Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord

Milad Sami Bitar; Mahmoud Al-Bustan; Cheryl L. Nehme; Charles W.T. Pilcher

doi:10.1016/0006-8993(96)00747-0

Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord

Milad Sami Bitar, Mahmoud Al-Bustan, Cheryl L. Nehme, Charles W.T. Pilcher

Genetics and Bioinformatics

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord. Accordingly, we examined the involvement of IGF-I in nociceptive transmission. An intrathecal injection of IGF-I (200-1000 ng) produced a dose-dependent elevation in nociceptive threshold as indicated by tail flick/withdrawal latency. In contrast, comparable doses of insulin had no significant effect. The time-response curve (15-75 min) revealed that the peak for IGF-I's antinociceptive effect is attained at 30 min. Our data provide evidence that the IGF-I system within the spinal cord may serve as a tar et for novel analgesics.

Original language	English
Pages (from-to)	292-294
Number of pages	3
Journal	Brain Research
Volume	737
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(96)00747-0
Publication status	Published - 21 Oct 1996

Keywords

Insulin
Insulin-like growth factor I
Nociceptive transmission
Spinal cord

Access to Document

10.1016/0006-8993(96)00747-0

Cite this

@article{3f626e0106bd4d559710cfcbb5d07813,

title = "Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord",

abstract = "mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord. Accordingly, we examined the involvement of IGF-I in nociceptive transmission. An intrathecal injection of IGF-I (200-1000 ng) produced a dose-dependent elevation in nociceptive threshold as indicated by tail flick/withdrawal latency. In contrast, comparable doses of insulin had no significant effect. The time-response curve (15-75 min) revealed that the peak for IGF-I's antinociceptive effect is attained at 30 min. Our data provide evidence that the IGF-I system within the spinal cord may serve as a tar et for novel analgesics.",

keywords = "Insulin, Insulin-like growth factor I, Nociceptive transmission, Spinal cord",

author = "{Sami Bitar}, Milad and Mahmoud Al-Bustan and Nehme, {Cheryl L.} and Pilcher, {Charles W.T.}",

year = "1996",

month = oct,

day = "21",

doi = "10.1016/0006-8993(96)00747-0",

language = "English",

volume = "737",

pages = "292--294",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord

AU - Sami Bitar, Milad

AU - Al-Bustan, Mahmoud

AU - Nehme, Cheryl L.

AU - Pilcher, Charles W.T.

PY - 1996/10/21

Y1 - 1996/10/21

N2 - mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord. Accordingly, we examined the involvement of IGF-I in nociceptive transmission. An intrathecal injection of IGF-I (200-1000 ng) produced a dose-dependent elevation in nociceptive threshold as indicated by tail flick/withdrawal latency. In contrast, comparable doses of insulin had no significant effect. The time-response curve (15-75 min) revealed that the peak for IGF-I's antinociceptive effect is attained at 30 min. Our data provide evidence that the IGF-I system within the spinal cord may serve as a tar et for novel analgesics.

AB - mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord. Accordingly, we examined the involvement of IGF-I in nociceptive transmission. An intrathecal injection of IGF-I (200-1000 ng) produced a dose-dependent elevation in nociceptive threshold as indicated by tail flick/withdrawal latency. In contrast, comparable doses of insulin had no significant effect. The time-response curve (15-75 min) revealed that the peak for IGF-I's antinociceptive effect is attained at 30 min. Our data provide evidence that the IGF-I system within the spinal cord may serve as a tar et for novel analgesics.

KW - Insulin

KW - Insulin-like growth factor I

KW - Nociceptive transmission

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0030597077&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(96)00747-0

DO - 10.1016/0006-8993(96)00747-0

M3 - Article

C2 - 8930378

AN - SCOPUS:0030597077

VL - 737

SP - 292

EP - 294

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -

Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this