Activated human platelets express Fas-L and induce apoptosis in Fas-positive tumor cells

Rasheed Ahmad, José Menezes, Laurent Knafo, Ali Ahmad

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In addition to their role in hemostasis and thrombosis, platelets are important modulators of immune and inflammatory responses. We provide evidence here that human platelets contain abundant quantities of Fas-L, and upon activation, they express it on their surface as well as release it into medium. This surface-expressed Fas-L is biologically active and can induce apoptosis in Fas-positive human tumor cells. Therefore, activated platelets may represent an important player in Fas/Fas-L-mediated apoptosis.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Leukocyte Biology
Issue number1
Publication statusPublished - 5 Feb 2001



  • Apoptosis
  • Fas-L
  • Platelets
  • Thrombocytes
  • Tumor cells

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