Genetic variants associated with warfarin dosage in Kuwaiti population

Sumi Elsa John; Dinu Antony; Muthukrishnan Eaaswarkhanth; Prashantha Hebbar; Fadi Alkayal; Jaakko Tuomilehto; Osama Alsmadi; Alphonse Thangavel Thanaraj

doi:10.2217/pgs-2017-0020

Genetic variants associated with warfarin dosage in Kuwaiti population

Sumi Elsa John, Dinu Antony, Muthukrishnan Eaaswarkhanth, Prashantha Hebbar, Fadi Alkayal, Jaakko Tuomilehto, Osama Alsmadi, Alphonse Thangavel Thanaraj

Genetics and Bioinformatics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different population groups is actively pursued by pharmacogenomics community. Populations from Arabian Peninsula are underrepresented in such studies. By way of examining exome- and genome-wide genotype data from 1395 Arab individuals in Kuwait, we report distinct occurrence of warfarin response-related variants rs12460590-A/CYP2A7, rs2108622-T/CYP4F2, rs2884737-C/VKORC1 and distinct absence of rs11150606-C/PRSS53 in Kuwaiti population. The presented results in conjunction with similar literature reports on Qatari population enhance the worldwide understanding on population-specific distributions of genetic variants associated with warfarin drug dosage.

Original language	English
Journal	Pharmacogenomics
Volume	18
Issue number	8
DOIs	https://doi.org/10.2217/pgs-2017-0020
Publication status	Published - 1 Jun 2017

Keywords

anticoagulation
Arab population
CYP2A7
CYP4F2
exome
genetic variants
Kuwait
PRSS53
VKORC1
warfarin

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title = "Genetic variants associated with warfarin dosage in Kuwaiti population",

abstract = "Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different population groups is actively pursued by pharmacogenomics community. Populations from Arabian Peninsula are underrepresented in such studies. By way of examining exome- and genome-wide genotype data from 1395 Arab individuals in Kuwait, we report distinct occurrence of warfarin response-related variants rs12460590-A/CYP2A7, rs2108622-T/CYP4F2, rs2884737-C/VKORC1 and distinct absence of rs11150606-C/PRSS53 in Kuwaiti population. The presented results in conjunction with similar literature reports on Qatari population enhance the worldwide understanding on population-specific distributions of genetic variants associated with warfarin drug dosage.",

keywords = "anticoagulation, Arab population, CYP2A7, CYP4F2, exome, genetic variants, Kuwait, PRSS53, VKORC1, warfarin",

author = "John, {Sumi Elsa} and Dinu Antony and Muthukrishnan Eaaswarkhanth and Prashantha Hebbar and Fadi Alkayal and Jaakko Tuomilehto and Osama Alsmadi and Thanaraj, {Alphonse Thangavel}",

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AU - John, Sumi Elsa

AU - Antony, Dinu

AU - Eaaswarkhanth, Muthukrishnan

AU - Hebbar, Prashantha

AU - Alkayal, Fadi

AU - Tuomilehto, Jaakko

AU - Alsmadi, Osama

AU - Thanaraj, Alphonse Thangavel

PY - 2017/6/1

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KW - anticoagulation

KW - Arab population

KW - CYP2A7

KW - CYP4F2

KW - exome

KW - genetic variants

KW - Kuwait

KW - PRSS53

KW - VKORC1

KW - warfarin

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