Background Metabolic surgeries are by far one of the best available treatment options for a rapid improvement of obesity, the metabolic syndrome and its comorbidities as diabetes (T2D) and cardiovascular disease (CVD). Predictive markers of CVD have been employed to evaluate the improvement in CV health post-surgery Method: We compared baseline levels of; Atherogenic Index of Plasma (AIP), vascular age, circulating biochemical markers in two cohorts; normal weight and morbid-obese diabetic and non-diabetic people. Changes in these markers were further measured at various time points after laparoscopic sleeve gastrectomy, in the morbid-obese cohort. Results: At baseline, people with morbid-obesity and T2D had significantly higher AIP (0.227 ±0.06 Log TG/HDL, p <0.001), and oxidized low density lipoprotein (oxLDL) (1.67 ±0.17 µg/ml, p =0.007) compared to morbid-obesity alone (AIP = -0.083 ±0.06 Log TG/HDL, oxLDL = 0.96 ±0.09 µg/ml), and a significantly higher vascular age in people with morbid-obesity and T2D (65.8 ±3.7 year, p <0.0001) compared to morbid-obesity without T2D (37.9 ±2.6 year). Circulating biochemical markers such as; C-reactive protein, Von Willebrand Factor, D-dimer, Growth differentiation factor-15 and P-selectin were equally elevated at baseline in morbid-obese groups. A year post-surgery measurements showed a significant reduction in AIP = -0.135 ±0.07 Log TG/HDL, p =0.003, AIP = -0.36 ±0.04 Log TG/HDL, p =0.0002, morbid-obese with T2D and without T2D respectively. Conclusion: Results showed AIP as a better evaluating marker of CVD risk, as it makes the distinction between morbid-obesity and a combined morbid-obesity T2D setting. Although a number of circulating biochemical molecules have been established as predictive markers of CVD, our small-scale study involved patients who had T2D <5 years and no prior history of CVD, and in this cohort AIP served as a better evaluation marker for patients’ CVD risk pre- and post-surgery.
|Publication status||Published - 14 Nov 2018|
|Event||Obesity Week 2018 - Music city center, Nashville , United States|
Duration: 11 Nov 2018 → 15 Nov 2018
|Conference||Obesity Week 2018|
|Period||11/11/18 → 15/11/18|
- Bariatric surgery
- Type 2 diabetes mellitus
- Cardiovascular disease
Alshawaf, E., Al Ozairi, E., Al-Asfar, F., & Arefanian, H. (2018). CVD Risk Pre- and Post-metabolic surgery from an Atherogenic Index of Plasma perspective. Poster session presented at Obesity Week 2018, Nashville , United States.