Assessment of plasma biomarkers for their association with Multiple Sclerosis progression

Sindhu Jacob, Asmaa Al-Kandari, Raed Alroughani, Rabeah Al-Temaimi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In a cross-sectional study involving 160 Multiple Sclerosis (MS) patients and 70 healthy controls we set out to determine the association of five blood biomarkers with MS risk and progression scores. High levels of Semaphorin3A (SEMA3A) in females, and low levels of prolactin and estradiol in males associated with MS risk. High MS disability correlated with higher SEMA3A levels in females. Our findings suggest the clinical applicability of SEMA3A, and prolactin as biomarkers for MS progression. However, these biomarkers had sex-specific associations with MS, and any therapeutic approaches utilizing them should take that into consideration.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalJournal of Neuroimmunology
Volume305
DOIs
Publication statusPublished - 15 Apr 2017

Keywords

  • Multiple Sclerosis
  • Prolactin
  • Semaphorin3A
  • Sphingomyelin
  • Testosterone

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