TY - JOUR
T1 - Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis
AU - John, Sumi Elsa
AU - Thareja, Gaurav
AU - Hebbar, Prashantha
AU - Behbehani, Kazem
AU - Thanaraj, Alphonse Thangavel
AU - Alsmadi, Osama
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Kuwaiti native population comprises three distinct genetic subgroups of Persian, "city-dwelling" Saudi Arabian tribe, and nomadic "tent-dwelling" Bedouin ancestry. Bedouin subgroup is characterized by presence of 17% African ancestry; it owes it origin to nomadic tribes of the deserts of Arabian Peninsula and North Africa. By sequencing whole genome of a Kuwaiti male from this subgroup at 41X coverage, we report 3,752,878 SNPs, 411,839 indels, and 8451 structural variations. Neighbor-joining tree, based on shared variant positions carrying disease-risk alleles between the Bedouin and other continental genomes, places Bedouin genome at the nexus of African, Asian, and European genomes in concordance with geographical location of Kuwait and Peninsula. In congruence with participant's medical history for morbid obesity and bronchial asthma, risk alleles are seen at deleterious SNPs associated with obesity and asthma. Many of the observed deleterious 'novel' variants lie in genes associated with autosomal recessive disorders characteristic of the region.
AB - Kuwaiti native population comprises three distinct genetic subgroups of Persian, "city-dwelling" Saudi Arabian tribe, and nomadic "tent-dwelling" Bedouin ancestry. Bedouin subgroup is characterized by presence of 17% African ancestry; it owes it origin to nomadic tribes of the deserts of Arabian Peninsula and North Africa. By sequencing whole genome of a Kuwaiti male from this subgroup at 41X coverage, we report 3,752,878 SNPs, 411,839 indels, and 8451 structural variations. Neighbor-joining tree, based on shared variant positions carrying disease-risk alleles between the Bedouin and other continental genomes, places Bedouin genome at the nexus of African, Asian, and European genomes in concordance with geographical location of Kuwait and Peninsula. In congruence with participant's medical history for morbid obesity and bronchial asthma, risk alleles are seen at deleterious SNPs associated with obesity and asthma. Many of the observed deleterious 'novel' variants lie in genes associated with autosomal recessive disorders characteristic of the region.
KW - "Tent-dwelling" Bedouins
KW - Arabian Peninsula
KW - Intergenome distances
KW - Kuwaiti population
KW - Nomadic Bedouin ancestry
KW - Whole genome sequence
UR - http://www.scopus.com/inward/record.url?scp=84922942901&partnerID=8YFLogxK
U2 - 10.1016/j.gdata.2014.11.016
DO - 10.1016/j.gdata.2014.11.016
M3 - Article
AN - SCOPUS:84922942901
VL - 3
SP - 116
EP - 127
JO - Genomics Data
JF - Genomics Data
SN - 2213-5960
ER -