Cellular and molecular pathogenesis of type 1A diabetes

Mohamed Jahromi, G. S. Eisenbarth

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Type 1A diabetes is an organ-specific autoimmune disease resulting from destruction of insulin-producing pancreatic β-cells. The main susceptibility genes code for polymorphic HLA molecules and in particular alleles of class II MHC genes (DR, DQ and DP). Polymorphisms of individual genes outside the MHC also contribute to diabetes risk but recent evidence suggests that there are additional non-HLA genes determining susceptibility linked to the MHC. It is now possible using genetic and autoantibody assays to predict the development of type 1A diabetes in the majority of individuals, and trials of diabetes prevention are underway.

Original languageEnglish
Pages (from-to)865-872
Number of pages8
JournalCellular and Molecular Life Sciences
Volume64
Issue number7-8
DOIs
Publication statusPublished - 1 Apr 2007

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Keywords

  • β-cell
  • Autoantibody
  • MHC
  • Oligogenic
  • Pathogenesis
  • Polyendocrinopathy
  • Polygenic
  • T1AD

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