Abstract
We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte trafficking to the inflamed colon and restraining the inflammatory products of tissue macrophages. These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 17022-17027 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 104 |
| Issue number | 43 |
| DOIs | |
| Publication status | Published - 23 Oct 2007 |
Keywords
- Colitis
- IFN-1
- Toll-like receptor 9
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Abe, K., Nguyen, K. P., Fine, S. D., Mo, J. H., Shen, C., Shenouda, S., Corr, M., Jung, S., Lee, J., Eckmann, L., & Raz, E. (2007). Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proceedings of the National Academy of Sciences of the United States of America, 104(43), 17022-17027. https://doi.org/10.1073/pnas.0708469104