Mass spectrometry in clinical proteomics - From the present to the future

Magnus Palmblad, Ali Tiss, Rainer Cramer

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)


MS is an important analytical tool in clinical proteomics, primarily in the disease-specific discovery, identification and characterisation of proteomic biomarkers and patterns. MS-based proteomics is increasingly used in clinical validation and diagnostic method development. The latter departs from the typical application of MS-based proteomics by exchanging some of the high performance of analysis for the throughput, robustness and simplicity required for clinical diagnostics. Although conventional MS-based proteomics has become an important field in clinical applications, some of the most recent MS technologies have not yet been extensively applied in clinical proteomics. In this review, we will describe the current state of MS in clinical proteomics and look to the future of this field.

Original languageEnglish
Pages (from-to)6-17
Number of pages12
JournalProteomics - Clinical Applications
Issue number1
Publication statusPublished - 14 May 2009


  • Clinical proteomics
  • Diagnostics
  • Mass spectrometry
  • Profiling
  • Screening


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