Seeking sense of antisense switch transcripts

Dania Haddad, Nadine Puget, Nathalie Laviolette-Malirat, Caroline Conte, Ahmed Amine Khamlichi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In B lymphocytes, class switch recombination (CSR) machinery targets highly repetitive sequences, called switch (S) sequences, in the constant domain of the immunoglobulin heavy chain (IgH) locus. Cotranscriptional generation of R loops at S sequences provides the substrate for the mutagenic enzyme AID (Activation-Induced cytidine Deaminase), which initiates the DNA breaks at the transcribed sequences. Both sense and antisense transcripts across the S regions have been reported. Our recent work shows that, unlike its sense counterpart, antisense transcription of S sequences is dispensable for CSR in vivo.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalTranscription
Volume2
Issue number4
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • AID targeting
  • Class switch recombination
  • Sense and antisense transcription

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