940 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Reduced hypoxia and improved beta cell function in optimised long term rotational culture conditions

Aljahdami, N., Shaw, J. A. M. & Aldibbiat, A. M., 2017.

Research output: Contribution to conferencePoster

Reduced levels of MicroRNAs 143 and 181d (mir-143 and mir-181d) in Obesity

Cherian, P., Al Khairi, I., Abubaker, J., Abu-Farha, M., Alkandari, A. & Tuomilehto, J., 4 Dec 2017.

Research output: Contribution to conferencePoster