Angiopoietin-like proteins in multiple sclerosis

Rabeah Al-Temaimi, Preethi Cherian, Mohamed Abu-Farha, Raed Alroughani

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Angiopoietin-like proteins (ANGPTLs) are a group of proteins with functions in lipid metabolism, angiogenesis, and inflammation. Here, we investigated their involvement in multiple sclerosis (MS) progression and response to treatment in 100 MS patients and 77 healthy controls. ANGPTLs significantly associated with MS progression and response to therapy. High ANGPTL6 levels associated with slow disease progression and good response to fingolimod treatment and low ANGPTL4 associated with poor response to natalizumab treatment. Therefore, we propose high ANGPTL4 and 6 levels as markers for positive response to MS treatments either natalizumab or fingolimod respectively. Further investigations into their role in MS is warranted.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalJournal of Neuroimmunology
Publication statusPublished - 15 May 2019


  • Angiopoietin-like proteins
  • Fingolimod
  • Multiple sclerosis
  • Natalizumab


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