Major histocompatibility complex class II deficiency in Kuwait: Clinical manifestations, immunological findings and molecular profile

Waleed Al-Herz; Osama Alsmadi; Motasem  Melhem; Mike Recher; Francesco Frugoni; Luigi D. Notarangelo

doi:10.1007/s10875-012-9831-8

Major histocompatibility complex class II deficiency in Kuwait: Clinical manifestations, immunological findings and molecular profile

Waleed Al-Herz, Osama Alsmadi, Motasem Melhem, Mike Recher, Francesco Frugoni, Luigi D. Notarangelo

Genetics and Bioinformatics

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present the clinical, immunologic and molecular features of 11 Kuwaiti patients who presented with MHC class II deficiency between 2004 and 2011.

Original language	English
Pages (from-to)	513-519
Number of pages	7
Journal	Journal of Clinical Immunology
Volume	33
Issue number	3
DOIs	https://doi.org/10.1007/s10875-012-9831-8
Publication status	Published - 1 Apr 2013

Keywords

Consanguinity
Kuwait
MHC class II deficiency
Molecular diagnosis
RFXANK gene

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Major histocompatibility complex class II deficiency in Kuwait : Clinical manifestations, immunological findings and molecular profile. / Al-Herz, Waleed; Alsmadi, Osama; Melhem, Motasem ; Recher, Mike; Frugoni, Francesco; Notarangelo, Luigi D.

In: Journal of Clinical Immunology, Vol. 33, No. 3, 01.04.2013, p. 513-519.

Research output: Contribution to journal › Article › peer-review

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AU - Recher, Mike

AU - Frugoni, Francesco

AU - Notarangelo, Luigi D.

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Major histocompatibility complex class II deficiency in Kuwait: Clinical manifestations, immunological findings and molecular profile

Abstract

Keywords

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