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2016

Supporting the information domains of fall-risk management in home care via health information technology

Alhuwail, D., Koru, G. & Mills, M. E., 1 Oct 2016, In : Home Health Care Services Quarterly. 35, 3-4, p. 155-171 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The effect of dietary changes on distinct components of the metabolic syndrome in a young Sri Lankan population at high risk of CVD

Guess, N., Wijesuriya, M., Vasantharajah, L., Gulliford, M., Viberti, G., Gnudi, L. & Karalliedde, J., 28 Aug 2016, In : British Journal of Nutrition. 116, 4, p. 719-727 9 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The oral-systemic disease connection: a retrospective study

Joseph, B. K., Kullman, L. & Sharma, P., 1 Nov 2016, In : Clinical Oral Investigations. 20, 8, p. 2267-2273 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
Open Access
7 Citations (Scopus)

The role of Gut Microbiota in the development of obesity and Diabetes

Baothman, O. A., Zamzami, M. A., Taher, I., Abubaker, J. & Abu-Farha, M., 18 Jun 2016, In : Lipids in Health and Disease. 15, 1, 108.

Research output: Contribution to journalReview article

Open Access
130 Citations (Scopus)

The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation

Ramachandran, S., Haddad, D., Li, C., Le, M. X., Ling, A. K., So, C. C., Nepal, R. M., Gommerman, J. L., Yu, K., Ketela, T., Moffat, J. & Martin, A., 17 May 2016, In : Cell Reports. 15, 7, p. 1554-1565 12 p.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Total energy expenditure in obese kuwaiti primary school children assessed by the doubly-labeled water technique

Davidsson, L., Al-Ghanim, J., Al-Ati, T., Al-Hamad, N., Al-Mutairi, A., Al-Olayan, L. & Preston, T., 1 Oct 2016, In : International Journal of Environmental Research and Public Health. 13, 10, 1007.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Uncommon TERT promoter mutations in pediatric thyroid cancer

Alzahrani, A. S., Qasem, E., Murugan, A. K., Al-Hindi, H. N., Alkhafaji, D., Almohanna, M., Xing, M., Saqer Hamad Alhmaidah, D. & Alswailem, M., 1 Feb 2016, In : Thyroid. 26, 2, p. 235-241 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Unraveling Kuwait-specific metabolic gene regulatory and coding variants: a step towards building a national exome database

Nizam, R., Antony, DI., John, S. E., Hebbar, P., Melhem, M., Tuomilehto, J., Thanaraj, A. T. & Alsmadi, O., Dec 2016, WCPD9 Abstracts. Endocr Pract, Vol. 22 (suppl 6). p. 1-29

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Use of shadow for enhancing mapping of perennial desert plants from high-spatial resolution multispectral and panchromatic satellite imagery

Alsharrah, S., Bouabid, R., Bruce, D. A., Somenahalli, S. & Corcoran, P. A., 1 Jul 2016, In : Journal of Applied Remote Sensing. 10, 3, 036008.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Variation of skin in recent human evolution: Loss of function and structural variation affecting filaggrin gene

Eaaswarkhanth, M., Xu, D., Rzhetskaya, M., Hayes, M. G. & Gokcumen, O., 15 Apr 2016.

Research output: Contribution to conferenceAbstract

2015
Open Access
10 Citations (Scopus)

Adherence to NICE guidelines on diabetes prevention in the UK: Effect on patient knowledge and perceived risk

Guess, N., Caengprasath, N., Dornhorst, A. & Frost, G. S., 1 Dec 2015, In : Primary Care Diabetes. 9, 6, p. 407-411 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

An audit of Inpatient Diabetes Team activity in a District General Hospital: assessment of effectiveness and impact

Aldibbiat, A. M., Nash, E., Qurban, R., Sing, M., Pickering, S., Mellgaard, S., Willimas, C., Tarigopula, G., Partha, P. & Peter, P., 2015.

