Abstract
Using our gp120/41-expressing, NK cell activity-resistant CEM.NK R cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.
| Original language | English |
|---|---|
| Pages (from-to) | 227-233 |
| Number of pages | 7 |
| Journal | Journal of Clinical Immunology |
| Volume | 21 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jan 2001 |
Keywords
- AIDS
- Antibody-dependent cellular cytotoxicity
- CD4+ T cell counts
- HIV-1
- Plasma HIV load
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Ahmad, R., Sindhu, S., Toma, E., Morisset, R., Vincelette, J., Menezes, J., & Ahmad, A. (2001). Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection. Journal of Clinical Immunology, 21(3), 227-233. https://doi.org/10.1023/A:1011087132180