Abstract
Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present the clinical, immunologic and molecular features of 11 Kuwaiti patients who presented with MHC class II deficiency between 2004 and 2011.
Original language | English |
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Pages (from-to) | 513-519 |
Number of pages | 7 |
Journal | Journal of Clinical Immunology |
Volume | 33 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Apr 2013 |
Keywords
- Consanguinity
- Kuwait
- MHC class II deficiency
- Molecular diagnosis
- RFXANK gene