TY - JOUR
T1 - The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis
AU - Alsaeid, K.
AU - Haider, M. Z.
AU - Sharma, Prem
AU - Ayoub, E. M.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - We have determined the prevalence of human leukocyte antigen (HLA)-DR, DQ and DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis (OA-JIA) and healthy controls using the PCR-SSP (sequence specific primers) method. The analysis took into account the presence of antinuclear antibodies and chronic anterior uveitis. DRB1*03 (RR 2.20, P < 0.001), DRB1*08 (RR 5.280, P < 0.026), DQA1*0501 (RR 1.930, P < 0.001), DQB1*0304 (RR 7.920, P < 0.002), DQB1*0501 (RR 3.080, P < 0.007) and DPB1*0101 (RR 8.8, P < 0.001) were the main HLA alleles associated with OA-JIA in Kuwaiti Arabs in this study. DRB1*03 was detected in 71% of children with positive ANA, and in 50% of children with anterior uveitis. DQA1 alleles *0501, *0103 and *0105 (P < 0.001; 0.029 and 0.024 respectively) were found to be associated with OA-JIA. In contrast, DQA1*0301 and DQA1*0302 alleles appear to be protective in Kuwaiti children (RR 0.153, P < 0.001 and RR 0.278, P < 0.016 respectively). The DQB1 alleles *0304 and *0501 were associated with OA-JIA (P < 0.002 and P < 0.007 respectively). In the case of DPB1, only one allele (*0101) was associated with OA-JIA (P < 0.001). Most Kuwaiti Arab patients with OA-JIA who carried a DQ or DP susceptibility allele also had an accompanying DRB1*03 or *8 allele.
AB - We have determined the prevalence of human leukocyte antigen (HLA)-DR, DQ and DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis (OA-JIA) and healthy controls using the PCR-SSP (sequence specific primers) method. The analysis took into account the presence of antinuclear antibodies and chronic anterior uveitis. DRB1*03 (RR 2.20, P < 0.001), DRB1*08 (RR 5.280, P < 0.026), DQA1*0501 (RR 1.930, P < 0.001), DQB1*0304 (RR 7.920, P < 0.002), DQB1*0501 (RR 3.080, P < 0.007) and DPB1*0101 (RR 8.8, P < 0.001) were the main HLA alleles associated with OA-JIA in Kuwaiti Arabs in this study. DRB1*03 was detected in 71% of children with positive ANA, and in 50% of children with anterior uveitis. DQA1 alleles *0501, *0103 and *0105 (P < 0.001; 0.029 and 0.024 respectively) were found to be associated with OA-JIA. In contrast, DQA1*0301 and DQA1*0302 alleles appear to be protective in Kuwaiti children (RR 0.153, P < 0.001 and RR 0.278, P < 0.016 respectively). The DQB1 alleles *0304 and *0501 were associated with OA-JIA (P < 0.002 and P < 0.007 respectively). In the case of DPB1, only one allele (*0101) was associated with OA-JIA (P < 0.001). Most Kuwaiti Arab patients with OA-JIA who carried a DQ or DP susceptibility allele also had an accompanying DRB1*03 or *8 allele.
KW - Antinuclear antibody
KW - HLA
KW - Oligoarthritis
KW - Uveitis
UR - http://www.scopus.com/inward/record.url?scp=29244489552&partnerID=8YFLogxK
U2 - 10.1007/s00296-004-0553-y
DO - 10.1007/s00296-004-0553-y
M3 - Article
C2 - 15703957
AN - SCOPUS:29244489552
VL - 26
SP - 224
EP - 228
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 3
ER -