Fetuin-a expression profile in mouse and human adipose tissue

Research output: Contribution to journalReview article

Abstract

Fetuin-A (Fet-A) was one of the first hepatokines to be reportedly linked to metabolic diseases. Fet-A was also suggested to be an adipokine, but its expression in the adipose tissue remains debatable. Here we compared the expression of Fet-A between human and mice adipose tissue biopsies as well as among human subcutaneous tissue and visceral adipose tissue primary cells, and mouse 3 T3-L1 cells at various stages of differentiation. Fet-A was expressed in mice biopsies and cells but not in human biopsies and cells, except in visceral adipose tissue primary cells following differentiation. Although the marginal expression of Fet-A in human visceral adipose tissue, a major contribution of Fet-A expression in human adipose tissue to systemic Fet-A levels is discounted, but it could indicate specific local Fet-A action in the visceral adipose tissue.

Original languageEnglish
Article number38
JournalLipids in Health and Disease
Volume19
Issue number1
DOIs
Publication statusPublished - 12 Mar 2020

Keywords

  • Adipose tissue
  • Fetuin-a
  • Human adipose primary cells
  • Mouse adipose tissue

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