Research output: Contribution to conferencePoster

A novel PKD1 variant demonstrates a disease-modifying role in trans with a truncating PKD1 mutation in patients with Autosomal Dominant Polycystic Kidney Disease

Mohamed Ali Yaseen, H., Hussain, N., Naim, M., Zayed, M., Al-Mulla, F., Kehinde, E. O., Seaburg, L. M., Sundsbak, J. L. & Harris, P. C., 1 Dec 2015, In : BMC Nephrology. 16, 1, 26.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

A randomized controlled trial: The effect of inulin on weight management and ectopic fat in subjects with prediabetes

Guess, N., Dornhorst, A., Oliver, N., Bell, J. D., Thomas, E. L. & Frost, G. S., 24 Oct 2015, In : Nutrition and Metabolism. 12, 1, 36.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

Goodson, W. H., Lowe, L., Carpenter, D. O., Gilbertson, M., Ali, A. M., de Cerain Salsamendi, A. L., Lasfar, A., Carnero, A., Azqueta, A., Amedei, A., Charles, A. K., Collins, A. R., Ward, A., Salzberg, A. C., Colacci, A., Olsen, A. K., Berg, A., Barclay, B. J., Zhou, B. P., Blanco-Aparicio, C. & 153 others, Baglole, C. J., Dong, C., Mondello, C., Hsu, C. W., Naus, C. C., Yedjou, C., Curran, C. S., Laird, D. W., Koch, D. C., Carlin, D. J., Felsher, D. W., Roy, D., Brown, D. G., Ratovitski, E., Ryan, E. P., Corsini, E., Rojas, E., Moon, E. Y., Laconi, E., Marongiu, F., Al-Mulla, F., Chiaradonna, F., Darroudi, F., Martin, F. L., Van Schooten, F. J., Goldberg, G. S., Wagemaker, G., Nangami, G., Calaf, G. M., Williams, G., Wolf, G. T., Koppen, G., Brunborg, G., Kim Lyerly, H., Krishnan, H., Hamid, H. A., Yasaei, H., Sone, H., Kondoh, H., Salem, H. K., Hsu, H. Y., Park, H. H., Koturbash, I., Miousse, I. R., Ivana Scovassi, A., Klaunig, J. E., Vondráček, J., Raju, J., Roman, J., Wise, J. P., Whitfield, J. R., Woodrick, J., Christopher, J. A., Ochieng, J., Martinez-Leal, J. F., Weisz, J., Kravchenko, J., Sun, J., Prudhomme, K. R., Narayanan, K. B., Cohen-Solal, K. A., Moorwood, K., Gonzalez, L., Soucek, L., Jian, L., D'Abronzo, L. S., Lin, L. T., Li, L., Gulliver, L., McCawley, L. J., Memeo, L., Vermeulen, L., Leyns, L., Zhang, L., Valverde, M., Khatami, M., Romano, M. F., Chapellier, M., Williams, M. A., Wade, M., Manjili, M. H., Lleonart, M., Xia, M., Gonzalez, M. J., Karamouzis, M. V., Kirsch-Volders, M., Vaccari, M., Kuemmerle, N. B., Singh, N., Cruickshanks, N., Kleinstreuer, N., Van Larebeke, N., Ahmed, N., Ogunkua, O., Krishnakumar, P. K., Vadgama, P., Marignani, P. A., Ghosh, P. M., Ostrosky-Wegman, P., Thompson, P., Dent, P., Heneberg, P., Darbre, P., Leung, P. S., Nangia-Makker, P., Cheng, Q. S., Brooks Robey, R., Al-Temaimi, R., Roy, R., Andrade-Vieira, R., Sinha, R. K., Mehta, R., Vento, R., Di Fiore, R., Ponce-Cusi, R., Dornetshuber-Fleiss, R., Nahta, R., Castellino, R. C., Palorini, R., Hamid, R. A., Langie, S. A. S., Eltom, S., Brooks, S. A., Ryeom, S., Wise, S. S., Bay, S. N., Harris, S. A., Papagerakis, S., Romano, S., Pavanello, S., Eriksson, S., Forte, S., Casey, S. C., Luanpitpong, S., Lee, T. J., Otsuki, T., Chen, T., Massfelder, T., Sanderson, T., Guarnieri, T., Hultman, T., Dormoy, V., Odero-Marah, V., Sabbisetti, V., Maguer-Satta, V., Kimryn Rathmell, W., Engström, W., Decker, W. K., Bisson, W. H., Rojanasakul, Y., Luqmani, Y., Chen, Z. & Hu, Z., 1 Jun 2015, In : Carcinogenesis. 36, p. S254-S296

Research output: Contribution to journalArticle

Open Access
125 Citations (Scopus)

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: Focus on the cancer hallmark of tumor angiogenesis

