Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection

Rasheed Ahmad, Sardar Sindhu, Emil Toma, Richard Morisset, Jean Vincelette, Jose Menezes, Ali Ahmad

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Using our gp120/41-expressing, NK cell activity-resistant CEM.NK R cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalJournal of Clinical Immunology
Volume21
Issue number3
DOIs
Publication statusPublished - 1 Jan 2001

Keywords

  • AIDS
  • Antibody-dependent cellular cytotoxicity
  • CD4+ T cell counts
  • HIV-1
  • Plasma HIV load

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