ASD: The Alternative Splicing Database

Alphonse Thangavel Thanaraj, Stefan Stamm, Francis Clark, Jean Jack Riethoven, Vincent Le Texier, Juha Muilu

Research output: Contribution to journalArticlepeer-review

166 Citations (Scopus)

Abstract

Alternative splicing is widespread in mammalian gene expression, and variant splice patterns are often specific to different stages of development, particular tissues or a disease state. There is a need to systematically collect data on alternatively spliced exons, introns and splice isoforms, and to annotate this data. The Alternative Splicing Database consortium has been addressing this need, and is committed to maintaining and developing a value-added database of alternative splice events, and of experimentally verified regulatory mechanisms that mediate splice variants. In this paper we present two of the products from this project: namely, a database of computationally delineated alternative splice events as seen in alignments of EST/cDNA sequences with genome sequences, and a database of alternatively spliced exons collected from literature. The reported splice events are from nine different organisms and are annotated for various biological features including expression states and cross-species conservation. The data are presented on our ASD web pages (http://www.ebi.ac.uk/asd).

Original languageEnglish
JournalNucleic acids research
Volume32
Issue numberDATABASE ISS.
Publication statusPublished - 1 Jan 2004

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