Abstract
mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord. Accordingly, we examined the involvement of IGF-I in nociceptive transmission. An intrathecal injection of IGF-I (200-1000 ng) produced a dose-dependent elevation in nociceptive threshold as indicated by tail flick/withdrawal latency. In contrast, comparable doses of insulin had no significant effect. The time-response curve (15-75 min) revealed that the peak for IGF-I's antinociceptive effect is attained at 30 min. Our data provide evidence that the IGF-I system within the spinal cord may serve as a tar et for novel analgesics.
| Original language | English |
|---|---|
| Pages (from-to) | 292-294 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 737 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 21 Oct 1996 |
Keywords
- Insulin
- Insulin-like growth factor I
- Nociceptive transmission
- Spinal cord
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Sami Bitar, M., Al-Bustan, M., Nehme, C. L., & Pilcher, C. W. T. (1996). Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord. Brain Research, 737(1-2), 292-294. https://doi.org/10.1016/0006-8993(96)00747-0