Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord

Milad Sami Bitar, Mahmoud Al-Bustan, Cheryl L. Nehme, Charles W.T. Pilcher

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord. Accordingly, we examined the involvement of IGF-I in nociceptive transmission. An intrathecal injection of IGF-I (200-1000 ng) produced a dose-dependent elevation in nociceptive threshold as indicated by tail flick/withdrawal latency. In contrast, comparable doses of insulin had no significant effect. The time-response curve (15-75 min) revealed that the peak for IGF-I's antinociceptive effect is attained at 30 min. Our data provide evidence that the IGF-I system within the spinal cord may serve as a tar et for novel analgesics.

Original languageEnglish
Pages (from-to)292-294
Number of pages3
JournalBrain Research
Volume737
Issue number1-2
DOIs
Publication statusPublished - 21 Oct 1996

Keywords

  • Insulin
  • Insulin-like growth factor I
  • Nociceptive transmission
  • Spinal cord

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