Genetic determinants of type 1 diabetes across populations

Mohamed Jahromi, George S. Eisenbarth

Research output: Chapter in Book/Report/Conference proceedingConference contribution

36 Citations (Scopus)

Abstract

T1D results from autoimmune-mediated destruction of the pancreatic β cells, a process that is conditioned by multiple genes and environmental factors. The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. There are remarkable differences in genetic susceptibility to T1D between populations. We believe this variation reflects differing frequencies of diabetes causative and protective alleles and haplotypes, and thus remains a major genetic influence linked to the MHC region not accounted for by DR and DQ alleles. In this article, we discuss global variations in genetic susceptibility to T1D in view of current genetic understanding.

Original languageEnglish
Title of host publicationImmunology of Diabetes IV
Subtitle of host publicationProgress in Our Understanding
Pages289-299
Number of pages11
DOIs
Publication statusPublished - 1 Jan 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1079
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • CTLA- 4
  • Insulin
  • PTPN 22
  • Type 1A diabetes

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    Jahromi, M., & Eisenbarth, G. S. (2006). Genetic determinants of type 1 diabetes across populations. In Immunology of Diabetes IV: Progress in Our Understanding (pp. 289-299). (Annals of the New York Academy of Sciences; Vol. 1079). https://doi.org/10.1196/annals.1375.044