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2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: Focus on the cancer hallmark of tumor angiogenesis

Hu, Z., Brooks, S. A., Dormoy, V., Hsu, C. W., Hsu, H. Y., Lin, L. T., Massfelder, T., Kimryn Rathmell, W., Xia, M., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Brown, D. G., Prudhomme, K. R., Colacci, A., Hamid, R. A., Mondello, C., Raju, J., Ryan, E. P., Woodrick, J. & 11 others, Ivana Scovassi, A., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L., Salem, H. K., Lowe, L., Jensen, L., Bisson, W. H. & Kleinstreuer, N., 1 Jun 2015, In : Carcinogenesis. 36, p. S184-S202

Research output: Contribution to journal › Review article

Open Access
17 Citations (Scopus)

Association between body mass index and onset of hypertension in men and women with and without diabetes: A cross-sectional study using national health data from the State of Kuwait in the Arabian Peninsula

Channanath, A., Farran, B., Behbehani, K. & Thanaraj, A. T., 1 Jan 2015, In : BMJ Open. 5, 6, e007043.

Research output: Contribution to journal › Article

Open Access
9 Citations (Scopus)

Associations of TERC single nucleotide polymorphisms with human leukocyte telomere length and the risk of type 2 diabetes mellitus

Al Khaldi, R., Mojiminiyi, O., Al-Mulla, F. & Abdella, N., 1 Dec 2015, In : PloS one. 10, 12, e0145721.

Research output: Contribution to journal › Article

Open Access
9 Citations (Scopus)

A voxel-based morphometric magnetic resonance imaging study of the brain detects age-related gray matter volume changes in healthy subjects of 21-45 years old

KH H Bourisly, A., El-Beltagi, A., Cherian, J., Gejo, G., Al-Jazzaf, A. & Ismail, M., 1 Oct 2015, In : Neuroradiology Journal. 28, 5, p. 450-459 10 p.

Research output: Contribution to journal › Article

12 Citations (Scopus)

Balancing the benefits and risks of iron fortification in resource-constrained settings

Zlotkin, S. H., Davidsson, L. & Lozoff, B., 1 Oct 2015, In : Journal of Pediatrics. 167, 4, p. S26-S30

Research output: Contribution to journal › Article

2 Citations (Scopus)

Bariatric Surgery, with a surprise!.

Aldibbiat, A. M., Tarigopula, G., Partha, P. & Peter, P., 2015.

Research output: Contribution to conference › Poster

Bleb formation is induced by alkaline but not acidic pH in estrogen receptor silenced breast cancer cells

Khajah, M. A., Mathew, P. M., Alam-Eldin, N. & Luqmani, Y. A., 1 Apr 2015, In : International Journal of Oncology. 46, 4, p. 1685-1698 14 p.

Research output: Contribution to journal › Article

Open Access
14 Citations (Scopus)

Causes of genome instability: The effect of low dose chemical exposures in modern society

Desaulniers, D., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Azqueta, A., Bisson, W. H., Brown, D., Brunborg, G., Charles, A. K., Chen, T., Colacci, A., Darroudi, F., Forte, S., Gonzalez, L., Hamid, R. A., Knudsen, L. E., Leyns, L., De Cerain Salsamendi, A. L., Memeo, L., Mondello, C. & 21 others, Mothersill, C., Olsen, A. K., Pavanello, S., Raju, J., Rojas, E., Roy, R., Ryan, E., Ostrosky-Wegman, P., Salem, H. K., Scovassi, I., Singh, N., Vaccari, M., Van Schooten, F. J., Valverde, M., Woodrick, J., Zhang, L., Van Larebeke, N., Kirsch-Volders, M., Collins, A. R., Langie, S. A. S. & Koppen, G., 1 Jun 2015, In : Carcinogenesis. 36, p. S61-S88

Research output: Contribution to journal › Review article

Open Access
69 Citations (Scopus)

Changes in the Adipose Tissue Expression of CD86 Costimulatory Ligand and CD163 Scavenger Receptor in Obesity and Type-2 Diabetes: Implication for Metabolic Disease.

Sindhu, S., Thomas, R., Kochumon, S., Alshawaf, E., Hasan, A., Alghanim, M., Behbehani, K. & Ahmad, R., 2015, In : J Glycomics Lipidomics.

