Impairment of albuterol-induced suppression of food intake in diabetes mellitus

Milad Sami Bitar, Adelbert F. Keis, Stephen E. Owusu, Ronnie Mulven, Errol B. Desouza

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Albuterol (salbutamol), a β2 adrenoreceptor agonist, produced a dose-dependent decrease in food intake in Sprague-Dawley male control rats. This phenomenon appeared to be impaired in streptozotocin (STZ) diabetic rats. The density of β2 adrenoreceptors in the ventromedial hypothalamic nucleus was increased as a function of diabetes. In contrast, a decrease in the ventromedial hypothalamic 5-hydroxyindoleacetic acid (5-HIAA) concentration, an indicator of serotonin (5-hydroxytryptamine; 5-HT) release or turnover rate, was observed in this disease state. Neither the β2 adrenoreceptors level nor 5-HT turnover rate was altered in the periventricular hypothalamic nucleus of STZ diabetic rats. The concentrations of 5-HT in both hypothalamic nuclei were unchanged in these animals. Neurochemical and behavioral abnormalities featured in the diabetic state were reversed with institution of insulin therapy. These data conclude that diabetes-related impairment in the anorexic action of albuterol may be due to derangements in ventromedial hypothalamic β2 adrenoceptor function.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume41
Issue number3
DOIs
Publication statusPublished - 1 Jan 1992

Keywords

  • Albuterol
  • Diabetes
  • Ingestive behavior
  • β adrenoreceptors

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