The role of thymidine kinases in the activation of pyrimidine nucleoside analogues

Ashraf Al Madhoun, Werner Tjarks, Staffan Eriksson

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1 thymidine kinase. Important substrate activity relationships will be discussed.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalMini-Reviews in Medicinal Chemistry
Volume4
Issue number4
DOIs
Publication statusPublished - 1 Jan 2004

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Keywords

  • BNCT
  • Chemotherapy
  • Dm-dNK
  • HSV1-TK
  • Nucleoside analogues
  • TK1
  • TK2

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