Glycolaldehyde induces apoptosis in a human breast cancer cell line

May A. Al-Maghrebi, Fahd Al-Mulla, Ludmil T. Benov

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Activated phagocytes employ myeloperoxidase to generate glycolaldehyde, 2-hydroxypropanal, and acrolein. Because α-hydroxy and α,β-unsaturated aldehydes are highly reactive, phagocyte-mediated formation of these products may play a role in killing bacteria and tumor cells. Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalArchives of Biochemistry and Biophysics
Volume417
Issue number1
DOIs
Publication statusPublished - 1 Sep 2003

Keywords

  • Anti-tumor activity of glycolaldehyde
  • Apoptosis
  • Breast cancer
  • Glycolaldehyde
  • Superoxide dismutase

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