Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells

Kazumichi Abe, Kim Phung Nguyen, Sean D. Fine, Ji Hun Mo, Carol Shen, Steve Shenouda, Maripat Corr, Steffen Jung, Jongdae Lee, Lars Eckmann, Eyal Raz

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte trafficking to the inflamed colon and restraining the inflammatory products of tissue macrophages. These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation.

Original languageEnglish
Pages (from-to)17022-17027
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number43
DOIs
Publication statusPublished - 23 Oct 2007

Keywords

  • Colitis
  • IFN-1
  • Toll-like receptor 9

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