Hu, Z., Brooks, S. A., Dormoy, V., Hsu, C. W., Hsu, H. Y., Lin, L. T., Massfelder, T., Kimryn Rathmell, W., Xia, M., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Brown, D. G., Prudhomme, K. R., Colacci, A., Hamid, R. A., Mondello, C., Raju, J., Ryan, E. P., Woodrick, J. & 11 others, Ivana Scovassi, A., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L., Salem, H. K., Lowe, L., Jensen, L., Bisson, W. H. & Kleinstreuer, N., 1 Jun 2015, In : Carcinogenesis. 36, p. S184-S202

Research output: Contribution to journalReview article

Open Access
17 Citations (Scopus)
Open Access
9 Citations (Scopus)

Associations of TERC single nucleotide polymorphisms with human leukocyte telomere length and the risk of type 2 diabetes mellitus

Al Khaldi, R., Mojiminiyi, O., Al-Mulla, F. & Abdella, N., 1 Dec 2015, In : PloS one. 10, 12, e0145721.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

A voxel-based morphometric magnetic resonance imaging study of the brain detects age-related gray matter volume changes in healthy subjects of 21-45 years old

KH H Bourisly, A., El-Beltagi, A., Cherian, J., Gejo, G., Al-Jazzaf, A. & Ismail, M., 1 Oct 2015, In : Neuroradiology Journal. 28, 5, p. 450-459 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Balancing the benefits and risks of iron fortification in resource-constrained settings

Zlotkin, S. H., Davidsson, L. & Lozoff, B., 1 Oct 2015, In : Journal of Pediatrics. 167, 4, p. S26-S30

Research output: Contribution to journalArticle

2 Citations (Scopus)

Bariatric Surgery, with a surprise!.

Aldibbiat, A. M., Tarigopula, G., Partha, P. & Peter, P., 2015.

Research output: Contribution to conferencePoster

Bleb formation is induced by alkaline but not acidic pH in estrogen receptor silenced breast cancer cells

Khajah, M. A., Mathew, P. M., Alam-Eldin, N. & Luqmani, Y. A., 1 Apr 2015, In : International Journal of Oncology. 46, 4, p. 1685-1698 14 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Causes of genome instability: The effect of low dose chemical exposures in modern society

Desaulniers, D., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Azqueta, A., Bisson, W. H., Brown, D., Brunborg, G., Charles, A. K., Chen, T., Colacci, A., Darroudi, F., Forte, S., Gonzalez, L., Hamid, R. A., Knudsen, L. E., Leyns, L., De Cerain Salsamendi, A. L., Memeo, L., Mondello, C. & 21 others, Mothersill, C., Olsen, A. K., Pavanello, S., Raju, J., Rojas, E., Roy, R., Ryan, E., Ostrosky-Wegman, P., Salem, H. K., Scovassi, I., Singh, N., Vaccari, M., Van Schooten, F. J., Valverde, M., Woodrick, J., Zhang, L., Van Larebeke, N., Kirsch-Volders, M., Collins, A. R., Langie, S. A. S. & Koppen, G., 1 Jun 2015, In : Carcinogenesis. 36, p. S61-S88

Research output: Contribution to journalReview article

Open Access
66 Citations (Scopus)

Chemical compounds from anthropogenic environment and immune evasion mechanisms: Potential interactions

Kravchenko, J., Corsini, E., Williams, M. A., Decker, W., Manjili, M. H., Otsuki, T., Singh, N., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Colacci, A. M., Vaccari, M., Mondello, C., Ivana Scovassi, A., Raju, J., Hamid, R. A., Memeo, L., Forte, S., Roy, R., Woodrick, J. & 6 others, Salem, H. K., Ryan, E. P., Brown, D. G., Bisson, W. H., Lowe, L. & Kim Lyerly, H., 1 Jun 2015, In : Carcinogenesis. 36, p. S111-S127

Research output: Contribution to journalReview article

Open Access
18 Citations (Scopus)

Dapagliflozin lowers plasma glucose concentration and improves β-cell function

Merovci, A., Mari, A., Solis, C., DeFronzo, R. A., Daniele, G., Chavez-Velazquez, A., Tripathy, D., McCarthy, S. U., Abdulghani, M. & Xiong, J., 1 May 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 5, p. 1927-1932 6 p.

Research output: Contribution to journalArticle

Open Access
72 Citations (Scopus)

Diabetes: A fast evolving epidemic

H M Ziyab, A., Mohammad, A., Maclean, E., Behbehani, K. & Carballo, M., 25 Nov 2015, In : Kuwait Medical Journal. 47, 4, p. 291-301 11 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Diabetic gastroparesis- a review of real-life clinical practice at a district general hospital in England

Aldibbiat, A. M., Nash, E., Sinclair, C., Partha, P., Peter, P. & Dar, A., 2015.

