The Human Diabetes Proteome Project (HDPP): The 2014 update

D. Schvartz, P. Bergsten, K. H. Baek, A. Barba De La Rosa, J. Cantley, L. Dayon, F. Finamore, P. Fontana, P. Gaudet, Y. A. Goo, R. Moulder, D. Goodlett, J. D. Johnson, A. Konvalinka, H. Mulderm, F. Priego-Capote, S. Sechi, M. Snyder, Ali Tiss, A. WiederkehrI. Xenarios, M. Kussmann, J. C. Sanchez

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Abstract

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalTranslational Proteomics
Volume8-9
DOIs
Publication statusPublished - 1 Dec 2015

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Keywords

  • B/D-HPP
  • Blood
  • Diabetes
  • HDPP
  • HPP
  • Human proteome
  • Islet
  • Network biology

Cite this

Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D., Johnson, J. D., Konvalinka, A., Mulderm, H., Priego-Capote, F., Sechi, S., Snyder, M., Tiss, A., ... Sanchez, J. C. (2015). The Human Diabetes Proteome Project (HDPP): The 2014 update. Translational Proteomics, 8-9, 1-7. https://doi.org/10.1016/j.trprot.2015.03.001