Diabetes-related changes in brain beta adrenoreceptors in rats as assessed by quantitative autoradiography: Relationship to hypothalamic norepinephrine metabolism and pituitary-gonadal hormone secretion

Milad Sami Bitar, E. B. DeSouza

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22 Citations (Scopus)

Abstract

Streptozotocin (STZ)-induced diabetes produced significant and selective alterations in brain beta adrenoreceptor subtypes, norepinephrine (NE) metabolism and pituitary-testicular hormone in male rats. The densities of beta-1 but not beta-2 adrenoreceptors were increased in hypothalamus (anterior and lateral nuclei), thalamus (ventral posterior nucleus) and amygdala (basolateral nucleus) of the STZ diabetic rats. In contrast, a decrease in the rate of metabolism of NE (estimated by the concentration of the NE metabolite, 3-methoxy-4-hydroxyphenylglycol) was observed in these STZ-treated animals. Serum concentrations of luteinizing hormone and testosterone were lower in the STZ diabetic rats. Pretreatment of rats with nicotinamide prevented the induction of hyperglycemia, upregulation of brain beta-1 adrenoreceptors, decreases in NE metabolism and reduction in serum levels of luteinizing hormone and testosterone seen in STZ-treated rats. These data suggest that derangements in the hypothalamic-pituitary-testicular axis seen in uncontrolled diabetes may be secondary to decreases in NE metabolism and compensatory upregulation of beta-1 adrenoreceptors in brain.

Original languageEnglish
Pages (from-to)781-785
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume254
Issue number3
Publication statusPublished - 1 Jan 1990

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