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2015

Retinal nerve fiber layer thickness and neurologic disability in relapsing-remitting multiple sclerosis

Behbehani, R., Al-Hassan, A. A., Al-Khars, A., Sriraman, D. & Alroughani, R., 15 Dec 2015, In : Journal of the Neurological Sciences. 359, 1-2, p. 305-308 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

RKIP inhibits local breast cancer invasion by antagonizing the transcriptional activation of MMP13

Datar, I., Feng, J., Qiu, X., Lewandowski, J., Yeung, M., Ren, G., Aras, S., Al-Mulla, F., Cui, H., Trumbly, R., Arudra, S. K. C., De Las Casas, L. E., De La Serna, I., Sami Bitar, M. & Yeung, K. C., 26 Aug 2015, In : PloS one. 10, 8, e0134494.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration

Datar, I., Qiu, X., Ma, H. Z., Yeung, M., Aras, S., de la Serna, I., Al-Mulla, F., Thiery, J. P., Trumbly, R., Fan, X., Cui, H. & Yeung, K. C., 1 Jan 2015, In : Oncotarget. 6, 36, p. 39050-39061 12 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1

Hammad, M., Dunn, H. A., Walther, C. & Ferguson, S. S. G., 1 Oct 2015, In : Cellular Signalling. 27, 10, p. 2120-2130 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Sequence and analysis of a whole genome from Kuwaiti population subgroup of Persian ancestry

Thareja, G., John, S. E., Hebbar, P., Behbehani, K., Thanaraj, A. T. & Alsmadi, O., 12 Dec 2015, In : BMC Genomics. 16, 1, 92.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines1

Abbas, A., Hall, J. A., Patterson, W. L., Ho, E., Hsu, A., Al-Mulla, F. & Georgel, P. T., 9 Sep 2015, In : Biochemistry and Cell Biology. 94, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The aetiology of anaemia during pregnancy: A study to evaluate the contribution of iron deficiency and common infections in pregnant Ugandan women

Baingana, R. K., Enyaru, J. K., Tjalsma, H., Swinkels, D. W. & Davidsson, L., 1 Jan 2015, In : Public Health Nutrition. 18, 8, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The association of Vitamin D receptor polymorphisms with multiple sclerosis in a case-control study from Kuwait

Al-Temaimi, R. A., Al-Enezi, A., Al-Serri, A., Al-Roughani, R. & Al-Mulla, F., 5 Nov 2015, In : PloS one. 10, 11, e0142265.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

The Associations between Plasma Betatrophin Level and C-Peptide in Type 2 Diabetic and Nondiabetics

Abu-Farha, M., Abubaker, J., Al-Khairi, I., Cherian, P., Noronha, F., Al-Arouj, M., Behbehani, K., Bennakhi, A. & Elkum, N., 2015, DIABETES. Vol. 64. p. A733-A733

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The effect of environmental chemicals on the tumor microenvironment

Casey, S. C., Vaccari, M., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Barcellos-Hoff, M. H., Brown, D. G., Chapellier, M., Christopher, J., Curran, C., Forte, S., Hamid, R. A., Heneberg, P., Koch, D. C., Krishnakumar, P. K., Laconi, E., Maguer-Satta, V., Marongiu, F., Memeo, L., Mondello, C. & 15 others, Raju, J., Roman, J., Roy, R., Ryan, E. P., Ryeom, S., Salem, H. K., Ivana Scovassi, A., Singh, N., Soucek, L., Vermeulen, L., Whitfield, J. R., Woodrick, J., Colacci, A., Bisson, W. H. & Felsher, D. W., 1 Jun 2015, In : Carcinogenesis. 36, p. S160-S183

Research output: Contribution to journalReview article

Open Access
54 Citations (Scopus)