Research output: Contribution to journal › Article

Chemical compounds from anthropogenic environment and immune evasion mechanisms: Potential interactions

Kravchenko, J., Corsini, E., Williams, M. A., Decker, W., Manjili, M. H., Otsuki, T., Singh, N., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Colacci, A. M., Vaccari, M., Mondello, C., Ivana Scovassi, A., Raju, J., Hamid, R. A., Memeo, L., Forte, S., Roy, R., Woodrick, J. & 6 others, Salem, H. K., Ryan, E. P., Brown, D. G., Bisson, W. H., Lowe, L. & Kim Lyerly, H., 1 Jun 2015, In : Carcinogenesis. 36, p. S111-S127

Research output: Contribution to journal › Review article

Open Access
20 Citations (Scopus)

Dapagliflozin lowers plasma glucose concentration and improves β-cell function

Merovci, A., Mari, A., Solis, C., DeFronzo, R. A., Daniele, G., Chavez-Velazquez, A., Tripathy, D., McCarthy, S. U., Abdulghani, M. & Xiong, J., 1 May 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 5, p. 1927-1932 6 p.

Research output: Contribution to journal › Article

Open Access
75 Citations (Scopus)

Diabetes: A fast evolving epidemic

H M Ziyab, A., Mohammad, A., Maclean, E., Behbehani, K. & Carballo, M., 25 Nov 2015, In : Kuwait Medical Journal. 47, 4, p. 291-301 11 p.

Research output: Contribution to journal › Review article

5 Citations (Scopus)

Diabetic gastroparesis- a review of real-life clinical practice at a district general hospital in England

Aldibbiat, A. M., Nash, E., Sinclair, C., Partha, P., Peter, P. & Dar, A., 2015.

Research output: Contribution to conference › Paper

Disruptive chemicals, senescence and immortality

Carnero, A., Blanco-Aparicio, C., Kondoh, H., Lleonart, M. E., Martinez-Leal, J. F., Mondello, C., Scovassi, A. I., Bisson, W. H., Amedei, A., Roy, R., Woodrick, J., Colacci, A., Vaccari, M., Raju, J., Al-Mulla, F., Al-Temaimi, R., Salem, H. K., Memeo, L., Forte, S., Singh, N. & 6 others, Hamid, R. A., Ryan, E. P., Brown, D. G., Wise, J. P., Wise, S. S. & Yasaei, H., 1 Jan 2015, In : Carcinogenesis. 36, p. S19-S37

Research output: Contribution to journal › Review article

Open Access
15 Citations (Scopus)

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Narayanan, K. B., Ali, M., Barclay, B. J., Cheng, Q., D'Abronzo, L., Dornetshuber-Fleiss, R., Ghosh, P. M., Gonzalez Guzman, M. J., Lee, T. J., Leung, P. S., Li, L., Luanpitpong, S., Ratovitski, E., Rojanasakul, Y., Romano, M. F., Romano, S., Sinha, R. K., Yedjou, C., Al-Mulla, F., Al-Temaimi, R. & 19 others, Amedei, A., Brown, D. G., Ryan, E. P., Colacci, A., Hamid, R. A., Mondello, C., Raju, J., Salem, H. K., Woodrick, J., Scovassi, I., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L., Kim, S. Y., Bisson, W. H., Lowe, L. & Park, H. H., 1 Jun 2015, In : Carcinogenesis. 36, p. S89-S110

Research output: Contribution to journal › Review article

Open Access
20 Citations (Scopus)

Distribution of hepatitis C virus genotypes in bahrain

Janahi, E. M., Al-Mannai, M., Singh, H. & Jahromi, M., 7 Dec 2015, In : Hepatitis Monthly. 15, 12, e30300.

Research output: Contribution to journal › Article

8 Citations (Scopus)

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

Abu-Farha, M., Cherian, P., Al khairi, I., Tiss, A., Khadir, A., Kavalakatt, S., Warsame, S., Dehbi, M., Behbehani, K. & Abubaker, J., 24 Sep 2015, In : Scientific Reports. 5, 14448.

Research output: Contribution to journal › Article

Open Access
16 Citations (Scopus)

Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury

Jamal, M. H., Mohamed Ali Yaseen, H., Dashti, A., Al-Abbad, J., Dashti, H., Mathew, C., Al-Ali, W. & Asfar, S., 1 Jan 2015, In : International Journal of Clinical and Experimental Pathology. 8, 1, p. 649-654 6 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Empagliflozin and linagliptin combination therapy for treatment of patients with type 2 diabetes mellitus

Triplitt, C., Solis-Herrera, C., Cersosimo, E., Abdulghani, M. & Defronzo, R. A., 12 Dec 2015, In : Expert Opinion on Pharmacotherapy. 16, 18, p. 2819-2833 15 p.

