Role of Caveolin-1 in Diabetes and Its Complications

Research output: Contribution to journalReview article

Abstract

It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus, innovative preventative programs and treatments are a necessity to fight this escalating pandemic disorder. Caveolin-1 (CAV1), an integral membrane protein, is the principal component of caveolae in membranes and is involved in multiple cellular functions such as endocytosis, cholesterol homeostasis, signal transduction, and mechanoprotection. Previous studies demonstrated that CAV1 is critical for insulin receptor-mediated signaling, insulin secretion, and potentially the development of insulin resistance. Here, we summarize the recent progress on the role of CAV1 in diabetes and diabetic complications.
Original languageEnglish
Article number9761539
Pages (from-to)9761539
JournalOxidative Medicine and Cellular Longevity
Volume2020
DOIs
Publication statusPublished - 28 Jan 2020

Fingerprint Dive into the research topics of 'Role of Caveolin-1 in Diabetes and Its Complications'. Together they form a unique fingerprint.

  • Cite this