The Human Diabetes Proteome Project (HDPP): The 2014 update

Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D., Johnson, J. D., Konvalinka, A., Mulderm, H., Priego-Capote, F., Sechi, S., Snyder, M., Tiss, A., Wiederkehr, A. & 3 others, Xenarios, I., Kussmann, M. & Sanchez, J. C., 1 Dec 2015, In : Translational Proteomics. 8-9, p. 1-7 7 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

Ochieng, J., Nangami, G. N., Ogunkua, O., Miousse, I. R., Koturbash, I., Odero-Marah, V., McCawley, L., Nangia-Makker, P., Ahmed, N., Luqmani, Y., Chen, Z., Papagerakis, S., Wolf, G. T., Dong, C., Zhou, B. P., Brown, D. G., Colacci, A., Hamid, R. A., Mondello, C., Raju, J. & 14 others, Ryan, E. P., Woodrick, J., Scovassi, I., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L., Salem, H. K., Amedei, A., Al-Temaimi, R., Al-Mulla, F., Bisson, W. H. & Eltom, S. E., 1 Jun 2015, In : Carcinogenesis. 36, p. S128-S159

Research output: Contribution to journalReview article

Open Access
19 Citations (Scopus)

The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling

Engström, W., Darbre, P., Eriksson, S., Gulliver, L., Hultman, T., Karamouzis, M. V., Klaunig, J. E., Mehta, R., Moorwood, K., Sanderson, T., Sone, H., Vadgama, P., Wagemaker, G., Ward, A., Singh, N., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Colacci, A. M., Vaccari, M. & 12 others, Mondello, C., Ivana Scovassi, A., Raju, J., Hamid, R. A., Memeo, L., Forte, S., Roy, R., Woodrick, J., Salem, H. K., Ryan, E., Brown, D. G. & Bisson, W. H., 1 Jun 2015, In : Carcinogenesis. 36, p. S38-S60

Research output: Contribution to journalReview article

Open Access
20 Citations (Scopus)
Open Access
16 Citations (Scopus)

Total body water measurement using the 2H dilution technique for the assessment of body composition of Kuwaiti children

Al-Ati, T., Preston, T., Al-Hooti, S., Al-Hamad, N., Al-Ghanim, J., Al-Khulifi, F., Al-Lahou, B., Al-Othman, A. & Davidsson, L., 22 Jan 2015, In : Public Health Nutrition. 18, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Transcriptomic identification of adh1b as a novel candidate gene for obesity and insulin resistance in human adipose tissue in mexican americans from the veterans administration genetic epidemiology study (vages)

Winnier, D. A., Fourcaudot, M., Norton, L., Abdulghani, M., Hu, S. L., Farook, V. S., Coletta, D. K., Kumar, S., Puppala, S., Chittoor, G., Dyer, T. D., Arya, R., Carless, M., Lehman, D. M., Curran, J. E., Cromack, D. T., Tripathy, D., Blangero, J., Duggirala, R., Göring, H. H. H. & 2 others, DeFronzo, R. A. & Jenkinson, C. P., 1 Apr 2015, In : PloS one. 10, 4, 119941.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Trends in epithelial cell abnormalities observed on cervical smears over a 21-year period in atertiary care hospital in Kuwait

Kapila, K., Sharma, P., George, S. S., Al-Shaheen, A., Al-Juwaiser, A. & Al-Awadhi, R., 1 Jan 2015, In : Sultan Qaboos University Medical Journal. 15, 1, p. 112-115 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
6 Citations (Scopus)

Violating the Theory of Single Gene-Single Disorder: Inhibitor Development in Hemophilia

AlFadhli, S. & Nizam, R., 1 Jun 2015, In : Indian Journal of Hematology and Blood Transfusion. 31, 2, p. 162-168 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Where does combination therapy with an SGLT2 inhibitor plus a DPP-4 Inhibitor fit in the management of type 2 diabetes?

Abdulghani, M., 1 Mar 2015, In : Diabetes care. 38, 3, p. 373-375 3 p.