Research output: Contribution to journal › Review article

14 Citations (Scopus)

Environmental immune disruptors, inflammation and cancer risk

Thompson, P. A., Khatami, M., Baglole, C. J., Sun, J., Harris, S. A., Moon, E. Y., Al-Mulla, F., Al-Temaimi, R., Brown, D. G., Colacci, A. M., Mondello, C., Raju, J., Ryan, E. P., Woodrick, J., Ivana Scovassi, A., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L. & 6 others, Salem, H. K., Amedei, A., Hamid, R. A., Lowe, L., Guarnieri, T. & Bisson, W. H., 1 Jan 2015, In : Carcinogenesis. 36, p. S232-S253

Research output: Contribution to journal › Review article

Open Access
88 Citations (Scopus)

Familial hypercholesterolemia mutations in the Middle Eastern and North African region: A need for a national registry

Bamimore, M. A., Zaid, A., Banerjee, Y., AlSarraf, A., Abifadel, M., Seidah, N. G., Al-Waili, K., Al-Rasadi, K. & Awan, Z., 1 Mar 2015, In : Journal of Clinical Lipidology. 9, 2, p. 187-194 8 p.

Research output: Contribution to journal › Review article

29 Citations (Scopus)

Fiber orientation measurements by diffusion tensor imaging improve hydrogen-1 magnetic resonance spectroscopy of intramyocellular lipids in human leg muscles

Valaparla, S. K., Gao, F., Daniele, G., Abdulghani, M. & Clarke, G. D., 1 Apr 2015, In : Journal of Medical Imaging. 2, 2, 026002.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Gender influence in EBV antibody response in multiple sclerosis patients from Kuwait

Al-Temaimi, R., Alroughani, R., Jacob, S. & Al-Mulla, F., 1 Jan 2015, In : Journal of Neuroimmunology. 285, p. 57-61 5 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Gender-specific association of oxidative stress and inflammation with cardiovascular risk factors in Arab population

Khadir, A., Tiss, A., Kavalakatt, S., Behbehani, K., Dehbi, M. & Elkum, N., 1 Jan 2015, In : Mediators of Inflammation. 2015, 512603.

Research output: Contribution to journal › Article

Open Access
9 Citations (Scopus)

Genome-wide peripheral blood transcriptome analysis of Arab female lupus and lupus nephritis

AlFadhli, S., Ghanem, A. A. M. & Nizam, R., 10 Oct 2015, In : Gene. 570, 2, p. 230-238 9 p.

Research output: Contribution to journal › Article

Geographic distribution and adaptive significance of genomic structural variants: An anthropological genetics perspective

Eaaswarkhanth, M., Pavlidis, P. & Gokcumen, O., 1 Jan 2015, In : Human Biology. 86, 4, p. 260-275 16 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Global implementation of genomic medicine: We are not alone

Manolio, T. A., Abramowicz, M., Al-Mulla, F., Anderson, W., Balling, R., Berger, A. C., Bleyl, S., Chakravarti, A., Chantratita, W., Chisholm, R. L., Dissanayake, V. H. W., Dunn, M., Dzau, V. J., Han, B. G., Hubbard, T., Kolbe, A., Korf, B., Kubo, M., Lasko, P., Leego, E. & 24 others, Mahasirimongkol, S., Majumdar, P. P., Matthijs, G., McLeod, H. L., Metspalu, A., Meulien, P., Miyano, S., Naparstek, Y., O'Rourke, P. P., Patrinos, G. P., Rehm, H. L., Relling, M. V., Rennert, G., Rodriguez, L. L., Roden, D. M., Shuldiner, A. R., Sinha, S., Tan, P., Ulfendahl, M., Ward, R., Williams, M. S., Wong, J. E. L., Green, E. D. & Ginsburg, G. S., 3 Jun 2015, In : Science Translational Medicine. 7, 290, 290ps13.

Research output: Contribution to journal › Review article

Open Access
88 Citations (Scopus)

High adiponectin levels in lean Arab women compared to Asian women

Abu-Farha, M., Behbehani, K. & Elkum, N., 2015, In : Biomarker Research. 3, p. 7 1 p.

Research output: Contribution to journal › Article

Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

Abu-Farha, M., Abubaker, J., Al khairi, I., Cherian, P., Noronha, F., Hu, F. B., Behbehani, K. & Elkum, N., 16 Jun 2015, In : Scientific Reports. 5, 10949.

Research output: Contribution to journal › Article

Open Access
73 Citations (Scopus)

High-spatial resolution multispectral and panchromatic satellite imagery for mapping perennial desert plants

Alsharrah, S., Bruce, D. A., Bouabid, R., Somenahalli, S. & Corcoran, P. A., 1 Jan 2015, Earth Resources and Environmental Remote Sensing/GIS Applications VI. Michel, U., Ehlers, M., Schulz, K., Nikolakopoulos, K. G. & Civco, D. (eds.). 96440Z. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 9644).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

HIV/AIDS: Dental assistants' self-reported knowledge and attitudes in Kuwait

Almuzaini, A. A. A. Y., Yahya, A. S. Y. S., Ellepola, A. N. B. & Sharma, P., 1 Apr 2015, In : International Dental Journal. 65, 2, p. 96-102 7 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Impact of brief exposure to antifungal agents on the post-antifungal effect and hemolysin activity of oral Candida albicans

Ellepola, A. N., Khajah, R., Jayatilake, S., Samaranayake, L., Sharma, P. & Khan, Z., 1 Jul 2015, In : Journal of Applied Oral Science. 23, 4, p. 412-418 7 p.

Research output: Contribution to journal › Article

Open Access
6 Citations (Scopus)

Implications of external price referencing of pharmaceuticals in Middle East countries

Kaló, Z., Alabbadi, I., Al Ahdab, O. G., Saadoun Abdulaziz Alowayesh, M., Elmahdawy, M., Al-Saggabi, A. H., Tanzi, V. L., Al-Badriyeh, D., Alsultan, H. S., Ali, F. M. H., Elsisi, G. H., Akhras, K. S., Vokó, Z. & Kanavos, P., 1 Nov 2015, In : Expert Review of Pharmacoeconomics and Outcomes Research. 15, 6, p. 993-998 6 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Increased adipose tissue expression toll like receptor (TLR)-7 in obese individual: Significance in metabolic disease

Sindhu, S., Wilson, A., Akhter, N., Shenouda, S., Kochumon, S., Ahmad, R. & Behbehani, K., 2015, In : J Glycomics Lipidomics. 5

Research output: Contribution to journal › Article

Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity

Ahmad, R., Kchumon, S., Thomas, R., Alghanim, M., Hasan, A., Sindhu, S. & Behbehani, K., 27 Aug 2015, In : Diabetology and Metabolic Syndrome. 7, 1, 71.

Research output: Contribution to journal › Article

Open Access
17 Citations (Scopus)

Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): A randomized trial

Abdulghani, M., Puckett, C., Triplitt, C., Maggs, D., Adams, J., Cersosimo, E. & Defronzo, R. A., 1 Mar 2015, In : Diabetes, Obesity and Metabolism. 17, 3, p. 268-275 8 p.

Research output: Contribution to journal › Article

84 Citations (Scopus)

Invasion is Promoted by Alkaline pH-induced Bleb Formation in Endocrine Resistant Breast Cancer Cells

Alam-Eldin, N., Feb 2015.

Research output: Contribution to conference › Poster

Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis

John, S. E., Thareja, G., Hebbar, P., Behbehani, K., Thanaraj, A. T. & Alsmadi, O., 1 Mar 2015, In : Genomics Data. 3, p. 116-127 12 p.

Research output: Contribution to journal › Article

Open Access
10 Citations (Scopus)

Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects

Abu-Farha, M., Abubaker, J., Noronha, F., Al khairi, I., Cherian, P., Alarouj, M., Bennakhi, A. & Elkum, N., 20 Aug 2015, In : Cardiovascular Diabetology. 14, 1, 112.

Research output: Contribution to journal › Article

Open Access
21 Citations (Scopus)

Map kinase phosphatase dusp1 is overexpressed in obese humans and modulated by physical exercise

Khadir, A., Tiss, A., Abubaker, J., Abu-Farha, M., Al khairi, I., Cherian, P., John, J., Kavalakatt, S., Warsame, S., Al Madhoun, A., Al-Ghimlas, F., Elkum, N., Behbehani, K., Dermime, S. & Dehbi, M., 1 Jan 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 1, p. E71-E83

Research output: Contribution to journal › Article

25 Citations (Scopus)

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Nahta, R., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Andrade-Vieira, R., Bay, S., Brown, D. G., Calaf, G. M., Castellino, R. C., Cohen-Solal, K. A., Colacci, A., Cruickshanks, N., Dent, P., Di Fiore, R., Forte, S., Goldberg, G. S., Hamid, R. A., Krishnan, H., Laird, D. W., Lasfar, A. & 18 others, Marignani, P. A., Memeo, L., Mondello, C., Naus, C. C., Ponce-Cusi, R., Raju, J., Roy, D., Roy, R., Ryan, E. P., Salem, H. K., Ivana Scovassi, A., Singh, N., Vaccari, M., Vento, R., Vondráček, J., Wade, M., Woodrick, J. & Bisson, W. H., 1 Jun 2015, In : Carcinogenesis. 36, p. S2-S18

Research output: Contribution to journal › Review article

Open Access
24 Citations (Scopus)

Metabolic reprogramming and dysregulated metabolism: Cause, consequence and/or enabler of environmental carcinogenesis?

