Genetic determinants of type 1 diabetes across populations

Mohamed Jahromi, George S. Eisenbarth

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

37 Citations (Scopus)


T1D results from autoimmune-mediated destruction of the pancreatic β cells, a process that is conditioned by multiple genes and environmental factors. The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. There are remarkable differences in genetic susceptibility to T1D between populations. We believe this variation reflects differing frequencies of diabetes causative and protective alleles and haplotypes, and thus remains a major genetic influence linked to the MHC region not accounted for by DR and DQ alleles. In this article, we discuss global variations in genetic susceptibility to T1D in view of current genetic understanding.

Original languageEnglish
Title of host publicationImmunology of Diabetes IV
Subtitle of host publicationProgress in Our Understanding
Number of pages11
Publication statusPublished - 1 Jan 2006

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • CTLA- 4
  • Insulin
  • PTPN 22
  • Type 1A diabetes


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