Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection

Rasheed Ahmad; Sardar Sindhu; Emil Toma; Richard Morisset; Jean Vincelette; Jose Menezes; Ali Ahmad

doi:10.1023/A:1011087132180

Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection

Rasheed Ahmad, Sardar Sindhu, Emil Toma, Richard Morisset, Jean Vincelette, Jose Menezes, Ali Ahmad

Immunology and Microbiology

Research output: Contribution to journal › Article › peer-review

120 Citations (Scopus)

Abstract

Using our gp120/41-expressing, NK cell activity-resistant CEM.NK ^R cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.

Original language	English
Pages (from-to)	227-233
Number of pages	7
Journal	Journal of Clinical Immunology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1023/A:1011087132180
Publication status	Published - 1 Jan 2001

Keywords

AIDS
Antibody-dependent cellular cytotoxicity
CD4+ T cell counts
HIV-1
Plasma HIV load

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10.1023/A:1011087132180

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title = "Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection",

abstract = " Using our gp120/41-expressing, NK cell activity-resistant CEM.NK R cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections. ",

keywords = "AIDS, Antibody-dependent cellular cytotoxicity, CD4+ T cell counts, HIV-1, Plasma HIV load",

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Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection. / Ahmad, Rasheed ; Sindhu, Sardar; Toma, Emil; Morisset, Richard; Vincelette, Jean; Menezes, Jose; Ahmad, Ali.

In: Journal of Clinical Immunology, Vol. 21, No. 3, 01.01.2001, p. 227-233.

Research output: Contribution to journal › Article › peer-review

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T1 - Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection

AU - Ahmad, Rasheed

AU - Sindhu, Sardar

AU - Toma, Emil

AU - Morisset, Richard

AU - Vincelette, Jean

AU - Menezes, Jose

AU - Ahmad, Ali

PY - 2001/1/1

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N2 - Using our gp120/41-expressing, NK cell activity-resistant CEM.NK R cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.

AB - Using our gp120/41-expressing, NK cell activity-resistant CEM.NK R cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.

KW - AIDS

KW - Antibody-dependent cellular cytotoxicity

KW - CD4+ T cell counts

KW - HIV-1

KW - Plasma HIV load

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Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection

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