Major histocompatibility complex class II deficiency in Kuwait: Clinical manifestations, immunological findings and molecular profile

Waleed Al-Herz, Osama Alsmadi, Motasem  Melhem, Mike Recher, Francesco Frugoni, Luigi D. Notarangelo

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present the clinical, immunologic and molecular features of 11 Kuwaiti patients who presented with MHC class II deficiency between 2004 and 2011.

Original languageEnglish
Pages (from-to)513-519
Number of pages7
JournalJournal of Clinical Immunology
Volume33
Issue number3
DOIs
Publication statusPublished - 1 Apr 2013

Keywords

  • Consanguinity
  • Kuwait
  • MHC class II deficiency
  • Molecular diagnosis
  • RFXANK gene

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