Research output: Contribution to journalComment/debate

Open Access
33 Citations (Scopus)
2014

Advanced medical students' experiences and views on professionalism at Kuwait University

Mahmoud Yousef Alabdulrazzaq, D., Al-Fadhli, A. & Arshad, A., 23 Jul 2014, In : BMC Medical Education. 14, 1, 150.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: Results from the Isle of Wight birth cohort

H M Ziyab, A., Karmaus, W., Zhang, H., Holloway, J. W., Steck, S. E., Ewart, S. & Arshad, S. H., 1 Jan 2014, In : Clinical and Experimental Allergy. 44, 9, p. 1170-1178 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor

Ryu, J., Galan, A. K., Xin, X., Dong, F., Abdulghani, M., Zhou, L., Wang, C., Li, C., Holmes, B. M., Sloane, L. B., Austad, S. N., Guo, S., Musi, N., DeFronzo, R. A., Deng, C., White, M. F., Liu, F. & Dong, L. Q., 22 May 2014, In : Cell Reports. 7, 4, p. 1227-1238 12 p.

Research output: Contribution to journalArticle

Open Access
62 Citations (Scopus)

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Thompson, B. A., Spurdle, A. B., Plazzer, J. P., Greenblatt, M. S., Akagi, K., Al-Mulla, F., Bapat, B., Bernstein, I., Capellá, G., Den Dunnen, J. T., Du Sart, D., Fabre, A., Farrell, M. P., Farrington, S. M., Frayling, I. M., Frebourg, T., Goldgar, D. E., Heinen, C. D., Holinski-Feder, E., Kohonen-Corish, M. & 119 others, Robinson, K. L., Leung, S. Y., Martins, A., Moller, P., Morak, M., Nystrom, M., Peltomaki, P., Pineda, M., Qi, M., Ramesar, R., Rasmussen, L. J., Royer-Pokora, B., Scott, R. J., Sijmons, R., Tavtigian, S. V., Tops, C. M., Weber, T., Wijnen, J., Woods, M. O., Macrae, F., Genuardi, M., Castillejo, A., Sexton, A., Chan, A. K. W., Viel, A., Blanco, A., French, A., Laner, A., Wagner, A., Van Den Ouweland, A., Mensenkamp, A., Payá, A., Betz, B., Redeker, B., Smith, B., Espenschied, C., Cummings, C., Engel, C., Fornes, C., Valenzuela, C., Alenda, C., Buchanan, D., Barana, D., Konstantinova, D., Cairns, D., Glaser, E., Silva, F., Lalloo, F., Crucianelli, F., Hogervorst, F., Casey, G., Tomlinson, I., Blanco, I., Villar, I. L., Garcia-Planells, J., Bigler, J., Shia, J., Martinez-Lopez, J., Gille, J. J. P., Hopper, J., Potter, J., Soto, J. L., Kantelinen, J., Ellis, K., Mann, K., Varesco, L., Zhang, L., Marchand, L. L., Marafie, M. J., Nordling, M., Tibiletti, M. G., Kahan, M. A., Ligtenberg, M., Clendenning, M., Jenkins, M., Speevak, M., Digweed, M., Kloor, M., Hitchins, M., Myers, M., Aronson, M., Valentin, M. D., Kutsche, M., Parsons, M., Walsh, M., Kansikas, M., Zahary, M. N., Pedroni, M., Heider, N., Poplawski, N., Rahner, N., Lindor, N. M., Sala, P., Nan, P., Propping, P., Newcomb, P., Sarin, R., Haile, R., Hofstra, R., Ward, R., Tricarico, R., Bacares, R., Young, S., Chialina, S., Kovalenko, S., Gunawardena, S. R., Moreno, S., Ho, S. L., Yuen, S. T., Thibodeau, S. N., Gallinger, S., Burnett, T., Teitsch, T., Chan, T. L., Smyrk, T., Cranston, T., Psofaki, V., Steinke-Lange, V. & Barbera, V. M., 1 Feb 2014, In : Nature Genetics. 46, 2, p. 107-115 9 p.

