Diabetes-induced changes in monoamine concentrations of rat hypothalamic nuclei

Milad Sami Bitar; Markku Koulu; Markku Linnoila

doi:10.1016/0006-8993(87)90707-4

Diabetes-induced changes in monoamine concentrations of rat hypothalamic nuclei

Milad Sami Bitar, Markku Koulu, Markku Linnoila

Genetics and Bioinformatics

Research output: Contribution to journal › Article

39 Citations (Scopus)

Abstract

Streptozotocin-induced diabetes produced marked alterations of monoamine concentrations in several hypothalamic nuclei of male and female rats. Norepinephrine (NE) concentrations were significantly elevated in the median eminence (ME), supraoptic nucleus (SON) and periventricular nucleus (PEVN) in both sexes of diabetic rats. NE concentrations in the suprachiasmatic nucleus (SCN) and ventromedial nucleus (VMN) of male and female diabetic animals remained unaltered. Serotonin (5-HT) concentrations were increased in PEVN of male and female diabetic rats. No significant changes in hypothalamic dopamine (DA) concentrations were observed. Insulin treatment reversed the diabetes-related changes in monoamine concentrations in most of the nuclei. The significance of these biochemical changes relative to the endocrine and behavioral abnormalities in diabetes is discussed.

Original language	English
Pages (from-to)	236-242
Number of pages	7
Journal	Brain Research
Volume	409
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90707-4
Publication status	Published - 21 Apr 1987

Keywords

Hypothalamic nucleus
Monoamine metabolism
Streptozotocin diabetes

Access to Document

10.1016/0006-8993(87)90707-4

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Diabetes-induced changes in monoamine concentrations of rat hypothalamic nuclei'. Together they form a unique fingerprint.

Cite this

@article{b1cc22b1f2084bb7a918314c1ce02a82,

title = "Diabetes-induced changes in monoamine concentrations of rat hypothalamic nuclei",

abstract = "Streptozotocin-induced diabetes produced marked alterations of monoamine concentrations in several hypothalamic nuclei of male and female rats. Norepinephrine (NE) concentrations were significantly elevated in the median eminence (ME), supraoptic nucleus (SON) and periventricular nucleus (PEVN) in both sexes of diabetic rats. NE concentrations in the suprachiasmatic nucleus (SCN) and ventromedial nucleus (VMN) of male and female diabetic animals remained unaltered. Serotonin (5-HT) concentrations were increased in PEVN of male and female diabetic rats. No significant changes in hypothalamic dopamine (DA) concentrations were observed. Insulin treatment reversed the diabetes-related changes in monoamine concentrations in most of the nuclei. The significance of these biochemical changes relative to the endocrine and behavioral abnormalities in diabetes is discussed.",

keywords = "Hypothalamic nucleus, Monoamine metabolism, Streptozotocin diabetes",

author = "{Sami Bitar}, Milad and Markku Koulu and Markku Linnoila",

year = "1987",

month = apr,

day = "21",

doi = "10.1016/0006-8993(87)90707-4",

language = "English",

volume = "409",

pages = "236--242",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Diabetes-induced changes in monoamine concentrations of rat hypothalamic nuclei

AU - Sami Bitar, Milad

AU - Koulu, Markku

AU - Linnoila, Markku

PY - 1987/4/21

Y1 - 1987/4/21

N2 - Streptozotocin-induced diabetes produced marked alterations of monoamine concentrations in several hypothalamic nuclei of male and female rats. Norepinephrine (NE) concentrations were significantly elevated in the median eminence (ME), supraoptic nucleus (SON) and periventricular nucleus (PEVN) in both sexes of diabetic rats. NE concentrations in the suprachiasmatic nucleus (SCN) and ventromedial nucleus (VMN) of male and female diabetic animals remained unaltered. Serotonin (5-HT) concentrations were increased in PEVN of male and female diabetic rats. No significant changes in hypothalamic dopamine (DA) concentrations were observed. Insulin treatment reversed the diabetes-related changes in monoamine concentrations in most of the nuclei. The significance of these biochemical changes relative to the endocrine and behavioral abnormalities in diabetes is discussed.

AB - Streptozotocin-induced diabetes produced marked alterations of monoamine concentrations in several hypothalamic nuclei of male and female rats. Norepinephrine (NE) concentrations were significantly elevated in the median eminence (ME), supraoptic nucleus (SON) and periventricular nucleus (PEVN) in both sexes of diabetic rats. NE concentrations in the suprachiasmatic nucleus (SCN) and ventromedial nucleus (VMN) of male and female diabetic animals remained unaltered. Serotonin (5-HT) concentrations were increased in PEVN of male and female diabetic rats. No significant changes in hypothalamic dopamine (DA) concentrations were observed. Insulin treatment reversed the diabetes-related changes in monoamine concentrations in most of the nuclei. The significance of these biochemical changes relative to the endocrine and behavioral abnormalities in diabetes is discussed.

KW - Hypothalamic nucleus

KW - Monoamine metabolism

KW - Streptozotocin diabetes

UR - http://www.scopus.com/inward/record.url?scp=0023274899&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(87)90707-4

DO - 10.1016/0006-8993(87)90707-4

M3 - Article

C2 - 2438007

AN - SCOPUS:0023274899

VL - 409

SP - 236

EP - 242

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -