TY - JOUR
T1 - Uses of microarray platforms in cancer
T2 - a correlative study between genomic copy number changes and their expression at mRNA and protein levels.
AU - Al-Mulla, Fahd
AU - Al-Tamimi, Raba
PY - 2007/1/1
Y1 - 2007/1/1
N2 - With the completion of the Human Genome Project, the microarray technology has evolved into a sophisticated platform by which complex diseases such as cancer, can be studied at the genome, transcriptome, and proteome levels. Here, various microarray platforms, namely comparative genomic hybridization, cDNA, oligonucleotide, and protein-based microarrays are exploited to study genomic copy-number changes in a human cancer cell line and correlate these genomic aberrations with their expression at mRNA and protein levels. The protocols described therein can be assimilated for the study of other human tissues including cancerous ones.
AB - With the completion of the Human Genome Project, the microarray technology has evolved into a sophisticated platform by which complex diseases such as cancer, can be studied at the genome, transcriptome, and proteome levels. Here, various microarray platforms, namely comparative genomic hybridization, cDNA, oligonucleotide, and protein-based microarrays are exploited to study genomic copy-number changes in a human cancer cell line and correlate these genomic aberrations with their expression at mRNA and protein levels. The protocols described therein can be assimilated for the study of other human tissues including cancerous ones.
UR - http://www.scopus.com/inward/record.url?scp=40449128022&partnerID=8YFLogxK
M3 - Article
C2 - 18220226
AN - SCOPUS:40449128022
VL - 382
SP - 77
EP - 95
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -