Optimization of low-level light therapy's illumination parameters for spinal cord injury in a rat model

Ali Shuaib, Ali KH H Bourisly

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Spinal cord injury (SCI) can result in complete or partial loss of sensation and motor function due to interruption along the severed axonal tract(s). SCI can result in tetraplegia or paraplegia, which can have prohibitive lifetime medical costs and result in shorter life expectancy. A promising therapeutic technique that is currently in experimental phase and that has the potential to be used to treat SCI is Low-level light therapy (LLLT). Preclinical studies have shown that LLLT has reparative and regenerative capabilities on transected spinal cords, and that LLLT can enhance axonal sprouting in animal models. However, despite the promising effects of LLLT as a therapy for SCI, it remains difficult to compare published results due to the use of a wide range of illumination parameters (i.e. different wavelengths, fluences, beam types, and beam diameter), and due to the lack of a standardized experimental protocol(s). Before any clinical applications of LLLT for SCI treatment, it is crucial to standardize illumination parameters and efficacy of light delivery. Therefore, in this study we aim to evaluate the light fluence distribution on a 3D voxelated SCI rat model with different illumination parameters (wavelengths: 660, 810, and 980 nm; beam types: Gaussian and Flat; and beam diameters: 0.1, 0.2, and 0.3 cm) for LLLT using Monte Carlo simulation. This study provides an efficient approach to guide researchers in optimizing the illumination parameters for LLLT spinal cord injury in an experimental model and will aid in quantitative and qualitative standardization of LLLT-SCI treatment.

Original languageEnglish
Title of host publicationMechanisms of Photobiomodulation Therapy XIII
EditorsJames D. Carroll, Praveen Arany, Michael R. Hamblin
ISBN (Electronic)9781510614390
DOIs
Publication statusPublished - 1 Jan 2018
EventMechanisms of Photobiomodulation Therapy XIII 2018 - San Francisco, United States
Duration: 27 Jan 201828 Jan 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10477
ISSN (Print)1605-7422

Conference

ConferenceMechanisms of Photobiomodulation Therapy XIII 2018
CountryUnited States
CitySan Francisco
Period27/01/1828/01/18

Keywords

  • illumination parameters
  • Low-level laser therapy
  • Monte Carlo simulation
  • rat model
  • spinal cord injury

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