Therapeutic targeting of B7-H1 in breast cancer

Amal Hasan, Hazem Ghebeh, Cynthia Lehe, Rasheed Ahmad, Said Dermime

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Introduction: Breast cancer is the most common form of malignancy occurring in women worldwide. B7-H1 is a co-inhibitory molecule expressed by several types of tumors, including breast cancer. The aberrant expression of B7-H1 in breast cancer cells has been determined, its role in recruiting regulatory T cells into the tumor microenvironment has been elucidated and a strong link to B7-H1 induction in highly proliferative breast cancer has been provided. It has also been demonstrated that doxorubicin, a drug commonly used for breast cancer treatment, downregulates the cell surface expression of B7-H1 and upregulates its nuclear expression, which therefore suggests an anti-apoptotic role of B7-H1 in breast cancer. Areas covered: This review illustrates the various factors involved in the induction of B7-H1 and its role in immune evasion and chemoresistance. It also provides potential therapeutic strategies for targeting B7-H1 in breast cancer. Expert opinion: B7-H1 should be considered as a potential therapeutic target for breast cancer. Indeed, there is increasing evidence for the potential efficacy of B7-H1 blockade in the prevention of immune evasion by cancer cells. Additionally, B7-H1 targeting can be used in conjunction with other therapeutic modalities for improved efficacy and reduced toxicity. We expect that B7-H1 blockade in combination with other therapeutics will be a prime therapeutic strategy in the future.

Original languageEnglish
Pages (from-to)1211-1225
Number of pages15
JournalExpert Opinion on Therapeutic Targets
Volume15
Issue number10
DOIs
Publication statusPublished - 1 Oct 2011

Keywords

  • apoptosis
  • B7-H1
  • breast cancer
  • doxorubicin
  • immune evasion
  • immunomodulation
  • immunosuppression
  • immunotherapy
  • programmed death-1
  • silencing RNA
  • therapeutic targeting

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