Research output: Contribution to journalReview article

269 Citations (Scopus)

Association of filaggrin variants with asthma and rhinitis: Is eczema or allergic sensitization status an effect modifier?

H M Ziyab, A., Karmaus, W., Zhang, H., Holloway, J. W., Steck, S. E., Ewart, S. & Arshad, S. H., 7 Nov 2014, In : International Archives of Allergy and Immunology. 164, 4, p. 308-318 11 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Autocalibration of accelerometer data for free-living physical activity assessment using local gravity and temperature: An evaluation on four continents

Van Hees, V. T., Fang, Z., Langford, J., Assah, F., Mohammad, A., Da Silva, I. C. M., Trenell, M. I., White, T., Wareham, N. J. & Brage, S., 1 Oct 2014, In : Journal of Applied Physiology. 117, 7, p. 738-744 7 p.

Research output: Contribution to journalArticle

Open Access
140 Citations (Scopus)

Bridging genomics research between developed and developing countries: The Genomic Medicine Alliance

Cooper, D. N., Brand, A., Dolzan, V., Fortina, P., Innocenti, F., Michael Lee, M. T., MacEk, M., Al-Mulla, F., Prainsack, B., Squassina, A., Vayena, E., Vozikis, A., Williams, M. S. & Patrinos, G. P., 1 Sep 2014, In : Personalized Medicine. 11, 7, p. 615-623 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Celiac disease in children: Is it a problem in Kuwait?

Al-Qabandi, W., Buhamrah, E., Mahmoud Yousef Alabdulrazzaq, D., Hamadi, K. & Al Refaee, F., 29 Dec 2014, In : Clinical and Experimental Gastroenterology. 8, p. 43-48 6 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals

Daniele, G., Eldor, R., Merovci, A., Clarke, G. D., Xiong, J., Tripathy, D., Taranova, A., Abdulghani, M. & DeFronzo, R. A., 1 Jan 2014, In : Diabetes. 63, 8, p. 2812-2820 9 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Circulating cell-free DNA in sickle cell disease: Is it a potentially useful biomarker?

Al-Humood, S., Zueriq, R., Al-Faris, L., Marouf, R. & Al-Mulla, F., 1 Jan 2014, In : Archives of Pathology and Laboratory Medicine. 138, 5, p. 678-683 6 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
Open Access
43 Citations (Scopus)

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production

Merovci, A., Solis-Herrera, C., Daniele, G., Eldor, R., Vanessa Fiorentino, T., Tripathy, D., Xiong, J., Perez, Z., Norton, L., Abdulghani, M. & DeFronzo, R. A., 3 Feb 2014, In : Journal of Clinical Investigation. 124, 2, p. 509-514 6 p.

Research output: Contribution to journalArticle

Open Access
429 Citations (Scopus)

De Novo Mutation Leading to Klinefelter-like Phenotype of Male Hypogonadism.

Aldibbiat, A. M., Peter, P., Partha, P. & Tarigopula, G., 2014.

Research output: Contribution to conferencePoster

Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences

H M Ziyab, A., Karmaus, W., Kurukulaaratchy, R. J., Zhang, H. & Arshad, S. H. A., 1 Oct 2014, In : Journal of Epidemiology and Community Health. 68, 10, p. 934-941 8 p.

