TY - JOUR
T1 - Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population
AU - Al-Dayel, Fouad
AU - Al-Rasheed, Maha
AU - Ibrahim, Muna
AU - Bu, Rong
AU - Bavi, Prashant
AU - Abubaker, Jehad
AU - Al-Jomah, Naif
AU - Mohamed, Gamal
AU - Moorji, Azadali
AU - Uddin, Shahab
AU - Siraj, Abdul
AU - Al-Kuraya, Khawla
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The last four decades have seen significant increase in the incidence of non-Hodgkin lymphoma (NHL) as a possible result of increasing environmental carcinogens exposure. Based on the increasing evidence for the association between carcinogen-exposure-related cancer risk and xenobiotic gene polymorphisms, we have undertaken a hospital based case-control study on xenobiotic gene polymorphisms in Saudi individuals with a diagnosis of diffuse large B-cell lymphoma (DLBCL). Polymorphisms in five genes (CYP1A1, GSTT1, GSTP1, GSTM1, and NQO1) were characterized in 182 individuals with DLBCL and 513 normal controls using PCR-RFLP method. The CYP1A1*2C (p = 0.011, OR: 6.62, and 95% CI: 1.56 - 28.10), GSTT1 null (p ≤ 0.001, OR: 11.94, 95% CI: 7.88 - 18.12), and GSTP1 TT genotypes (p = 0.017, OR: 3.42, 95% CI 1.26 - 9.38) demonstrated significant association of DLBCL risk. None of the other alleles tested for proved to be significant indicators of DLBCL risk. Our findings suggest that polymorphisms of xenobiotic metabolizing enzyme genes may modify the individual susceptibility to develop DLBCL in Saudi Arabian population.
AB - The last four decades have seen significant increase in the incidence of non-Hodgkin lymphoma (NHL) as a possible result of increasing environmental carcinogens exposure. Based on the increasing evidence for the association between carcinogen-exposure-related cancer risk and xenobiotic gene polymorphisms, we have undertaken a hospital based case-control study on xenobiotic gene polymorphisms in Saudi individuals with a diagnosis of diffuse large B-cell lymphoma (DLBCL). Polymorphisms in five genes (CYP1A1, GSTT1, GSTP1, GSTM1, and NQO1) were characterized in 182 individuals with DLBCL and 513 normal controls using PCR-RFLP method. The CYP1A1*2C (p = 0.011, OR: 6.62, and 95% CI: 1.56 - 28.10), GSTT1 null (p ≤ 0.001, OR: 11.94, 95% CI: 7.88 - 18.12), and GSTP1 TT genotypes (p = 0.017, OR: 3.42, 95% CI 1.26 - 9.38) demonstrated significant association of DLBCL risk. None of the other alleles tested for proved to be significant indicators of DLBCL risk. Our findings suggest that polymorphisms of xenobiotic metabolizing enzyme genes may modify the individual susceptibility to develop DLBCL in Saudi Arabian population.
KW - Diffuse large B-cell lymphoma
KW - Polymorphism
KW - SNP
KW - Xenobiotic genes
UR - http://www.scopus.com/inward/record.url?scp=38549172048&partnerID=8YFLogxK
U2 - 10.1080/10428190701704605
DO - 10.1080/10428190701704605
M3 - Article
C2 - 18203021
AN - SCOPUS:38549172048
VL - 49
SP - 122
EP - 129
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 1
ER -