Boronated thymidine analogues for boron neutron capture therapy

B. Thirumamagal, Jayaseharan Johnsamuel, Guirec Cosquer, Youngjoo Byun, Junhua Yan, Sureshbabu Narayanasamy, Werner Tjarks, Rolf Barth, Ashraf Al Madhoun, Staffan Eriksson

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Abstract

Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.

Original languageEnglish
Pages (from-to)861-866
Number of pages6
JournalNucleosides, Nucleotides and Nucleic Acids
Volume25
Issue number8
DOIs
Publication statusPublished - 1 Sep 2006

Keywords

  • 3-Carboranyl Thymidine Analogues (3CTAs)
  • Boron Neutron Capture Therapy (BNCT)

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    Thirumamagal, B., Johnsamuel, J., Cosquer, G., Byun, Y., Yan, J., Narayanasamy, S., Tjarks, W., Barth, R., Al Madhoun, A., & Eriksson, S. (2006). Boronated thymidine analogues for boron neutron capture therapy. Nucleosides, Nucleotides and Nucleic Acids, 25(8), 861-866. https://doi.org/10.1080/15257770600793844