TY - JOUR
T1 - Fetuin-a expression profile in mouse and human adipose tissue
AU - Khadir, Abdelkrim
AU - Kavalakatt, Sina
AU - Madhu, Dhanya
AU - Tiss, Ali
PY - 2020/3/12
Y1 - 2020/3/12
N2 - Fetuin-A (Fet-A) was one of the first hepatokines to be reportedly linked to metabolic diseases. Fet-A was also suggested to be an adipokine, but its expression in the adipose tissue remains debatable. Here we compared the expression of Fet-A between human and mice adipose tissue biopsies as well as among human subcutaneous tissue and visceral adipose tissue primary cells, and mouse 3 T3-L1 cells at various stages of differentiation. Fet-A was expressed in mice biopsies and cells but not in human biopsies and cells, except in visceral adipose tissue primary cells following differentiation. Although the marginal expression of Fet-A in human visceral adipose tissue, a major contribution of Fet-A expression in human adipose tissue to systemic Fet-A levels is discounted, but it could indicate specific local Fet-A action in the visceral adipose tissue.
AB - Fetuin-A (Fet-A) was one of the first hepatokines to be reportedly linked to metabolic diseases. Fet-A was also suggested to be an adipokine, but its expression in the adipose tissue remains debatable. Here we compared the expression of Fet-A between human and mice adipose tissue biopsies as well as among human subcutaneous tissue and visceral adipose tissue primary cells, and mouse 3 T3-L1 cells at various stages of differentiation. Fet-A was expressed in mice biopsies and cells but not in human biopsies and cells, except in visceral adipose tissue primary cells following differentiation. Although the marginal expression of Fet-A in human visceral adipose tissue, a major contribution of Fet-A expression in human adipose tissue to systemic Fet-A levels is discounted, but it could indicate specific local Fet-A action in the visceral adipose tissue.
KW - Adipose tissue
KW - Fetuin-a
KW - Human adipose primary cells
KW - Mouse adipose tissue
UR - http://www.scopus.com/inward/record.url?scp=85081891946&partnerID=8YFLogxK
U2 - 10.1186/s12944-020-01225-7
DO - 10.1186/s12944-020-01225-7
M3 - Review article
C2 - 32164711
AN - SCOPUS:85081891946
VL - 19
JO - Lipids in Health and Disease
JF - Lipids in Health and Disease
SN - 1476-511X
IS - 1
M1 - 38
ER -