Studies on the production of IL-15 in HIV-infected/AIDS patients

Rasheed Ahmad, Sardar Sindhu, Emil Toma, Richard Morisset, Ali Ahmad

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

IL-15 is essential for the development and differentiation of NK cells. It selectively induces proliferation of CD8 + memory T lymphocytes. Despite its importance in both innate and adaptive immune responses, little is known about its production in HIV-infected persons. We report here that IL-15 levels are significantly decreased in the sera of HIV-infected/AIDS patients compared to control sera. We also show that PBMC from the infected patients are compromised in their ability to respond with enhanced production of IL-15 upon exposure to HSV-1. The decreased production of IL-15 occurs despite a comparable increase in IL-15 mRNA in the PBMC of HIV-infected and healthy HIV-seronegative donors when exposed to HSV-1. The HSV-stimulated patients' PBMC exhibited less NK activity compared to similarly treated normal PBMC. These results suggest that a compromised ability of PBMC from HIV-infected individuals to induce IL-15 production in response to a viral stimulus may be a reason of their compromised innate and adaptive immunity.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalJournal of Clinical Immunology
Volume23
Issue number2
DOIs
Publication statusPublished - 1 Mar 2003

Keywords

  • AIDS
  • HIV-1
  • HSV-1
  • IL-15
  • NK activity
  • PBMC

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