Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes

Hussein Al-Jobori, Giuseppe Daniele, Eugenio Cersosimo, Curtis Triplitt, Rucha Mehta, Luke Norton, Ralph A. DeFronzo, Muhammad Abdulghani

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25 Citations (Scopus)

Abstract

Renal glucose reabsorption was measured with the stepped hyperglycemic clamp in 15 subjects with type 2 diabetes mellitus (T2DM) and 15 without diabetes after 2 days and after more chronic (14 days) treatment with empagliflozin. Patients with T2DM had significantly greater maximal renal glucose transport (TmG) compared with subjects without diabetes at baseline (459 ± 53 vs. 337 ± 25 mg/min; P < 0.05). Empagliflozin treatment for 48 h reduced the TmG in both individuals with and without diabetes by 44 ± 7 and 53 ± 6%, respectively (both P < 0.001). TmG was further reduced by empagliflozin in both groups on day 14 (by 65 ± 5 and 75 ± 3%, respectively). Empagliflozin reduced the plasma glucose concentration threshold for glucose spillage in the urine similarly in individuals with T2DM and without diabetes to <40 mg/dL, which is well below the normal fasting plasma glucose concentration. In summary, sodium-glucose transporter-2 inhibition with empagliflozin reduces both TmG and threshold for glucose spillage in the urine in patients with T2DM and those without diabetes.

Original languageEnglish
Pages (from-to)1999-2006
Number of pages8
JournalDiabetes
Volume66
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

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    Al-Jobori, H., Daniele, G., Cersosimo, E., Triplitt, C., Mehta, R., Norton, L., DeFronzo, R. A., & Abdulghani, M. (2017). Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes. Diabetes, 66(7), 1999-2006. https://doi.org/10.2337/db17-0100