Research output: Contribution to conferencePaper

Disruptive chemicals, senescence and immortality

Carnero, A., Blanco-Aparicio, C., Kondoh, H., Lleonart, M. E., Martinez-Leal, J. F., Mondello, C., Scovassi, A. I., Bisson, W. H., Amedei, A., Roy, R., Woodrick, J., Colacci, A., Vaccari, M., Raju, J., Al-Mulla, F., Al-Temaimi, R., Salem, H. K., Memeo, L., Forte, S., Singh, N. & 6 others, Hamid, R. A., Ryan, E. P., Brown, D. G., Wise, J. P., Wise, S. S. & Yasaei, H., 1 Jan 2015, In : Carcinogenesis. 36, p. S19-S37

Research output: Contribution to journalReview article

Open Access
13 Citations (Scopus)

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Narayanan, K. B., Ali, M., Barclay, B. J., Cheng, Q., D'Abronzo, L., Dornetshuber-Fleiss, R., Ghosh, P. M., Gonzalez Guzman, M. J., Lee, T. J., Leung, P. S., Li, L., Luanpitpong, S., Ratovitski, E., Rojanasakul, Y., Romano, M. F., Romano, S., Sinha, R. K., Yedjou, C., Al-Mulla, F., Al-Temaimi, R. & 19 others, Amedei, A., Brown, D. G., Ryan, E. P., Colacci, A., Hamid, R. A., Mondello, C., Raju, J., Salem, H. K., Woodrick, J., Scovassi, I., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L., Kim, S. Y., Bisson, W. H., Lowe, L. & Park, H. H., 1 Jun 2015, In : Carcinogenesis. 36, p. S89-S110

Research output: Contribution to journalReview article

Open Access
20 Citations (Scopus)

Distribution of hepatitis C virus genotypes in bahrain

Janahi, E. M., Al-Mannai, M., Singh, H. & Jahromi, M., 7 Dec 2015, In : Hepatitis Monthly. 15, 12, e30300.

Research output: Contribution to journalArticle

7 Citations (Scopus)

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

Abu-Farha, M., Cherian, P., Al khairi, I., Tiss, A., Khadir, A., Kavalakatt, S., Warsame, S., Dehbi, M., Behbehani, K. & Abubaker, J., 24 Sep 2015, In : Scientific Reports. 5, 14448.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury

Jamal, M. H., Mohamed Ali Yaseen, H., Dashti, A., Al-Abbad, J., Dashti, H., Mathew, C., Al-Ali, W. & Asfar, S., 1 Jan 2015, In : International Journal of Clinical and Experimental Pathology. 8, 1, p. 649-654 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Empagliflozin and linagliptin combination therapy for treatment of patients with type 2 diabetes mellitus

Triplitt, C., Solis-Herrera, C., Cersosimo, E., Abdulghani, M. & Defronzo, R. A., 12 Dec 2015, In : Expert Opinion on Pharmacotherapy. 16, 18, p. 2819-2833 15 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Environmental immune disruptors, inflammation and cancer risk

Thompson, P. A., Khatami, M., Baglole, C. J., Sun, J., Harris, S. A., Moon, E. Y., Al-Mulla, F., Al-Temaimi, R., Brown, D. G., Colacci, A. M., Mondello, C., Raju, J., Ryan, E. P., Woodrick, J., Ivana Scovassi, A., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L. & 6 others, Salem, H. K., Amedei, A., Hamid, R. A., Lowe, L., Guarnieri, T. & Bisson, W. H., 1 Jan 2015, In : Carcinogenesis. 36, p. S232-S253

Research output: Contribution to journalReview article

Open Access
83 Citations (Scopus)

Familial hypercholesterolemia mutations in the Middle Eastern and North African region: A need for a national registry

Bamimore, M. A., Zaid, A., Banerjee, Y., AlSarraf, A., Abifadel, M., Seidah, N. G., Al-Waili, K., Al-Rasadi, K. & Awan, Z., 1 Mar 2015, In : Journal of Clinical Lipidology. 9, 2, p. 187-194 8 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Fiber orientation measurements by diffusion tensor imaging improve hydrogen-1 magnetic resonance spectroscopy of intramyocellular lipids in human leg muscles

Valaparla, S. K., Gao, F., Daniele, G., Abdulghani, M. & Clarke, G. D., 1 Apr 2015, In : Journal of Medical Imaging. 2, 2, 026002.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Gender influence in EBV antibody response in multiple sclerosis patients from Kuwait

Al-Temaimi, R., Alroughani, R., Jacob, S. & Al-Mulla, F., 1 Jan 2015, In : Journal of Neuroimmunology. 285, p. 57-61 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Gender-specific association of oxidative stress and inflammation with cardiovascular risk factors in Arab population

Khadir, A., Tiss, A., Kavalakatt, S., Behbehani, K., Dehbi, M. & Elkum, N., 1 Jan 2015, In : Mediators of Inflammation. 2015, 512603.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Genome-wide peripheral blood transcriptome analysis of Arab female lupus and lupus nephritis

AlFadhli, S., Ghanem, A. A. M. & Nizam, R., 10 Oct 2015, In : Gene. 570, 2, p. 230-238 9 p.

Research output: Contribution to journalArticle

Geographic distribution and adaptive significance of genomic structural variants: An anthropological genetics perspective

Eaaswarkhanth, M., Pavlidis, P. & Gokcumen, O., 1 Jan 2015, In : Human Biology. 86, 4, p. 260-275 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Global implementation of genomic medicine: We are not alone

Manolio, T. A., Abramowicz, M., Al-Mulla, F., Anderson, W., Balling, R., Berger, A. C., Bleyl, S., Chakravarti, A., Chantratita, W., Chisholm, R. L., Dissanayake, V. H. W., Dunn, M., Dzau, V. J., Han, B. G., Hubbard, T., Kolbe, A., Korf, B., Kubo, M., Lasko, P., Leego, E. & 24 others, Mahasirimongkol, S., Majumdar, P. P., Matthijs, G., McLeod, H. L., Metspalu, A., Meulien, P., Miyano, S., Naparstek, Y., O'Rourke, P. P., Patrinos, G. P., Rehm, H. L., Relling, M. V., Rennert, G., Rodriguez, L. L., Roden, D. M., Shuldiner, A. R., Sinha, S., Tan, P., Ulfendahl, M., Ward, R., Williams, M. S., Wong, J. E. L., Green, E. D. & Ginsburg, G. S., 3 Jun 2015, In : Science Translational Medicine. 7, 290, 290ps13.

Research output: Contribution to journalReview article

Open Access
86 Citations (Scopus)

High adiponectin levels in lean Arab women compared to Asian women

Abu-Farha, M., Behbehani, K. & Elkum, N., 2015, In : Biomarker Research. 3, p. 7 1 p.

Research output: Contribution to journalArticle

Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

Abu-Farha, M., Abubaker, J., Al khairi, I., Cherian, P., Noronha, F., Hu, F. B., Behbehani, K. & Elkum, N., 16 Jun 2015, In : Scientific Reports. 5, 10949.

Research output: Contribution to journalArticle

Open Access
72 Citations (Scopus)

High-spatial resolution multispectral and panchromatic satellite imagery for mapping perennial desert plants

Alsharrah, S., Bruce, D. A., Bouabid, R., Somenahalli, S. & Corcoran, P. A., 1 Jan 2015, Earth Resources and Environmental Remote Sensing/GIS Applications VI. Michel, U., Ehlers, M., Schulz, K., Nikolakopoulos, K. G. & Civco, D. (eds.). 96440Z. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 9644).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

HIV/AIDS: Dental assistants' self-reported knowledge and attitudes in Kuwait

Almuzaini, A. A. A. Y., Yahya, A. S. Y. S., Ellepola, A. N. B. & Sharma, P., 1 Apr 2015, In : International Dental Journal. 65, 2, p. 96-102 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Impact of brief exposure to antifungal agents on the post-antifungal effect and hemolysin activity of oral Candida albicans

Ellepola, A. N., Khajah, R., Jayatilake, S., Samaranayake, L., Sharma, P. & Khan, Z., 1 Jul 2015, In : Journal of Applied Oral Science. 23, 4, p. 412-418 7 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Implications of external price referencing of pharmaceuticals in Middle East countries

Kaló, Z., Alabbadi, I., Al Ahdab, O. G., Saadoun Abdulaziz Alowayesh, M., Elmahdawy, M., Al-Saggabi, A. H., Tanzi, V. L., Al-Badriyeh, D., Alsultan, H. S., Ali, F. M. H., Elsisi, G. H., Akhras, K. S., Vokó, Z. & Kanavos, P., 1 Nov 2015, In : Expert Review of Pharmacoeconomics and Outcomes Research. 15, 6, p. 993-998 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)