Brooks Robey, R., Weisz, J., Kuemmerle, N., Salzberg, A. C., Berg, A., Brown, D. G., Kubik, L., Palorini, R., Al-Mulla, F., Al-Temaimi, R., Colacci, A., Mondello, C., Raju, J., Woodrick, J., Ivana Scovassi, A., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L. & 10 others, Salem, H. K., Amedei, A., Hamid, R. A., Williams, G. P., Lowe, L., Meyer, J., Martin, F. L., Bisson, W. H., Chiaradonna, F. & Ryan, E. P., 1 Jun 2015, In : Carcinogenesis. 36, p. S203-S231

Research output: Contribution to journal › Review article

Open Access
42 Citations (Scopus)

Multi-Lineage differentiation of human umbilical cord wharton's jelly mesenchymal stromal cells mediates changes in the expression profile of stemness markers

Mohamed Ali Yaseen, H., Al-Yatama, M. K., Abu-Farha, M., Behbehani, K. & Al Madhoun, A., 7 Apr 2015, In : PloS one. 10, 4, e0122465.

Research output: Contribution to journal › Article

Open Access
24 Citations (Scopus)

Multi-lineage differentiation of human umbilical cord Wharton’s jelly mesenchymal stromal cells mediates changes in the expression profile of stemness markers

Ali Yaseen, H. M., Al-Yatama, M. K., Abu-Farha, M., Behbehani, K. & Al Madhoun, A., 2015, In : PloS one. 10, 4, p. e0122465

Research output: Contribution to journal › Article

Multiprobabilistic prediction in early medical diagnoses

Nouretdinov, I., Devetyarov, D., Vovk, V., Burford, B., Camuzeaux, S., Gentry-Maharaj, A., Tiss, A., Smith, C., Luo, Z., Chervonenkis, A., Hallett, R., Waterfield, M., Cramer, R., Timms, J. F., Jacobs, I., Menon, U. & Gammerman, A., 8 Jun 2015, In : Annals of Mathematics and Artificial Intelligence. 74, 1-2, p. 203-222 20 p.

Research output: Contribution to journal › Article

8 Citations (Scopus)

Obesity is a positive modulator of IL-6R and IL-6 expression in the subcutaneous adipose tissue: Significance for metabolic inflammation

Sindhu, S., Thomas, R., Kchumon, S., Sriraman, D., Behbehani, K. & Ahmad, R., 22 Jul 2015, In : PloS one. 10, 7, e0133494.

Research output: Contribution to journal › Article

Open Access
78 Citations (Scopus)

Obesity Surgery and Ramadan: a Prospective Analysis of Nutritional Intake, Hunger and Satiety and Adaptive Behaviours During Fasting

Al Ozairi, E., Al Kandari, J., AlHaqqan, D., AlHarbi, O., Masters, Y. & Syed, A. A., 3 Mar 2015, In : Obesity Surgery. 25, 3, p. 523-529 7 p.

Research output: Contribution to journal › Article

4 Citations (Scopus)

Recombinant growth hormone therapy in children with short stature in Kuwait: A cross-sectional study of use and treatment outcomes

Mahmoud Yousef Alabdulrazzaq, D., Al-Taiar, A., Hassan, K. & Al-Basari, I., 3 Dec 2015, In : BMC Endocrine Disorders. 15, 1, 76.

Research output: Contribution to journal › Article

Open Access
3 Citations (Scopus)

Relationship of IL-5 with Th1 and Th2 Cytokines in Individuals with or without Type-2 Diabetes

Ahmad, R., Abu-AlRoub, A., Koshy, M., Sindhu, S. & Behbehani, K., 2015, In : J Glycomics Lipidomics. 5, 4, p. 1

Research output: Contribution to journal › Article

Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitus

Abdulghani, M., Norton, L. & Defronzo, R. A., 1 Jan 2015, In : American Journal of Physiology - Renal Physiology. 309, 11, p. F889-F900

Research output: Contribution to journal › Review article

61 Citations (Scopus)