Genetic variants associated with warfarin dosage in Kuwaiti population

Sumi Elsa John, Dinu Antony, Muthukrishnan Eaaswarkhanth, Prashantha Hebbar, Fadi Alkayal, Jaakko Tuomilehto, Osama Alsmadi, Alphonse Thangavel Thanaraj

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different population groups is actively pursued by pharmacogenomics community. Populations from Arabian Peninsula are underrepresented in such studies. By way of examining exome- and genome-wide genotype data from 1395 Arab individuals in Kuwait, we report distinct occurrence of warfarin response-related variants rs12460590-A/CYP2A7, rs2108622-T/CYP4F2, rs2884737-C/VKORC1 and distinct absence of rs11150606-C/PRSS53 in Kuwaiti population. The presented results in conjunction with similar literature reports on Qatari population enhance the worldwide understanding on population-specific distributions of genetic variants associated with warfarin drug dosage.

Original languageEnglish
JournalPharmacogenomics
Volume18
Issue number8
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • anticoagulation
  • Arab population
  • CYP2A7
  • CYP4F2
  • exome
  • genetic variants
  • Kuwait
  • PRSS53
  • VKORC1
  • warfarin

Fingerprint Dive into the research topics of 'Genetic variants associated with warfarin dosage in Kuwaiti population'. Together they form a unique fingerprint.

  • Cite this