Abstract
Activated phagocytes employ myeloperoxidase to generate glycolaldehyde, 2-hydroxypropanal, and acrolein. Because α-hydroxy and α,β-unsaturated aldehydes are highly reactive, phagocyte-mediated formation of these products may play a role in killing bacteria and tumor cells. Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity.
| Original language | English |
|---|---|
| Pages (from-to) | 123-127 |
| Number of pages | 5 |
| Journal | Archives of Biochemistry and Biophysics |
| Volume | 417 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Sep 2003 |
Keywords
- Anti-tumor activity of glycolaldehyde
- Apoptosis
- Breast cancer
- Glycolaldehyde
- Superoxide dismutase
Fingerprint Dive into the research topics of 'Glycolaldehyde induces apoptosis in a human breast cancer cell line'. Together they form a unique fingerprint.
Cite this
Al-Maghrebi, M. A., Al-Mulla, F., & Benov, L. T. (2003). Glycolaldehyde induces apoptosis in a human breast cancer cell line. Archives of Biochemistry and Biophysics, 417(1), 123-127. https://doi.org/10.1016/S0003-9861(03)00334-5