Research output: Contribution to journalArticle

Open Access
74 Citations (Scopus)

Differential expression of alternative splice variants of CTLA4 in Kuwaiti autoimmune disease patients

AlFadhli, S. & Nizam, R., 25 Jan 2014, In : Gene. 534, 2, p. 307-312 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients

Cakirca, M., Karatoprak, C., Zorlu, M., Kiskac, M., Kanat, M., Cikrikcioglu, M. A., Soysal, P., Hursitoglu, M., Camli, A. A., Erkoc, R. & Abdulghani, M., 14 Feb 2014, In : Drug Design, Development and Therapy. 8, p. 239-243 5 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Electronic Sample Management Portal - National Dasman Diabetes Biobank at Dasman Diabetes Institute, Kuwait

Sriraman, D., Shyamsundar, A., Koshy, M., Lopez, V., Mathur, A., Chandy, B., Kochumon, S., Thomas, R., Ali, A. & Moorji, A. K., 2014.

Research output: Contribution to conferencePoster

Erratum: Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production (Journal of Clinical Investigation (2014) 124:2 (509-514) DOI:10.1172/JCI70704)

Merovci, A., Solis-Herrera, C., Daniele, G., Eldor, R., Fiorentino, T. V., Tripathy, D., Xiong, J., Perez, Z., Norton, L., Abdulghani, M. & DeFronzo, R. A., 1 Jan 2014, In : Journal of Clinical Investigation. 124, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Citation (Scopus)

Erratum to: Is Social Deprivation Associated with Weight Loss Outcomes Following Bariatric Surgery? A 10-Year Single Institutional Experience [OBES SURG, DOI 10.1007/s11695-014-1290-2]

Alfa Wali, M., Ashrafian, H., Schofield, K. L., Harling, L., Alkandari, A., Darzi, A., Athanasiou, T. & Efthimiou, E., 1 Jan 2014, In : Obesity Surgery. 24, 12, 1 p.

Research output: Contribution to journalComment/debate

Open Access

FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells

Ahmad, R., Kchumon, S., Jasem, S. & Behbehani, K., 12 Apr 2014, In : Cellular Physiology and Biochemistry. 34, 3, p. 929-942 14 p.

Research output: Contribution to journalArticle

Open Access
37 Citations (Scopus)

Gender-associated genomic differences in colorectal cancer: Clinical insight from feminization of male cancer cells

Ali, R. H., Marafie, M. J., Sami Bitar, M., Al-Dousari, F., Ismael, S., Haider, H. B., Al-Ali, W., Al-Mulla, F. & Jacob, S., 29 Sep 2014, In : International Journal of Molecular Sciences. 15, 10, p. 17344-17365 22 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Gender differences in ghrelin association with cardiometabolic risk factors in arab population

Abu-Farha, M., Dehbi, M., Noronha, F., Tiss, A., Alarouj, M., Behbehani, K., Bennakhi, A. & Elkum, N., 1 Jan 2014, In : International Journal of Endocrinology. 2014, 730472.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Genetic and epigenetic control of RKIP transcription

Datar, I., Tegegne, H., Qin, K., Al-Mulla, F., Sami Bitar, M., Trumbly, R. J. & Yeung, K. C., 1 Jan 2014, In : Critical Reviews in Oncogenesis. 19, 6, p. 417-430 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
22 Citations (Scopus)

Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development

Shalhout, S., Haddad, D., Sosin, A., Holland, T. C., Al-Katib, A., Martin, A. & Bhagwata, A. S., 1 Jan 2014, In : Molecular and Cellular Biology. 34, 21, p. 4019-4032 14 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Helicobacter pylori infection in pregnant women in four districts of Uganda: Role of geographic location, education and water sources

Baingana, R. K., Kiboko Enyaru, J. & Davidsson, L., 4 Sep 2014, In : BMC Public Health. 14, 1, 915.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects

Hasan, A., Al-Ghimlas, F., Warsame, S., Al-Hubail, A., Ahmad, R., Bennakhi, A., Al-Arouj, M., Behbehani, K., Dehbi, M. & Dermime, S., 10 May 2014, In : BMC Immunology. 15, 1, 19.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Immunogenetics of type 1 diabetes and its associated complications

Jahromi, M., 1 Jan 2014, Type 1 Diabetes: Causes, Treatment and Potential Complications. p. 69-101 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter