Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Rita Nahta, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Rafaela Andrade-Vieira, Sarah Bay, Dustin G. Brown, Gloria M. Calaf, Robert C. Castellino, Karine A. Cohen-Solal, Annamaria Colacci, Nichola Cruickshanks, Paul Dent, Riccardo Di Fiore, Stefano Forte, Gary S. Goldberg, Roslida A. Hamid, Harini Krishnan, Dale W. Laird, Ahmed LasfarPaola A. Marignani, Lorenzo Memeo, Chiara Mondello, Christian C. Naus, Richard Ponce-Cusi, Jayadev Raju, Debasish Roy, Rabindra Roy, Elizabeth P. Ryan, Hosni K. Salem, A. Ivana Scovassi, Neetu Singh, Monica Vaccari, Renza Vento, Jan Vondráček, Mark Wade, Jordan Woodrick, William H. Bisson

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

Original languageEnglish
Pages (from-to)S2-S18
JournalCarcinogenesis
Volume36
DOIs
Publication statusPublished - 1 Jun 2015

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