TY - GEN
T1 - Genetic determinants of type 1 diabetes across populations
AU - Jahromi, Mohamed
AU - Eisenbarth, George S.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - T1D results from autoimmune-mediated destruction of the pancreatic β cells, a process that is conditioned by multiple genes and environmental factors. The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. There are remarkable differences in genetic susceptibility to T1D between populations. We believe this variation reflects differing frequencies of diabetes causative and protective alleles and haplotypes, and thus remains a major genetic influence linked to the MHC region not accounted for by DR and DQ alleles. In this article, we discuss global variations in genetic susceptibility to T1D in view of current genetic understanding.
AB - T1D results from autoimmune-mediated destruction of the pancreatic β cells, a process that is conditioned by multiple genes and environmental factors. The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. There are remarkable differences in genetic susceptibility to T1D between populations. We believe this variation reflects differing frequencies of diabetes causative and protective alleles and haplotypes, and thus remains a major genetic influence linked to the MHC region not accounted for by DR and DQ alleles. In this article, we discuss global variations in genetic susceptibility to T1D in view of current genetic understanding.
KW - CTLA- 4
KW - Insulin
KW - PTPN 22
KW - Type 1A diabetes
UR - http://www.scopus.com/inward/record.url?scp=33845775174&partnerID=8YFLogxK
U2 - 10.1196/annals.1375.044
DO - 10.1196/annals.1375.044
M3 - Conference contribution
C2 - 17130568
AN - SCOPUS:33845775174
SN - 1573316415
SN - 9781573316415
T3 - Annals of the New York Academy of Sciences
SP - 289
EP - 299
BT - Immunology of Diabetes IV
ER -