Intrinsic and extrinsic labeling for studies of manganese absorption in humans

Lena Davidsson, A. Cederblad, E. Hagebo, B. Lonnerdal, B. Sandstrom

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


A dual-radioisotope method was used to simultaneously study whole-body manganese retention from a chicken liver based meal intrinsically labeled with 54Mn and extrinsically labeled with 52Mn. Manganese retention was monitored in a sensitive whole-body counter during approximately 30 d in six young adult women. Both radioisotopes were retained to a similar degree and excreted at identical rates. Retention at d 5 was 14.4 ± 10.3 and 14.0 ± 9.9% while retention at d 10 was 5.0 ± 3.1 and 5.0 ± 3.0% (X̄ ± SD) for 54Mn and 52Mn, respectively. From these results we conclude that the intrinsic and extrinsic Mn isotopes did form a common pool before absorption. The results can therefore be regarded as a direct validation of the use of extrinsic labeling for studies of Mn retention for estimating Mn absorption in man.

Original languageEnglish
Pages (from-to)1517-1521
Number of pages5
JournalJournal of Nutrition
Issue number12
Publication statusPublished - 1 Jan 1988


Dive into the research topics of 'Intrinsic and extrinsic labeling for studies of manganese absorption in humans'. Together they form a unique fingerprint.

Cite this